Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBC-7013Cat.No.:HY-113640CASNo.:1028291-66-8分?式:C??H??O?S分?量:500.69作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:4°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(199.72mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.9972mL9.9862mL19.9724mL5mM0.3994mL1.9972mL3.9945mL10mM0.1997mL0.9986mL1.9972mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性BC-7013?種半合成胸膜殘氨酸衍?物。BC-7013具有優(yōu)異的抗?蘭?陽性病原(bacteria)活性。BC-7013對(duì)葡萄球和鏈球和耐霉素肺炎鏈球均顯?出強(qiáng)?的抗特性。BC-7013具有抗?蘭?陽性病原活性，BC-7013可?于研究急性細(xì)性?膚及?膚結(jié)構(gòu)感染(ABSSSI)。IC50&TargetMIC50:0.015μg/mL(303testedS.aureusisolates)[2]1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE體外研究BC-7013showsstronginhibitoryactivityagainst303testedS.aureusisolateswithaMIC50valueof0.015μg/mL[2].BC-7013exhibitspotentactivityagainstgroupAstreptococciandgroupBstreptococciwithMIC90svaluesof0.03μg/mLand0.06μg/mL,respectively[2].REFERENCES[1].ShangR,etal.Efficientantibacterialagents:areviewofthesynthesis,biologicalevaluationandmechanismofpleuromutilinderivatives.CurrTopMedChem.2013;13(24):3013-25.[2].BiedenbachDJ,etal.InvitroantibacterialspectrumofBC-7013,anovelpleuromutilinderivativefortopicaluseinhumans.InterscienceConferenceonAntimicrobialAgentsandChemotherapy.2009,49:199McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0