1、Biochemistry I Self-IntroductionZhen LI 李 珍BS (Wuhan University)PhD (Carnegie-Mellon University, USA)Post-doctoral fellow (University of Michigan & Stanford University, USA)Research associate (Hong Kong University of Science and Technology, Hong Kong)Joined Tsinghua University in 2004Taught Biochemi

2、stry II since Spring, 2004Taught Biochemistry I since Spring, 2012Self-IntroductionContact information:School of Life SciencesTsinghua UniversityTel: 6277-0581 Office: Room 245, New Biology BuildingLab: Room 244 & 253, New Biology Building E-mail: Self-IntroductionResearch interest:Adiponectin-targe

3、ted drug developmentMolecular mechanism of adiponectin multimerization and secretion Screen for new drugs to treat type 2 diabetes(糖尿病)Biochemistry is the chemistry of lifeDescribe in molecular terms the structures, mechanisms, and chemical processes shared by all organismsProvides organizing princi

4、ples that underlie life in all its diverse formsProvides important insights and practical applications in medicine, agriculture, nutrition, and industryThree parts of BiochemistryThe structural chemistry of the components of living organisms and the relationship between chemical structure and biolog

5、ical function - Part IMetabolism - the chemical reactions that occur in living organisms - Part II The chemistry of molecules and processes that store and transmit biological information - Part IIIBiochemistry is an multidisciplinary scienceOrganic chemistry: describes the structure and properties o

6、f biomoleculesMicrobiology: shows that single-celled organisms and viruses are ideally suited for studying many metabolic pathways and regulatory mechanisms Cell biology: describes biochemical division of labor and life processes within a cellGenetics: describes the mechanisms that give a cell or or

7、ganism its biochemical identityBiochemistry is an multidisciplinary scienceBiophysics: applies the techniques of physics to study the structure of biomoleculesPhysiology: investigates life processes at the level of tissue or organismNutrition: illuminates metabolism by describing the dietary require

8、ments for health maintenanceMedical research: seeks to understand human diseases in molecular termsCourse IntroductionTextbook:Lehninger Principles of Biochemistry By D. L. Nelson and M. M. Cox, Sixth EditionCourse Introduction TextbookAlbert Lehninger Citric acid cycle occurs in mitochondria Mechan

9、ism of oxidative phosphorylation Mitochondrial structure and function Bioenergetics Author of classic textbooks: Biochemistry (1970-1983) The Mitochondrion (1964) Bioenergetics (1965-1974)Course Introduction Biochemistry I (this semester) Part I: Structure and Catalysis Chapter 1 - Chapter 6 (Week 1

10、-8) By Zhen Li Chapter 7 - Chapter 12 (Week 9-16) By Prof. Dong Liu Prof. Geng Wang Course Introduction Biochemistry II (next semester) Part II: Bioenergetics and Metabolism Chapter 13 - Chapter 23 Part III: Information Pathways Chapter 24 - Chapter 27 All by Zhen Li Course IntroductionReference tex

11、tbooks:* Biochemistry, Fifth Edition (By Berg, Tymoczko and Stryer)* The absolute, ultimate guide to Lehninger Principles of Biochemistry, Fifth Edition (By Marcy Osgood and Karen Ocorr)* Lehninger 生物化學(xué)原理, 第三版, 中文版 (周海夢(mèng),昌增益等譯)Course IntroductionReference textbooks:Course CalendarCourse IntroductionT

12、A: Yudian Zhang 張雨點(diǎn) Lab: Room 253, New Biology Building Tel: 62773630 E-mail: Course Introduction Office Hour: 3 - 5 pm, Friday You are e to come to my office to ask questions about the course! (If you have classes during regular Office Hour, you can send your questions to me via E-mail or make an a

13、ppointment with me by E-mail)Grade for the courseQuiz: total 2, in class accounts for 20% of the final grade (50 points)Final exam: at the end of the semester accounts for 80% of the final grade (50 points)Course IntroductionFirst all-English courseLots of news words and new conceptsExposed to a lar

14、ge amount of information within a relatively short period of timeImpossible to talk about everything in the textbook Rely on you to self-study those not discussed in the lecturesRules of the ClassroomTurn off your mobile phone Keep quiet Raise your hand if you have questionsBe honest in the quiz and

15、 the final examUseful linksWebsite for the course: Website for the textbook: 清華大學(xué)網(wǎng)絡(luò)學(xué)堂: Some useful tipsDont worry too much!Preview (預(yù)習(xí)) before each lectureTake good notes in classReview (復(fù)習(xí)) and do homework after lecturesSpend at least 3 hours every week in this course Ask for help if you have diffi

16、culties or problems in your studyHave enough sleep the night before the lectureSome useful tipsPay attention to the Worked examples, Key Convention, Key Terms (Keywords) and Summary in the textbook and ppt filesMake use of all kinds of learning resourcesTry to use as much English as possible in your reading, writing and thinking Understanding is more important th