Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBRD-K98645985Cat.No.:HY-114268CASNo.:1357647-78-9分?式:C??H??N?O?分?量:573.73作?靶點:HIV作?通路:Anti-infection儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據體外實驗DMSO:250mg/mL(435.75mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.7430mL8.7149mL17.4298mL5mM0.3486mL1.7430mL3.4860mL10mM0.1743mL0.8715mL1.7430mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現(xiàn)?現(xiàn)配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(3.63mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:2.08mg/mL(3.63mM);Suspendedsolution;Needultrasonic3.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.63mM);ClearsolutionBIOLOGICALACTIVITY?物活性BRD-K98645985?種BAF(mammalianSWI/SNF)轉錄阻遏的抑制劑，EC50為~2.37μM。BRD-K98645985結合ARID1A特異的BAF復合物，防?核?體定位，并有效逆轉HIV-1潛伏期，并且?T細胞毒性。IC50&TargetBAFtranscriptionalrepressionHIV-12.37μM(EC50)體外研究BRD-K98645985(30μM;18hours)treatmentshowsa5-foldincreaseinBmi1,2.6-foldincreaseinRing1,and3.3-folddecreaseinFgf4[1].BRD-K98645985treatmentshowsaconcentrationdependentlatencyreversalinJ-LatT-celllinemodels.BRD-K98645985canbecombinedwithotherLRAstoimprovereservoirtargeting[1].戶使?本產品發(fā)表的科研?獻?Nature.2022Jul;607(7917):135-141.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].MarianCA,etal.SmallMoleculeTargetingofSpecificBAF(mSWI/SNF)ComplexesforHIVLatencyReversal.CellChemBiol.2018Dec20;25(12):1443-1455.e14.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: