1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEALLO-2Cat. No.: HY-117407CAS No.: 1357350-60-7分式: CHFNO分量: 371.32作靶點: Smo作通路: Stem Cell/Wnt儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)Mass Solvent1 mg 5 mg

2、10 mg Concentration制備儲備液1 mM 2.6931 mL 13.4655 mL 26.9309 mL5 mM 0.5386 mL 2.6931 mL 5.3862 mL10 mM 0.2693 mL 1.3465 mL 2.6931 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)

3、：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (5.60 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (5.60 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 ALLO-2是有效的 Smo耐藥突變體的拮抗劑，在TM3-Gli-Luc細胞中能

4、夠抑制Smo激動劑Hh-Ag1.5誘導的熒光素酶表達，其IC50 值為6 nM。IC50 & Target IC50: Smo 1.REFERENCES1. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr22;18(4):432-7.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-