1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE6-MethylcoumarinCat. No.: HY-N1406CAS No.: 92-48-8分式: CHO分量: 160.17作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (780.42 mM)* means soluble, but saturation

2、 unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 6.2434 mL 31.2168 mL 62.4337 mL5 mM 1.2487 mL 6.2434 mL 12.4867 mL10 mM 0.6243 mL 3.1217 mL 6.2434 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 6-Methylcoumarin種泛于化妝品的合成料。體外研究6-Methylcoumarin is reported to be almost

3、 nonphototoxic in epidermal tissue and cell culture phototoxicitytest models. HaCaT cells are treated with 6-Methylcoumarin (1-105 nM) and/or UVA (5 J cm-2), and -H2AXis detected by immunofluorescence staining and western blotting 4hours after the treatments. 6-Methylcoumarin clearly produces -H2AX-

4、positive cells under UVA irradiation from a concentration of 100 nM1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1.REFERENCES1. Toyooka T, et al. Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. J Invest Dermatol. 2011Jun;131(6):1313-21.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0