1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAZD1981Cat. No.: HY-15950CAS No.: 802904-66-1分式: CHClNOS分量: 388.87作靶點: Prostaglandin Receptor作通路: GPCR/G Protein儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 31 mg/mL (79.72 mM)* means so

2、luble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5716 mL 12.8578 mL 25.7155 mL5 mM 0.5143 mL 2.5716 mL 5.1431 mL10 mM 0.2572 mL 1.2858 mL 2.5716 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 AZD1981CRTh2(DP2; GPR44)效選擇性拮抗劑。REFERENCES1. Royer J

3、F, et al. A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils. Eur J Clin Invest. 2008Sep;38(9):663-71.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Luker T, et al. Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZ

4、D1981. Bioorg Med ChemLett. 2011 Nov 1;21(21):6288-92.3. Snell N, et al. Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD. Respir Med.2013 Nov;107(11):1722-30.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-