1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMC-DOXHZN hydrochlorideCat. No.: HY-16261BCAS No.: 480998-12-7Synonyms: Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride分式: CHClNO分量: 787.21作靶點: Topoisomerase; ADC Cytotoxin作通路: Cell Cycle/DNA Damage; Antibody-drug Conjuga

2、te/ADCRelated儲存式: Please store the product under the recommended conditions inthe COA.溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (158.79 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.2703 mL 6.3515 mL 12.7031 mL5 mM 0.2541 mL 1.2703 mL 2.5406 mL10 mM 0.1270 mL 0.6352 mL 1.2703 mL請根據(jù)產(chǎn)品在不同溶

3、劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (2.64 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% S

4、BE-CD in saline)Solubility: 2.08 mg/mL (2.64 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 MC-DOXHZN hydrochlorideDoxorubicin 的蛋結(jié)合前藥，具有酸敏感性 1。戶使本產(chǎn)品發(fā)表的科研獻 Mol Pharm. 2017 Nov 6;14(11):3739-3749. Mol Pharm. 2015 Jul 6;12(7):2217-28. Bioconjug Chem. 2017 Oct

5、 18;28(10):2530-2537. Int J Pharm. 2016 Oct 15;512(1):1-13. China Biotechnology. 2017, 37(4): 68-75.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Sevim Rollas, et al. Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin. The Open Drug DeliveryJournal, 2008, 2, 77-85.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02