1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMF63Cat. No.: HY-13283CAS No.: 892549-43-8分式: CHClN分量: 378.81作靶點: PGE synthase作通路: Immunology/Inflammation儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 43 mg/mL (113.51 mM)* means soluble

2、, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.6398 mL 13.1992 mL 26.3985 mL5 mM 0.5280 mL 2.6398 mL 5.2797 mL10 mM 0.2640 mL 1.3199 mL 2.6398 mL請根據(jù)產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 MF63mPGES-1抑制劑，對豬mPGES-1和mPGES-1的IC50分別為0.9 nM和1.3 nM。REF

3、ERENCES1. Xu D et al. MF63 2-(6-chloro-1H-phenanthro9,10-dimidazol-2-yl)-isophthalonitrile, a selective microsomal prostaglandin E synthase-1inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-61/2 Master of Small Molecules 您邊的抑制劑師www

4、.MedChemE2. Cot B et al. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett.2007 Dec 15;17(24):6816-20.3. Baragatti B, Coceani F.,Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin Es

5、ynthase-1 inhibitor, 2-(6-chloro-1H-phenanthro9,10dimidazole- 2-yl)isophthalonitrile.,Neonatology. 2011;100(2):139-46. Epub4. Giroux A, et al. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.,BioorgMed Chem Lett. 2009 Oct 15;19(20):5837-41

6、. Epub 2009 Aug 28.5. Xu D, L,et al. MF63 2-(6-chloro-1H-phenanthro9,10-dimidazol-2-yl)-isophthalonitrile, a selective microsomal prostaglandin Esynthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.,J Pharmacol Exp Ther. 2008 Sep;326(3):75McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400