腫瘤上皮間質(zhì)轉(zhuǎn)化及其調(diào)控因素病理教研室施琳腫瘤上皮間質(zhì)轉(zhuǎn)化1上皮細(xì)胞是一種有粘聚性的細(xì)胞,組成上皮組織,覆蓋在機(jī)體表面和多個(gè)器官管腔內(nèi)表面。鱗癌、腺癌、移形上皮癌等上皮來源的惡性腫瘤歸屬此范疇。上皮細(xì)胞的特征:細(xì)胞之間有緊密連接,細(xì)胞與基底膜的附著有極性。具有相對(duì)穩(wěn)定和不可移動(dòng)性。立體權(quán)式圖上皮細(xì)胞是一種有粘聚性的細(xì)胞,組成上2間質(zhì)細(xì)胞是間質(zhì)及結(jié)締組織的主要組成成分,分散存在于細(xì)胞外基質(zhì)中間質(zhì)細(xì)胞的特正:結(jié)構(gòu)松散,佃胞相對(duì)沒有極性,間質(zhì)細(xì)胞是間3兩類細(xì)胞形態(tài)學(xué)差異由于各自的基因/蛋白表達(dá)差異兩類細(xì)胞形態(tài)學(xué)差異4上皮-間質(zhì)轉(zhuǎn)化(epithelialmesenchymaltransition,EMT)在胚胎形成和組織修復(fù)再生、器官纖維化等方面起著關(guān)鍵作用上皮-間質(zhì)轉(zhuǎn)化(epithelial5腫瘤上皮間質(zhì)轉(zhuǎn)化課件6腫瘤上皮間質(zhì)轉(zhuǎn)化課件7腫瘤上皮間質(zhì)轉(zhuǎn)化課件8腫瘤上皮間質(zhì)轉(zhuǎn)化課件9腫瘤上皮間質(zhì)轉(zhuǎn)化課件10腫瘤上皮間質(zhì)轉(zhuǎn)化課件11腫瘤上皮間質(zhì)轉(zhuǎn)化課件12腫瘤上皮間質(zhì)轉(zhuǎn)化課件13腫瘤上皮間質(zhì)轉(zhuǎn)化課件14腫瘤上皮間質(zhì)轉(zhuǎn)化課件15腫瘤上皮間質(zhì)轉(zhuǎn)化課件16腫瘤上皮間質(zhì)轉(zhuǎn)化課件17腫瘤上皮間質(zhì)轉(zhuǎn)化課件18腫瘤上皮間質(zhì)轉(zhuǎn)化課件19腫瘤上皮間質(zhì)轉(zhuǎn)化課件20腫瘤上皮間質(zhì)轉(zhuǎn)化課件21腫瘤上皮間質(zhì)轉(zhuǎn)化課件22腫瘤上皮間質(zhì)轉(zhuǎn)化課件23腫瘤上皮間質(zhì)轉(zhuǎn)化課件24腫瘤上皮間質(zhì)轉(zhuǎn)化課件25腫瘤上皮間質(zhì)轉(zhuǎn)化課件26腫瘤上皮間質(zhì)轉(zhuǎn)化課件27腫瘤上皮間質(zhì)轉(zhuǎn)化課件28腫瘤上皮間質(zhì)轉(zhuǎn)化課件29腫瘤上皮間質(zhì)轉(zhuǎn)化課件30腫瘤上皮間質(zhì)轉(zhuǎn)化課件31腫瘤上皮間質(zhì)轉(zhuǎn)化課件32腫瘤上皮間質(zhì)轉(zhuǎn)化課件33腫瘤上皮間質(zhì)轉(zhuǎn)化課件34腫瘤上皮間質(zhì)轉(zhuǎn)化課件35腫瘤上皮間質(zhì)轉(zhuǎn)化課件36腫瘤上皮間質(zhì)轉(zhuǎn)化課件37腫瘤上皮間質(zhì)轉(zhuǎn)化課件38腫瘤上皮間質(zhì)轉(zhuǎn)化課件39腫瘤上皮間質(zhì)轉(zhuǎn)化課件40腫瘤上皮間質(zhì)轉(zhuǎn)化課件41腫瘤上皮間質(zhì)轉(zhuǎn)化課件42腫瘤上皮間質(zhì)轉(zhuǎn)化課件43腫瘤上皮間質(zhì)轉(zhuǎn)化課件44腫瘤上皮間質(zhì)轉(zhuǎn)化課件45腫瘤上皮間質(zhì)轉(zhuǎn)化課件46腫瘤上皮間質(zhì)轉(zhuǎn)化課件47腫瘤上皮間質(zhì)轉(zhuǎn)化課件48腫瘤上皮間質(zhì)轉(zhuǎn)化課件49腫瘤上皮間質(zhì)轉(zhuǎn)化課件50腫瘤上皮間質(zhì)轉(zhuǎn)化課件51腫瘤上皮間質(zhì)轉(zhuǎn)化課件52腫瘤上皮間質(zhì)轉(zhuǎn)化課件53腫瘤上皮間質(zhì)轉(zhuǎn)化課件54腫瘤上皮間質(zhì)轉(zhuǎn)化課件55腫瘤上皮間質(zhì)轉(zhuǎn)化課件56腫瘤上皮間質(zhì)轉(zhuǎn)化課件57腫瘤上皮間質(zhì)轉(zhuǎn)化課件58腫瘤上皮間質(zhì)轉(zhuǎn)化課件59腫瘤上皮間質(zhì)轉(zhuǎn)化課件60腫瘤上皮間質(zhì)轉(zhuǎn)化課件61腫瘤上皮間質(zhì)轉(zhuǎn)化課件62腫瘤上皮間質(zhì)轉(zhuǎn)化課件63腫瘤上皮間質(zhì)轉(zhuǎn)化課件64腫瘤上皮間質(zhì)轉(zhuǎn)化課件65腫瘤上皮間質(zhì)轉(zhuǎn)化課件66腫瘤上皮間質(zhì)轉(zhuǎn)化課件67腫瘤上皮間質(zhì)轉(zhuǎn)化課件68腫瘤上皮間質(zhì)轉(zhuǎn)化課件69腫瘤上皮間質(zhì)轉(zhuǎn)化課件70腫瘤上皮間質(zhì)轉(zhuǎn)化課件71腫瘤上皮間質(zhì)轉(zhuǎn)化課件72腫瘤上皮間質(zhì)轉(zhuǎn)化課件73腫瘤上皮間質(zhì)轉(zhuǎn)化課件74腫瘤上皮間質(zhì)轉(zhuǎn)化課件75腫瘤上皮間質(zhì)轉(zhuǎn)化課件76腫瘤上皮間質(zhì)轉(zhuǎn)化課件77腫瘤上皮間質(zhì)轉(zhuǎn)化課件78腫瘤上皮間質(zhì)轉(zhuǎn)化課件79腫瘤上皮間質(zhì)轉(zhuǎn)化課