Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEMproinhibitorN3Cat.No.:HY-136149CASNo.:884650-98-0分?式:C??H??N?O?分?量:680.79作?靶點(diǎn):SARS-CoV;VirusProtease作?通路:Anti-infection儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:20mg/mL(29.38mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.4689mL7.3444mL14.6888mL5mM0.2938mL1.4689mL2.9378mL10mM0.1469mL0.7344mL1.4689mLBIOLOGICALACTIVITY?物活性MproinhibitorN3?種有效的SARS-CoV-2MPro抑制劑，EC50值為16.77μM。MproinhibitorN3顯?出針對(duì)HCoV-229E、FIPV和MHV-A59的抗病毒活性[1][2][3]。體外研究MproinhibitorN3(0-100μM)showsantiviralactivitieswithanEC50valueof16.77μMforSARS-CoV-2[1].MproinhibitorN3(0-50μM;14h)inhibitstheviralgrowthwiththeIC50valuesof4,8.8,2.7μMforHCoV-229E,FIPV,IBVandMHV-A59,respectively[2].體內(nèi)研究MproinhibitorN3(0-0.64μM;3,6h)showsantiviralactivityagainstIBVinchicken,embryos[3].AnimalModel:Chickenembryos[3]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEDosage:0-0.64μMAdministration:3,6hwith100-EID50titerofIBVM41virusResult:ShowedthatN3isabletopenetratecellstoinhibitthereplicationofIBVviruses,probablyatthebeginningofinfection,withthePD50of0.13μmolforthe3-hgroupand0.17μmolforthe6-hgroup.REFERENCES[1].JinZ,etal.StructureofMprofromSARS-CoV-2anddiscoveryofitsinhibitors.Nature.2020Jun;582(7811):289-293.[2].YangH,etal.Designofwide-spectruminhibitorstargetingcoronavirusmainproteases.PLoSBiol.2005Oct;3(10):e324.[3].XueX,etal.Structuresoftwocoronavirusmainproteases:implicationsforsubstratebindingandantiviraldrugdesign.JVirol.2008Mar;82(5):2515-27.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37