乳腺癌五年或更長期的輔助內(nèi)分泌治療：

一項已發(fā)表的隨機試驗的meta分析Fiveormoreyearsofadjuvantendocrinetherapyinbreastcancer:ameta-analysisofpublishedrandomisedtrials——FaustoPetrelli——BreastCancerResTreat2013-6-281乳腺癌五年或更長期的輔助內(nèi)分泌治療：

一項已發(fā)表的隨機試驗的一、背景介紹在早期乳腺癌患者中（BC）2五年他莫西芬（TAM）輔助治療死亡風險復發(fā)風險30%40%在各項隨機試驗中，輔助TAM治療推薦應用：5年延滯效應：這種風險降低可以一直延續(xù)到開始使用內(nèi)分泌治療后的15年，在10年后，死亡風險可降低1/3.一、背景介紹在早期乳腺癌患者中（BC）2五年他莫西芬（TAM一、背景介紹3ALAST12000BC5年VS10年TAM治療中位隨訪13.6年：減少總生存及晚期BC發(fā)生子宮內(nèi)膜癌發(fā)生風險(3.1vs.1.6%),死亡風險增加0.2%。ATTOM10年TAM，減少BC復發(fā)風險(P=0.003),BC相關死亡風險(P=0.05)，整體死亡風險(P=0.1),第九年后的獲益更大。MA175年TAM來曲唑/安慰劑，64個月的中位隨訪中，顯著降低復發(fā)風險，但OS相近。考慮了揭盲后，安慰劑組中66%應用了來曲唑，提示來曲唑顯著提高了DFS和OS。一、背景介紹3ALAST12000BC5年VS二、研究方法1.數(shù)據(jù)來源4電子搜索CochraneControlledTrialsRegisterEMBASEISIWebofSciencePubMed參考文獻/會議記錄檢索策略：(breastcancerORbreastcarcinoma)and(tamoxifenORletrozoleORexemestaneORanastrozole)and(extendedORdurationORlongerORcontinuedOR‘5years’OR‘10years’ORprolongedORcontinuing)and(randomisedORrandomised)二、研究方法1.數(shù)據(jù)來源4電子搜索CochraneEMBAS二、研究方法2.研究選擇/數(shù)據(jù)提取5入選標準提取數(shù)據(jù)早期乳腺癌患者RCT:比較5年及更久內(nèi)分泌治療開始——2013-6-11研究由兩名研究人員分別選擇，出現(xiàn)分歧時有第三名研究人員評議。英文發(fā)表基本信息：雜志名、發(fā)表年份、作者名人口統(tǒng)計學：中位年齡、淋巴結(jié)水平、月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平研究信息：樣本量、研究設計、研究終點治療方案結(jié)果

（率或事件數(shù)）：OS,無復發(fā)生存(RFS),乳腺癌相關生存(BCSS),非癌癥相關死亡,局部或遠處的RFS(LR-RFS/D-RFS)人類研究二、研究方法2.研究選擇/數(shù)據(jù)提取5入選標準提取數(shù)據(jù)早期乳腺二、研究方法6主要終點：OS(隨機至各種原因引起的死亡)，BCSS(隨機至復發(fā)后乳腺癌相關死亡)，RFS(隨機至除對側(cè)乳腺外的復發(fā))次要終點：非腫瘤相關死亡,LR-RFS(BC相關的局灶或區(qū)域復發(fā)時間)andD-RFS(BC相關的遠處復發(fā))數(shù)據(jù)匯總和統(tǒng)計學分析：統(tǒng)計比值比（OR）和95％CI。異質(zhì)性?。汗潭ㄐＰ?Mantel–Haenszel法；異質(zhì)性大：DerSimonian–Laird法（隨機效應模型）。根據(jù)樣本量計算權重。X2及I2檢驗用于不同研究OR異質(zhì)性的檢測。根據(jù)方案（T與芳香酶抑制劑），ER狀態(tài)，LN（N與N-），絕經(jīng)狀態(tài)，對于OS，BCSS和RFS進行了敏感性分析。雙尾P值＜0.05被認為有統(tǒng)計學意義。偏倚：Begg’sandEgger’s檢測及漏斗圖的是否對稱性。分析軟件：ReviewManager5.1(RevMan5.1);(哥本哈根：北歐Cochrane中心，Cochrane協(xié)作網(wǎng)，2008年)和綜合Meta分析軟件（版本2.2.064，2011年7月27日）。二、研究方法6主要終點：OS(隨機至各種原因引起的死亡)三、結(jié)果71、這8個試驗都是Ⅲ期臨床試驗2、除了ABCSG6a外，其余都是經(jīng)5年TAM后隨機3、ECOG和Scottish研究中，觀察至死亡或復發(fā)4、MA17和NSABPB-33試驗中，分別有66%和33%對照組患者在揭盲后接受了實驗組的藥物治療N=291385年TAM：14540繼續(xù)TAM：21554芳香化酶抑制劑：7584三、結(jié)果71、這8個試驗都是Ⅲ期臨床試驗N=291385年T三、結(jié)果8三、結(jié)果8三、結(jié)果9主要終點：1.OS三、結(jié)果9主要終點：1.OS三、結(jié)果10主要終點：2.BCSSBCSS在TAM組的結(jié)果更加明顯三、結(jié)果10主要終點：2.BCSSBCSS在TAM組的結(jié)果更三、結(jié)果11主要終點：3.RFS亞組分析N+OR:0.76，P<0.0001絕經(jīng)后婦女OR:0.8，P<0.0001ER+三、結(jié)果11主要終點：3.RFS亞組分析N+OR:0.76，三、結(jié)果12次要終點：非癌癥相關死亡、LR-DFS、D-DFS非癌癥相關死亡兩組中相似局部復發(fā)風險36%，P=0.02遠處復發(fā)風險13%，P=0.02三、結(jié)果12次要終點：非癌癥相關死亡、LR-DFS、D-DF三、結(jié)果13發(fā)表偏倚Begg’stestP=0.25,Egger’stestP=0.24對OS的OR無影響三、結(jié)果13發(fā)表偏倚Begg’stestP=0.25,四、討論1、14四、討論1、14ClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.AddyourtextAddyourtextAddyourtextAddyourtextAddyourtextAddyourtext15ClicktoedittitlestyleThemeContentsClicktoaddtitleinhereClicktoaddtitleinhereClicktoaddtitleinhereClicktoaddtitleinhere4123ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.16ContentsClicktoaddtitleinHotTip

HowdoIincorporatemylogotoaslidethatwillapplytoalltheotherslides?

Onthe[View]menu,pointto[Master],andthenclick[SlideMaster]or[NotesMaster].Changeimagestotheoneyoulike,thenitwillapplytoalltheotherslides.[Imageinformationinproduct]Image:Notetocustomers:ThisimagehasbeenlicensedtobeusedwithinthisPowerPointtemplateonly.Youmaynotextracttheimageforanyotheruse.17HotTipHowdoIincorporatemClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.AddyourtextAddyourtextAddyourtextAddyourtextAddyourtextAddyourtext18ClicktoedittitlestyleThemeYourTextYourTextYourTextYourTextClicktoedittitlestyleYourTextYourTextYourTextYourText2005200620072008ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.19YourTextYourTextYourTextYouClicktoedittitlestyleDescriptionofthecontentsTextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.20ClicktoedittitlestyleDescClicktoedittitlestyleContents01Contents02Contents03Contents04Contents05Contents060%20%40%60%80%100%18.5%17.5%8.7%23.6%63.6%84.3%ThemeGallery

isaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.21ClicktoedittitlestyleConteClicktoedittitlestyleTextinhereTextinhereTextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ClicktoaddText22ClicktoedittitlestyleTextClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.Titleinhere2.Descriptionofthecompany’ssubcontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.1.Descriptionofthecompany’ssubcontents23ClicktoedittitlestyleThemeClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleinhereTitleinhereTitleinhereTitleinhereABCD24ClicktoedittitlestyleTheme一、背景介紹DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsContentTitleContentTitleContentTitle25ATLAS一、背景介紹DescriptionofthecontClicktoedittitlestyleDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleinhereTitleinhereTitleinhere26ClicktoedittitlestyleDescrClicktoedittitlestyleTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereContentsContentsContentsContentsContentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.27ClicktoedittitlestyleTextClicktoedittitlestyleDescribeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Descriptionoftheproducts28ClicktoedittitlestyleDescrPleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Vision01Vision03Vision02Vision04CompanyLOGOClicktoedittitlestyle29PleasewritedownofPleasewrClicktoedittitlestyleTitleinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsTitleinhereTitleinhereTitleinhere30ClicktoedittitlestyleTitleService01Service02Service03LOGOThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.Clicktoedittitlestyle31Service01Service02Service03ClicktoedittitlestyleTitleinhereAddTitleAddTitleAddTitleAddTitleDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsTextinhereTextinhereTextinhereTextinhereDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontents32ClicktoedittitlestyleTitleClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleTextinhereTextinhereTextinhereTextinhere33ClicktoedittitlestyleThemeClicktoedittitlestyleDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.34ClicktoedittitlestyleDescClicktoedittitlestyleGrowthStartJump200820072006200520042003200220012000Descriptionofthecontents

Descriptionofthecontents

DescriptionofthecontentsDescriptionofthecontents

Descriptionofthecontents

DescriptionofthecontentsDescriptionofthecontents

Descriptionofthecontents

Descriptionofthecontents35ClicktoedittitlestyleGrowtDescriptionofthecontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecompany’stechnologyDescriptionofthecompany’scontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecompany’stechnologyDescriptionofthecompany’scontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecompany’stechnologyDescriptionofthecompany’scontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecompany’stechnologyDescriptionofthecompany’scontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsClicktoedittitlestyle36DescriptionofthecontentsDesClicktoedittitlestyleAddYourTextAddYourTextAddYourTextAddYourTextAddYourTextTextTextTextTextTextThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.37ClicktoedittitlestyleAddYClicktoedittitlestyleTextinhereTitleinhereTextinhereTextinhere2005200620072008DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.38ClicktoedittitlestyleTextClicktoedittitlestyle2005200620072007statisticstitle2007statisticstitle(unit:%)(unit:%)*2007Statisticsagencystatistics*2007Statisticsagencystatistics50%20052006200790%15%96%35%70%Contentsoftheproduct,andpleasefillitout.ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.39Clicktoedittitlestyle20052ClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.80%50%30%20%TitleinhereTitleinhereTitleinhereTitleinhereABCD40ClicktoedittitlestyleThemeDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsM1M2M4M3Clicktoedittitlestyle41DescriptionofthecontentsTheClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontents42ClicktoedittitlestyleThemeThankYou!43ThankYou!乳腺癌五年或更長期的輔助內(nèi)分泌治療：

一項已發(fā)表的隨機試驗的meta分析Fiveormoreyearsofadjuvantendocrinetherapyinbreastcancer:ameta-analysisofpublishedrandomisedtrials——FaustoPetrelli——BreastCancerResTreat2013-6-2844乳腺癌五年或更長期的輔助內(nèi)分泌治療：

一項已發(fā)表的隨機試驗的一、背景介紹在早期乳腺癌患者中（BC）45五年他莫西芬（TAM）輔助治療死亡風險復發(fā)風險30%40%在各項隨機試驗中，輔助TAM治療推薦應用：5年延滯效應：這種風險降低可以一直延續(xù)到開始使用內(nèi)分泌治療后的15年，在10年后，死亡風險可降低1/3.一、背景介紹在早期乳腺癌患者中（BC）2五年他莫西芬（TAM一、背景介紹46ALAST12000BC5年VS10年TAM治療中位隨訪13.6年：減少總生存及晚期BC發(fā)生子宮內(nèi)膜癌發(fā)生風險(3.1vs.1.6%),死亡風險增加0.2%。ATTOM10年TAM，減少BC復發(fā)風險(P=0.003),BC相關死亡風險(P=0.05)，整體死亡風險(P=0.1),第九年后的獲益更大。MA175年TAM來曲唑/安慰劑，64個月的中位隨訪中，顯著降低復發(fā)風險，但OS相近?？紤]了揭盲后，安慰劑組中66%應用了來曲唑，提示來曲唑顯著提高了DFS和OS。一、背景介紹3ALAST12000BC5年VS二、研究方法1.數(shù)據(jù)來源47電子搜索CochraneControlledTrialsRegisterEMBASEISIWebofSciencePubMed參考文獻/會議記錄檢索策略：(breastcancerORbreastcarcinoma)and(tamoxifenORletrozoleORexemestaneORanastrozole)and(extendedORdurationORlongerORcontinuedOR‘5years’OR‘10years’ORprolongedORcontinuing)and(randomisedORrandomised)二、研究方法1.數(shù)據(jù)來源4電子搜索CochraneEMBAS二、研究方法2.研究選擇/數(shù)據(jù)提取48入選標準提取數(shù)據(jù)早期乳腺癌患者RCT:比較5年及更久內(nèi)分泌治療開始——2013-6-11研究由兩名研究人員分別選擇，出現(xiàn)分歧時有第三名研究人員評議。英文發(fā)表基本信息：雜志名、發(fā)表年份、作者名人口統(tǒng)計學：中位年齡、淋巴結(jié)水平、月經(jīng)狀態(tài)、原發(fā)腫瘤的激素水平研究信息：樣本量、研究設計、研究終點治療方案結(jié)果

（率或事件數(shù)）：OS,無復發(fā)生存(RFS),乳腺癌相關生存(BCSS),非癌癥相關死亡,局部或遠處的RFS(LR-RFS/D-RFS)人類研究二、研究方法2.研究選擇/數(shù)據(jù)提取5入選標準提取數(shù)據(jù)早期乳腺二、研究方法49主要終點：OS(隨機至各種原因引起的死亡)，BCSS(隨機至復發(fā)后乳腺癌相關死亡)，RFS(隨機至除對側(cè)乳腺外的復發(fā))次要終點：非腫瘤相關死亡,LR-RFS(BC相關的局灶或區(qū)域復發(fā)時間)andD-RFS(BC相關的遠處復發(fā))數(shù)據(jù)匯總和統(tǒng)計學分析：統(tǒng)計比值比（OR）和95％CI。異質(zhì)性小：固定效應模型/Mantel–Haenszel法；異質(zhì)性大：DerSimonian–Laird法（隨機效應模型）。根據(jù)樣本量計算權重。X2及I2檢驗用于不同研究OR異質(zhì)性的檢測。根據(jù)方案（T與芳香酶抑制劑），ER狀態(tài)，LN（N與N-），絕經(jīng)狀態(tài)，對于OS，BCSS和RFS進行了敏感性分析。雙尾P值＜0.05被認為有統(tǒng)計學意義。偏倚：Begg’sandEgger’s檢測及漏斗圖的是否對稱性。分析軟件：ReviewManager5.1(RevMan5.1);(哥本哈根：北歐Cochrane中心，Cochrane協(xié)作網(wǎng)，2008年)和綜合Meta分析軟件（版本2.2.064，2011年7月27日）。二、研究方法6主要終點：OS(隨機至各種原因引起的死亡)三、結(jié)果501、這8個試驗都是Ⅲ期臨床試驗2、除了ABCSG6a外，其余都是經(jīng)5年TAM后隨機3、ECOG和Scottish研究中，觀察至死亡或復發(fā)4、MA17和NSABPB-33試驗中，分別有66%和33%對照組患者在揭盲后接受了實驗組的藥物治療N=291385年TAM：14540繼續(xù)TAM：21554芳香化酶抑制劑：7584三、結(jié)果71、這8個試驗都是Ⅲ期臨床試驗N=291385年T三、結(jié)果51三、結(jié)果8三、結(jié)果52主要終點：1.OS三、結(jié)果9主要終點：1.OS三、結(jié)果53主要終點：2.BCSSBCSS在TAM組的結(jié)果更加明顯三、結(jié)果10主要終點：2.BCSSBCSS在TAM組的結(jié)果更三、結(jié)果54主要終點：3.RFS亞組分析N+OR:0.76，P<0.0001絕經(jīng)后婦女OR:0.8，P<0.0001ER+三、結(jié)果11主要終點：3.RFS亞組分析N+OR:0.76，三、結(jié)果55次要終點：非癌癥相關死亡、LR-DFS、D-DFS非癌癥相關死亡兩組中相似局部復發(fā)風險36%，P=0.02遠處復發(fā)風險13%，P=0.02三、結(jié)果12次要終點：非癌癥相關死亡、LR-DFS、D-DF三、結(jié)果56發(fā)表偏倚Begg’stestP=0.25,Egger’stestP=0.24對OS的OR無影響三、結(jié)果13發(fā)表偏倚Begg’stestP=0.25,四、討論1、57四、討論1、14ClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.AddyourtextAddyourtextAddyourtextAddyourtextAddyourtextAddyourtext58ClicktoedittitlestyleThemeContentsClicktoaddtitleinhereClicktoaddtitleinhereClicktoaddtitleinhereClicktoaddtitleinhere4123ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.59ContentsClicktoaddtitleinHotTip

HowdoIincorporatemylogotoaslidethatwillapplytoalltheotherslides?

Onthe[View]menu,pointto[Master],andthenclick[SlideMaster]or[NotesMaster].Changeimagestotheoneyoulike,thenitwillapplytoalltheotherslides.[Imageinformationinproduct]Image:Notetocustomers:ThisimagehasbeenlicensedtobeusedwithinthisPowerPointtemplateonly.Youmaynotextracttheimageforanyotheruse.60HotTipHowdoIincorporatemClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.AddyourtextAddyourtextAddyourtextAddyourtextAddyourtextAddyourtext61ClicktoedittitlestyleThemeYourTextYourTextYourTextYourTextClicktoedittitlestyleYourTextYourTextYourTextYourText2005200620072008ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.62YourTextYourTextYourTextYouClicktoedittitlestyleDescriptionofthecontentsTextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.63ClicktoedittitlestyleDescClicktoedittitlestyleContents01Contents02Contents03Contents04Contents05Contents060%20%40%60%80%100%18.5%17.5%8.7%23.6%63.6%84.3%ThemeGallery

isaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.64ClicktoedittitlestyleConteClicktoedittitlestyleTextinhereTextinhereTextinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ClicktoaddText65ClicktoedittitlestyleTextClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.Titleinhere2.Descriptionofthecompany’ssubcontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.1.Descriptionofthecompany’ssubcontents66ClicktoedittitlestyleThemeClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleinhereTitleinhereTitleinhereTitleinhereABCD67ClicktoedittitlestyleTheme一、背景介紹DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsContentTitleContentTitleContentTitle68ATLAS一、背景介紹DescriptionofthecontClicktoedittitlestyleDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.ThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleinhereTitleinhereTitleinhere69ClicktoedittitlestyleDescrClicktoedittitlestyleTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereTextinhereContentsContentsContentsContentsContentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.70ClicktoedittitlestyleTextClicktoedittitlestyleDescribeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Describeavisionofcompanyorstrategiccontents.Descriptionoftheproducts71ClicktoedittitlestyleDescrPleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Pleasewritedownofasloganforavisionofacompanyinshortly.Vision01Vision03Vision02Vision04CompanyLOGOClicktoedittitlestyle72PleasewritedownofPleasewrClicktoedittitlestyleTitleinhereThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsTitleinhereTitleinhereTitleinhere73ClicktoedittitlestyleTitleService01Service02Service03LOGOThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.Clicktoedittitlestyle74Service01Service02Service03ClicktoedittitlestyleTitleinhereAddTitleAddTitleAddTitleAddTitleDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsTextinhereTextinhereTextinhereTextinhereDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontentsDescriptionofthecontents75ClicktoedittitlestyleTitleClicktoedittitlestyleThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.TitleTextinhereTextinhereTextinhereTextinhere76ClicktoedittitlestyleThemeClicktoedittitlestyleDescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.DescriptionofthecontentsThemeGalleryisaDesignDigitalContent&ContentsmalldevelopedbyGuildDesignInc.77ClicktoedittitlestyleDescClicktoedittitlestyleGrowthStartJump200820072006200520042003200220012000Descriptionofthecontents

Descriptionofthecontents

DescriptionofthecontentsDescriptionofthecontents

Descriptionofthecontents

DescriptionofthecontentsDescriptionofthecontents

Descriptionofthecontents

Descriptionofthecontents78ClicktoedittitlestyleGrowtDescriptionofthecontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecompany’stechnologyDescriptionofthecompany’scontentsDescriptionofthecompany’sproductsDescriptionofthecompany’sbusinessDescriptionofthecom