1、Sequentialdevelopmentofaand diffuselargeb-celllymphoma apatientremotehistoryoffollicularlymphomawithgenotypic evidenceof clonalrelationship:adivergent(bilineal)neoplastictransformationofan indolentcelllymphomainasingleSequentialdevelopmentofaand diffuselargeb-celllymphoma apatientremotehistoryoffoll

2、icularlymphomawithgenotypic evidenceof clonalrelationship:adivergent(bilineal)neoplastictransformationofan indolentcelllymphomainasingleFollicular lymphoma (FL) often transforms to diffuse large B-cell lymphoma duringitsprotractedclinicalcourse.Rarely,a(HS)occurs to or concurrent with FL, although t

3、he biological relationship n these morphologicallyandimmunophenotypicallydistincthesameindividualnot been well characterized. We report a unique case showing the occurrence, HS and then DLBCL in a patient remotehistoryofcase, HS developed 17 years after the diagnosis of FL and was shown to partly th

4、e immunophenotypic features characteristic of FL, while showing the morphologic andimmunophenotypic profiles diagnostic of HS. DLBCL occurred 18.5years after Both HS and DLBCL harbored the IGH/BCL2 hase fluorescence in situ gene, a hallmark of FL, ysis. Immunoglobulin rearrangementstudiesshowedaclon

5、alrearrangementoftheIGHgeneinbothHSDLBCL with licons, suggesting a shared origin of the neoplastic These data support the hypothesis of transdifferentiation or transevolution in matureB-cellneoplasm,and,inaddition,suggestneoplastictransformationofFL inasinglesibilityofadivergent一例連續(xù)進展為組織細胞肉瘤和彌證明來源于同

6、一克?。和卸栊訠 FL HSDLBCL。在本病例中，HS FL17 HS FL 分免疫學表型特征。DLBCL FL 18.5 年。HS DLBCL FL 的特征改變IGH/BCL2 。HS DLBCL 中惰性B Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a with chronic lymphocytic leukemia/small lymphocytic lymphoma treated fludarabine: a dimorphic ion of iatrogenic immunodefic

7、iency-.transformabilityofBcellsbyEpstein-AConcurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a with chronic lymphocytic leukemia/small lymphocytic lymphoma treated fludarabine: a dimorphic ion of iatrogenic immunodeficiency-.transformabilityofBcellsbyEpstein-A small fraction of pati

8、ents with chronic lymphocytic leukemia/small lymphoma develop Epstein-itive B-cell lymphoproliferative toimmune-B-celllymphoproliferativedisordersarethoughttobeinducedbyfludarabine/otheruticregimens.in other immunodeficiency-ted lymphoproliferative disorders, these demonstrateaheterogeneous histolog

9、icaltranges frompolymorphicmonomorphic to classical Hodgkin lymphoma-like s. We report a case concurrentclassicalHodgkinlymphomaandplasmablasticlymphomainapatientchroniclymphocyticleukemia/smalllymphocyticlymphomatreatedwithfludarabine. Both classical Hodgkin lymphoma and plasmablastic lymphoma itiv

10、e -encoded RNA, whereas classical Hodgkin lymphoma was itiveforEpstein-latentmembrane protein1,suggestingadifferentlatency.Immunoglobulingenerearrangementstudiesdemonstrateddistinctclonesthe plasmablastic lymphoma and chronic lymphocytic leukemia/small lymphoma. These findings suggest biclonal secon

11、dary lymphomas ted iatrogenic immunodeficiency. Epstein-B-cell lymphoproliferative in the setting of chronic lymphocytic leukemia/small lymphocytic lymphoma, particular those arising after chemotherapy, should be separated from true transformation, and be categorized as (iatrogenic) immunodeficiency-lymphoproliferative金淋巴瘤和漿母細胞淋巴瘤的CLL/SLLB CLL