1、FinalTestPaperofHumanParasitologyforlongtermmedicalstudentsZhongshanSchoolofMedicine,SunYat-senUniversity：TestPaperType ATestTime： Testmethod：Closed-booktestTestdate：January9,2012AnswersPartOneChoosethecorrectanswer（1scoreforeach,andthetotalscoreis40）TypeA:ChoosethebestanswerfromA,B,C,DandE.1. Which

2、tissueororganisthecommonparasiticsiteofhydatid?A.thoraciccavityB.lungsC.brainD.liverE.abdominalcavity2. Whichstageof trichomonas vaginalisnfectivestage?A.trophozoiteB.cystC.maturecystD.oocystE.encystedlarvae3.WhichstageofplasmodiumisthestagewithA.exo-erythrocyticstageB.erythrocyticstageC.gametocyteD

3、.sporozoiteE.oocystpathogenicity?4.Whichtypeofimmune-responseisassociatedwithprotozoalinfection?A.sterilizingimmunityB.Non-acquiredimmunity C.premonitionD.concomitantimmunityE.premonitionandconcomitantimmunity5.Formostparasiticdiseases,whatplaystheroleofsourcesofinfection?A.reservoirhostB.patientand

4、carrierC.paratenichostortransporthostD.intermediatehostE.infectedpersonandinfectedanimal6.Ifcontactingsoilwithbarefootsintheteaorvegetablegarden,whichparasitedoyougetinfection?A.ClonorchissinensisB.hookwormC.filariaD.Fasciolahepatica E.Trichnellaspiralis7.Whichparasiteisopportunisticparasite?A. Enta

5、moebahistolytica B. Plasmodiumfalciparum C.ToxoplasmagondiiD. Leishmaniadonovani E.Trichomonasvaginalis8.Whichdiseasesarefood-borneparasitosis?A.schistosomiasis,clonorchiasis,ascariasis,angiostrogyliasis,taeniasis,toxoplasmosisB.ascariasis,hydatosis,trichinellosis,angiostrogyliasis,taeniasis,toxplas

6、mosisC.clonorchiasis,trichinellosis,ascariasis,angiostrogyliasis,taeniasis,toxplasmosisD.trichinellosis,paragonimiasis,chonorchiasis,angiostrogyliasis,taeniasis,toxplasmosisE.pulmonaryparagonimiasis,trichinellosis,angiostrogyliasis,hydatosis,taeniasis,toxplasmosis9.WhichparasitecancauseKeratitis?A.

7、Entamoebacoli B. Entamoebahistolytica C. EntamoebadisparD. Entamoebagingivalia E.Acanthamoebaspecies10. Whichmethodcanbeusedtodiagnosekala-azardiseasesorleishmaniasis?A.bloodsmearB.clinicalmanifestationC.stoolexamination第1頁(yè)共 10頁(yè)D.bonemarrowsmearE.cellculture11.Whichmosquitocanbecontrolbyreducingsmal

8、lormini-freshwater-breedinggrounds?A. Aedesalbopictus B.Anophelesdirus C.CulexpipienspallensD. Anophelessinensis E. Culexpipiensquinquefasciatus12.WhichclinicalmanifestationwascausedbyGiardialamblia infection?diarrhoeaA.bloodypurulentstool B.acuteorchronicC.FeverD.anaemiaE.jaundice13.Whichstageof En

9、tamoebahistolytica isinfectivestage?A.cystwithtwo nucleus B.trophozoiteC.oocystD.amastigotesE.cystwithfournucleus14.Whichparasitecanbeexaminedbyastripofcellophanetape?A.eggsofschistosomesB.hookwormeggsC.pinwormeggsD.eggsof Ascarialumbricoides E.whipwormeggs15.Whichstageofplasmodiumistheinfectivestag

10、e?A.oocystB.sporozoitesC.gametocyteD.ringformE.zygote16. Whydoes Taeniasoliumcausemoreseriousharmthan Taeniasaginata ?A. TaeniasaginatawithlesstoxinB. Taeniasolium withsmallhooksandrostellumC.morewormsof Taeniasolium parasitizeinhumanbeingD.cysticerciof TaeniasoliumcanparasitizeinhumanbeingE.traumao

11、foncosphere17.Whichpathogenesisispathogeniceffectcausedbyschistosomaeggs?majorA.bloodvesselswereblockedbyeggsB.liverinjurycausedbyeggstoxinC.liverandintestinaltissueswerecompressedbyeggsD.hypersensitivityandegg-granulomacausedbythemetabolicandexceretoryproductsofeggsE.inflammationcausebyeggantigens1

12、8.Whichepidemiologicalfeaturesarecorrelatedtotrichinellosis?A.endemicityandgroupeventsB.endemicity,groupeventsandfood-borneinfectionC.endemicity,andfood-borneinfectionD.groupeventsandfood-borneinfectionE.zoonoses19.WhichfreshwatersnailistheintermediatehostofAngiostrongylus cantonensis?東風(fēng)螺)A. Alocinm

13、alongicornis (長(zhǎng)角涵螺)B.GiantAfricansnail(C.planorbid( 扁卷螺)D.melania(川卷螺)E. Oncomelaniahupensis (湖北釘螺)20.Whichparasitecanbere-infectedbycontactinganusregionsofpatientandbyhand-to-mouthtransmission?A.hydatidosisB.AscariasisC.hookwormdiseaseD.TrichuriasisE.Enterobiasis21 Whichvectorcantransmitforestencep

14、halitis?A.humanfleaB.liceC.bedbugsD.tickE.mite22.Whichdrugcanbeusedtotreatnematodeinfection?第2頁(yè)共 10頁(yè)A.AlbendazoleB.SpiramycinC.penicillinD.chloroquineE.Sulfamethoxazolum-Trimethoprimum(SMZ-TMP)TypeB:ChoosethecorrectanswerfromA,B,C,DandEtothesquarebracketofeachitem.Question2326Whatdamageswerecausedby

15、thefollowingparasites?A. EntamoebahistolyticaB. EchinococcusgranulosusC. PlasmodiumfalciparumD. AscarislumbricoidesE. Schistosomajaponicum（）23.tocauseintestinalobstruction（）24.tocauseseriousanemia25.tocauselivercirrhosis26.tocause liverabscess（）（）Question2730Whichparasitecanbeinfectedbyeatingthefoll

16、owingrawfood?A.freshwaterfishB.beefC.frogD.waterplantsE.crabs27. Spirometramansoni（）28. Paragonimuswestermani （）29. Fasciolopsisbuski （）（）30. TaeniasaginataTypeX:ChoosethecorrectanswerfromA,B,C,DandE,andthecorrectanswermaybenotjustone.31.Whichparasite(s)cancausesplenomegaly?第3頁(yè)共 10頁(yè)A.plasmodiumB.Ent

17、amoebahistolytica C. schistosomajaponicumD. StrongyloidessppE. Leishmaniadonovani32.Whichstageofprotozoacaninfecthumanbeing?A.trophozoiteof ToxoplasmagondiiB.trophozoiteofEntamoebahistolyticaC.trophozoiteof Trichomonasvaginalis D.trophozoiteof GiardialambliaE.oocystofCryspordium33.Whichmiteorinsectc

18、anparasitizeinhumanbodyforlongertime?A.scabmiteB.mosquitoC.cockroachD.liceE.trombiculidmite34.Whichdisease(s)canbetransmittedbymedicalarthropods?A.filariasisB.pulmonaryparagonimiasisC.malariaD.Kala-azardiseaseE.trichinellosis35.Whichdamagestohumanbeingarecausedbyparasites?A.lossnutritionB.Directdama

19、gesuchastraumaC.inapparentinfectionD.toxinandinflammationE.polyparasitism36.Whichparasite(s)cancauseviscerallarvamigrans?A. Gnathostamaspinigerum B. Pagumogonimusskrjabini C.AnisakisD. SpirometramansoniE. Angiostrongyluscantonensis37.Whichparasite(s)canparasitizeinbrain?A. Angiostrongyluscantonensis

20、B. SpirometramansoniC. TaeniasoliumD. Fasciolopsisbuski E. Fasciolahepatica38.WhichvectorscantransmitmalariainChina?A. Anophelessinensis B, Anophelesanthrophagus C. AnophelesminimusD. Culexpipienspallens E. Anophelesdirus39.Whichdirectdamagesarecausedbymedicalarthropods?A.toxicosisB.harassmentandsuc

21、kingbloodC.suckingbloodandtransmittingdiseasesD.invadingtissueE.allergy40.Whichstageofparasitecanbedetectedbystoolexamination?A.eggsof AscarislumbricoidesB.eggsof Schistosomajaponicum第4頁(yè)共 10頁(yè)C.hookwormrhabditoidlarvaD.whipwormeggsE.eggsof Fasciolopsis buskiPartTwoIteminterpretation（3scoresforeach,an

22、dthetotalscoreis12）1.immunoevasionofparasiteParasitessurviveandproliferateinimmunologicallycompetenthostbyintracellularlocation,antigenicshedding,antigenicvariation,antigenicmimicry,andmodificationofhostimmuneresponses.2.paratenichostortransporthostThelarvaofsomeparasitescaninvadeanon-normalhost,but

23、cannotgrow,andonlylivesinthelarvastage.Ifthelarvaentersanormaldefinitivehost,itcancontinuetogrowintoanadultworm.Thenon-normalhostiscalledparatenichostortransporthost.IpletemetamorphosisFromeclosinoflarvaornymphtoadult,therearewidedifferencesinthemorphology,physiologicalfunctionandlivinghabits.Thepro

24、cessofthechangeiscalledmetamorphosis.Thecompletemetamorphosisincludesegg,larva,pupaandadult.4.relapseofmalariaTherearenomalariaparasitesinredbloodcellsafterantimalarialdrugtreatment.Howevermalariaisbackintothediseaseweeks,monthsorevenyearsaftertheapparentcurewithoutnewinfection.Itcausedbyhypanzoites

25、developintoschizontsinlivercells.OnlyP.vivaxandP.ovaleofhumanscauserelapse.第5頁(yè)共 10頁(yè)P(yáng)artThreeAnswerthequestionbriefly（5scoresforeach,andthetotalscoreis10）1. Inlaboratory,howtomakemouseinfectplasmodiumparasite?Andhowtoprovethemousehasbeeninfected？Answer:Obtain2dropsofbloodfromP.bergheiinfectedmousetai

26、l,dilutedin2-mlsalinesolution;inject0.1-mldilutedbloodtoamouseabdominalcavity.Afteroneweek,collectbloodfromparasiteinfectedmousetailtomakethinandthickbloodfilms.FixthefilmwithmethylalcoholandstainwithGiemsassolution,andthenexamtheslidetofindmalariaparasitesunderimmersionoilmicroscope.2.Whichdiseases

27、canbetransmittedbymosquito?Pleasedescribethetransmission.mechanismofdisease-Answer:Thefollowingdiseasescanbetransmittedbymosquito:Malaria,Filariasis,JapaneseBencephalitis,Denguefever(oryellowfever).Malaria:developmentandproliferationFilariasis:developmentJapaneseBencephalitis:proliferation(ortransmi

28、ssionbyegg)Denguefever:proliferation(ortransmissionbyegg)PartFourAnswerthequestions.(Thetotalscoreis38)1.SchistosomiasisisstillanimportantpublichealthprobleminChina,pleasetellmehowtocontrolthedisease.(10scores)第6頁(yè)共 10頁(yè)Answer:Therearedifferentmethodsusedindifferentendemicareas.A. Eliminationoftheinfe

29、ctiveresources:a. Selectivechemotherapyforhuman,chemotherapyforlivestoke;b. Medicine,Praziquantel;B. Cutoffthetransmisionroute:a. Snailcontrol;intermieatehost Oncomelaniahupensis ;b. Fecesmanagement:includinghumanandlivestocksstool;killtheeggs;c. Safewatersupply:C. Protectingsusseptibelindividual:a.

30、 Healtheducation;toknowthelifecycleofSchistosomajaponicum .d. Individualprevention:takingartemisinin;avoidingcontactwithinfectedwater.2.Ifyoudrankun-boilingwater,whichparasiteswillyouinfect?Whichstagesofthoseparasitesareinfectivestage?Pleasedescribethepathogenesisandharmsonhumanbyusingtwoparasitesas

31、examples.(13scores)Answer:Parasitesfromdrinkingun-boiledwater:1) Entamoebahistolytica ,four-nucleicyst;2) Giardialamblia,four-nucleicyst;3) Cryptosporidium,oocyst;4) Trichuristrichiura,egg; Enterobiusvermicularis,egg,etc.Examples:1) Pathogenesisof Entamoebahistolytica :A. Theamoebaesecrateproteolyti

32、cenzymestohydrolysehost.B. Slenderductlikeulcerinthelumenofintestine;C. Intestinalamebiasisandextraintestinalamebiasis.2) Pathogenesisof Giardialamblia:A. Mechanicalblochageoftheintestinalmucosa,competitionfornutrients,inflammtionoftheintestinalmucosa,etc.B. Shorteningofmicrovilli;C. Diarrhea,abdomi

33、nalpain,nauseaandvomitting;D. Commonlyinfectedimmuno-suppressedpersons.3.Clinicalcaseanalysis(15scores)Apreviouslyhealthy26-yr-oldmalewasreferredtoourhospitalbecauseofrecentlyrecognizedjaundice.Hecomplainedofanorexia,fatigue,andweightlossof8kgoverthepreviouseightmonths.HelivesinthesuburbsofGuangzhou.Themedicalhistorywasunremarkableexceptforingestionofrawfreshwaterfish.Thepatienthadabloodpressureof124/81mm