There?emergenceofnaturalproductsfordrugdiscoveryinthegenomicsera藥物基因組學(xué)教研室解鴻波There?emergenceofnaturalprNaturalproductsanddrugdiscoveryNaturalproductsandgenomicsFuturedirectionsandoutlookSourcesofNaturalproducts1234NaturalproductsanddrugdiscWhatarenaturalproducts?1.SourcesofNaturalproductsWhatarenaturalproducts?1.SWhatarenaturalproducts?1.SourcesofNaturalproductsWhatarenaturalproducts?1.S從基因到天然產(chǎn)物生物合成ppt課件從基因到天然產(chǎn)物生物合成ppt課件從基因到天然產(chǎn)物生物合成ppt課件Artemisinin2.NaturalproductsanddrugdiscoveryArtemisinin2.NaturalproductsMorphineQuininePaclitaxelMorphineQuininePaclitaxel6%27%25%5%37%Allsmallmoleculenewchemicalentities6%27%25%5%37%AllsmallmoleculCommerciallyavailablechemicalspace22x106compoundsNaturalproductuniverse16x104compoundsCommerciallyNaturalproductunNatural-productdatabasesDatabaseNumberofentriesAdditionalinformationSuperNaturalII355,0002DstructureswithvendorinformationUniversalNaturalProductDatabase197,2013DstructuresassembledfromotherdatabasesChineseNaturalProductDatabase53,000HasbeenusedinvirtualscreeniSMART20,000FromtraditionalChinesemedicinesAfroDb1,000FromAfricanmedicinalplantsNatural-productdatabasesDataInteractionsbetweendrugandtargetInteractionsbetweendrugand3.Naturalproductsandgenomics3.NaturalproductsandgenomiInsightsintotheBiosynthesisInsightsintotheBiosynthesisInsightsintotheBiosynthesisInsightsintotheBiosynthesisGeneclusterGenecluster從基因到天然產(chǎn)物生物合成ppt課件BioinformaticstoolsantiSMASH3.0BioinformaticstoolsantiSMASH從基因到天然產(chǎn)物生物合成ppt課件從基因到天然產(chǎn)物生物合成ppt課件DiscovernewdrugleadsDiscovernewdrugleadsDiscovernewdrugleadsDiscovernewdrugleadsPromoterreplacementsandgenedeletionsPromoterreplacementsandgene4.Futuredirectionsandoutlook“Therewasanintrinsicbeliefinthevalue