1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERRx-001Cat. No.: HY-16438CAS No.: 925206-65-1分式: CHBrNO分量: 268.02作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (373.11 mM)* means soluble, but sa

2、turation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.7311 mL 18.6553 mL 37.3107 mL5 mM 0.7462 mL 3.7311 mL 7.4621 mL10 mM 0.3731 mL 1.8655 mL 3.7311 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以

3、根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.33 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.33 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecul

4、es 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (9.33 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 RRx-001種有效的葡萄糖-6-磷酸脫氫酶 (G6PD) 抑制劑。 RRx-001具有強(qiáng)抗瘧效果, 藥物敏感性測(cè)試表明,抑制寄活性IC50 = 0.14 ug/ml。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Mol Cell. 2019 Aug. J Exp Clin Cancer Res. 2019 Feb 20;38(1):90.See more customer validations on HYPERLINK / www

5、.MedChemEREFERENCES1. Yalcin O, et al. From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria. Malar J. 2015 May28;14:218.2. Scicinski J, et al. Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent. DrugMetab Dispos. 2012 Sep;40(9):1810-1816.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0