1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENaftidrofuryl oxalateCat. No.: HY-B1107CAS No.: 3200-06-4Synonyms: Nafronyl oxalate salt分式: CHNO分量: 473.56作靶點(diǎn): 5-HT Receptor作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1

2、month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 10 mg/mL (21.12 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1117 mL 10.5583 mL 21.1166 mL5 mM 0.4223 mL 2.1117 mL 4.2233 mL10 mM 0.2112 mL 1.0558 mL 2.1117 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Naftidrofury

3、l oxalate (Nafronyl oxalate salt)在外周 和腦管病癥如管擴(kuò)張藥的管理中使的藥物, 增加細(xì)胞氧化能, 且 種 5-HT2 受體拮抗劑。IC50 & Target 5-HT2 receptor體外研究Naftidrofuryl oxalate (Nafronyl oxalate salt) may be effective for relieving the pain of muscle cramps 1.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemENaftidrofuryl oxalate (Nafronyl

4、oxalate salt) is the only vasoactive drug for peripheral arterial disease (PAD)which is likely to be cost-effective 2.Naftidrofuryl oxalate (Nafronyl oxalate salt) is ranked first for both maximum walking distance (MWD) andpain-free walking distance (PFWD) (probability of 0947 and 0987, respectively

5、, of being the best treatment)followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments forclaudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events 3.REFERENCES1. Naftidrofuryl2. Meng Y, et al.

6、Cost-effectiveness of cilostazol, naftidrofuryl oxalate, and pentoxifylline for the treatment of intermittent claudication inpeople with peripheral arterial disease. Angiology. 2014 Mar;65(3):190-197.3. Stevens JW, et al. Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittentclaudication. Br J Surg. 2012 Dec;99(12):1630-1638.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te