Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECUR61414Cat.No.:HY-113965CASNo.:334998-36-6分?式:C??H??N?O?分?量:550.69作?靶點:Hedgehog;Smo;Apoptosis作?通路:StemCell/Wnt;Apoptosis儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(181.59mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.8159mL9.0795mL18.1590mL5mM0.3632mL1.8159mL3.6318mL10mM0.1816mL0.9080mL1.8159mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性CUR61414?種新型的可滲透細胞的Hedgehog信號通路抑制劑(IC50=100-200nM)，CUR61414氨脯氨酸類化合物的?分?成員，可選擇性結(jié)合Smoothened(Smo)，Ki值為44nM。CUR-61414可以誘導(dǎo)癌細胞凋亡(apoptosis)?不會響?癌癥細胞。IC50&TargetHedgehoginhibitor[1]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究CUR61414isabletoarrestproliferationofbasalcellswithintheBCC-likelesionsandinducecellstoundergoapoptosisresultingincompleteregressionofthelesions,withoutaffectingneighboringskincells[1].體內(nèi)研究CUR61414causeregressionoftheselesionsinthemice,whichareexposedtoUVlightirradiationfor6-9months,producingmanymicroscopicBCC-likebasaloidlesionsthroughouttheirskin.Moreover,asignificantincreaseinapoptoticnucleicanbeseeninbasaloidnestsafterCUR61414treatmentandnooverttoxicityisobservedintheskinsurroundingthelesions[1].戶使?本產(chǎn)品發(fā)表的科研?獻?ResearchSquarePreprint.2020Jun.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].WilliamsJA,etal.Identificationofasmallmoleculeinhibitorofthehedgehogsignalingpathway:effectsonbasalcellcarcinoma-likelesions.ProcNatlAcadSciUSA.2003Apr15;100(8):4616-21.Epub2003Apr4.[2].Frank-KamenetskyM,etal.Small-moleculemodulatorsofHedgehogsignaling:identificationandcharacterizationofSmoothenedagonistsandantagonists.JBiol.2002Nov6;1(2):10.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: