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TableofPharmacogenomicBiomarkersinDrugLabeling
Pharmacogenomicscanplayanimportantroleinidentifyingrespondersandnon-responderstomedications,avoidingadverseevents,andoptimizingdrugdose.Druglabelingmaycontaininformationongenomicbiomarkersandcandescribe:
Drugexposureandclinicalresponsevariability
Riskforadverseevents
Genotype-specificdosing
Mechanismsofdrugaction
Polymorphicdrugtargetanddispositiongenes
ThetablebelowlistsFDA-approveddrugswithpharmacogenomicinformationintheirlabeling.Thelabelingforsome,butnotall,oftheproductsincludesspecificactionstobetakenbasedonthebiomarkerinformation.Pharmacogenomicinformationcanappearindifferentsectionsofthelabelingdependingontheactions.Formoreinformation,pleaserefertotheappropriatelabelingguidance.
Biomarkersinthetableincludebutarenotlimitedtogerm-lineorsomaticgenevariants,functionaldeficiencies,expressionchanges,andchromosomalabnormalities;selectedproteinbiomarkersthatareusedtoselectpatientsfortreatmentarealsoincluded.
Thistabledoesnotincludenon-humangeneticbiomarkers(e.g.,microbialvariantsthatinfluencesensitivitytoantibiotics),orbiomarkersthatareusedsolelyfordiagnosticpurposes(e.g.,forgeneticdiseases)unlesstheyarelinkedtodrugactivityorusedtoidentifyaspecificsubsetinwhomprescribinginformationdiffers.Fordrugsthatareavailableinmultipledosageforms,salts,orcombinations,asinglerepresentativeproductislisted.Inthecaseofcombinationproducts,thesingleagentassociatedwiththebiomarkerislistedunlesstheagentisonlyapprovedasacombinationproduct,inwhichcaseallagentsarelisted.
PharmacogenomicBiomarkersinDrugLabeling
Drug
TherapeuticArea*
Biomarker?
ReferencedSubgroup?
LabelingSections
Abacavir
InfectiousDiseases
HLA-B
HLA-B*5701allelecarriers
BoxedWarning,Contraindications,WarningsandPrecautions
Ado-TrastuzumabEmtansine
Oncology
ERBB2
HER2proteinoverexpressionorgeneamplificationpositive
IndicationsandUsage,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Afatinib
Oncology
EGFR
EGFRexon19deletionorexon21substitution(L858R)positive
IndicationsandUsage,DosageandAdministration,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Alectinib
Oncology
ALK
ALKgenerearrangementpositive
IndicationsandUsage,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Alirocumab
Endocrinology
LDLR
LDLreceptormutationheterozygotes
IndicationsandUsage,AdverseReactions,ClinicalStudies
Amitriptyline
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Anastrozole
Oncology
ESR1,PGR
Hormonereceptorpositive
IndicationsandUsage,AdverseReactions,DrugInteractions,ClinicalStudies
Arformoterol(1)
Pulmonary
UGT1A1
UGT1A1poormetabolizers
ClinicalPharmacology
Arformoterol(2)
Pulmonary
CYP2D6
CYP2D6intermediateorpoormetabolizers
ClinicalPharmacology
Aripiprazole
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,UseinSpecificPopulations,DrugInteractions,ClinicalPharmacology
AripiprazoleLauroxil
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,UseinSpecificPopulations,ClinicalPharmacology
ArsenicTrioxide
Oncology
PML-RARA
PML-RARαtranslocationpositive
ClinicalPharmacology,IndicationsandUsage
Atomoxetine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,WarningsandPrecautions,DrugInteractions,ClinicalPharmacology
Azathioprine
Rheumatology
TPMT
TPMTintermediateorpoormetabolizers
ClinicalPharmacology,Warnings,Precautions,DrugInteractions,AdverseReactions,DosageandAdministration
Belinostat
Oncology
UGT1A1
UGT1A1*28allelehomozygotes
DosageandAdministration,ClinicalPharmacology
Blinatumomab
Oncology
BCR-ABL1
Philadelphiachromosomenegative
IndicationsandUsage,ClinicalStudies
Boceprevir
InfectiousDiseases
IFNL3
IL28Brs12979860Tallelecarriers(C/TandT/Tgenotype)
ClinicalPharmacology
Bosutinib
Oncology
BCR-ABL1
Philadelphiachromosomepositive
IndicationsandUsage,AdverseReactions,UseinSpecificPopulations,ClinicalStudies
Brexpiprazole
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,DrugInteractions,UseinSpecificPopulations,ClinicalPharmacology
Busulfan
Oncology
BCR-ABL1
Philadelphiachromosomenegative
ClinicalStudies
Cabozantinib
Oncology
RET
RETmutationpositive
ClinicalStudies
Capecitabine
Oncology
DPYD
DPDdeficient
WarningsandPrecautions,PatientCounselingInformation
Carbamazepine(1)
Neurology
HLA-B
HLA-B*1502allelecarriers
BoxedWarning,Warnings,Precautions
Carbamazepine(2)
Neurology
HLA-A
HLA-A*3101allelecarriers
Warnings
CarglumicAcid
InbornErrorsofMetabolism
NAGS
N-acetylglutamatesynthasedeficient
IndicationsandUsage,WarningsandPrecautions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Carisoprodol
Rheumatology
CYP2C19
CYP2C19poormetabolizers
UseinSpecificPopulations,ClinicalPharmacology
Carvedilol
Cardiology
CYP2D6
CYP2D6poormetabolizers
DrugInteractions,ClinicalPharmacology
Celecoxib
Rheumatology
CYP2C9
CYP2C9poormetabolizers
DosageandAdministration,UseinSpecificPopulations,ClinicalPharmacology
Ceritinib
Oncology
ALK
ALKgenerearrangementpositive
IndicationsandUsage,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Cetuximab(1)
Oncology
EGFR
EGFRproteinexpressionpositive
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Cetuximab(2)
Oncology
KRAS
KRAScodon12and13mutationnegative
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Cevimeline
Dental
CYP2D6
CYP2D6poormetabolizers
Precautions
Chloroquine
InfectiousDiseases
G6PD
G6PDdeficient
Precautions
Chlorpropamide
Endocrinology
G6PD
G6PDdeficient
Precautions
CholicAcid
InbornErrorsofMetabolism
AKR1D1,HSD3B7,CYP27A1,AMACR,CYP7A1
Bileacidsynthesisenzymedeficient
IndicationsandUsage,WarningsandPrecautions,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Cisplatin
Oncology
TPMT
TPMTintermediateorpoormetabolizers
AdverseReactions
Citalopram(1)
Psychiatry
CYP2C19
CYP2C19poormetabolizers
ClinicalPharmacology,Warnings,DosageandAdministration
Citalopram(2)
Psychiatry
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Clobazam
Neurology
CYP2C19
CYP2C19poormetabolizers
DosageandAdministration,UseinSpecificPopulations,ClinicalPharmacology
Clomipramine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Clopidogrel
Cardiology
CYP2C19
CYP2C19intermediateorpoormetabolizers
BoxedWarning,DosageandAdministration,WarningsandPrecautions,ClinicalPharmacology
Clozapine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,UseinSpecificPopulations,ClinicalPharmacology
Cobimetinib
Oncology
BRAF
BRAFV600E/Kmutationpositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Codeine
Anesthesiology
CYP2D6
CYP2D6ultrarapidmetabolizers
BoxedWarning,WarningsandPrecautions,UseinSpecificPopulations,PatientCounselingInformation
Crizotinib
Oncology
ALK
ALKgenerearrangementpositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Dabrafenib(1)
Oncology
BRAF
BRAFV600E/Kmutationpositive
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies,PatientCounselingInformation
Dabrafenib(2)
Oncology
G6PD
G6PDdeficient
WarningsandPrecautions,AdverseReactions,PatientCounselingInformation
Dapsone(1)
Dermatology
G6PD
G6PDdeficient
WarningsandPrecautions,UseinSpecificPopulations,PatientCounselingInformation
Dapsone(2)
InfectiousDiseases
G6PD
G6PDdeficient
Precautions,AdverseReactions,Overdosage
Dasatinib
Oncology
BCR-ABL1
Philadelphiachromosomepositive,T315Imutationpositive
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
DenileukinDiftitox
Oncology
IL2RA
CD25antigenpositive
IndicationsandUsage,WarningsandPrecautions,ClinicalStudies
Desipramine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Dexlansoprazole
Gastroenterology
CYP2C19
CYP2C19poormetabolizers
DrugInteractions,ClinicalPharmacology
DextromethorphanandQuinidine
Neurology
CYP2D6
CYP2D6poormetabolizers
WarningsandPrecautions,ClinicalPharmacology
Diazepam
Neurology
CYP2C19
CYP2C19poormetabolizers
ClinicalPharmacology
Dinutuximab
Oncology
MYCN
MYCNamplificationpositive
ClinicalStudies
Dolutegravir
InfectiousDiseases
UGT1A1
UGT1A1poormetabolizers
ClinicalPharmacology
Doxepin(1)
Psychiatry
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Doxepin(2)
Psychiatry
CYP2C19
CYP2C19poormetabolizers
ClinicalPharmacology
DrospirenoneandEthinylEstradiol
Gynecology
CYP2C19
CYP2C19intermediatemetabolizers
ClinicalPharmacology
Eliglustat
InbornErrorsofMetabolism
CYP2D6
CYP2D6ultrarapid,intermediateorpoormetabolizers
IndicationsandUsage,DosageandAdministration,Contraindications,WarningsandPrecautions,DrugInteractions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Elosulfase
InbornErrorsofMetabolism
GALNS
N-acetylgalactosamine-6-sulfatasedeficient
IndicationsandUsage,WarningsandPrecautions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Eltrombopag(1)
Hematology
F5
FactorVLeidencarriers
WarningsandPrecautions
Eltrombopag(2)
Hematology
SERPINC1
AntithrombinIIIdeficient
WarningsandPrecautions
Erlotinib(1)
Oncology
EGFR
EGFRproteinexpressionpositive
ClinicalStudies
Erlotinib(2)
Oncology
EGFR
EGFRexon19deletionorexon21substitution(L858R)positive
IndicationsandUsage,DosageandAdministration,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Escitalopram(1)
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DrugInteractions
Escitalopram(2)
Psychiatry
CYP2C19
CYP2C19poormetabolizers
AdverseReactions
Esomeprazole
Gastroenterology
CYP2C19
CYP2C19poormetabolizers
DrugInteractions,ClinicalPharmacology
Everolimus(1)
Oncology
ERBB2
HER2proteinoverexpressionnegative
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,DrugInteractions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Everolimus(2)
Oncology
ESR1
Estrogenreceptorpositive
ClinicalStudies
Evolocumab
Endocrinology
LDLR
LDLreceptormutationheterozygotesandhomozygotes
IndicationsandUsage,DosageandAdministration,AdverseReactions,UseinSpecificPopulations,ClinicalStudies
Exemestane(1)
Oncology
ESR1
Estrogenreceptorpositive
IndicationsandUsage,DosageandAdministration,ClinicalStudies
Exemestane(2)
Oncology
PGR
Progesteronereceptorpositive
ClinicalStudies
Fesoterodine
Urology
CYP2D6
CYP2D6poormetabolizers
DrugInteractions,ClinicalPharmacology
Fluorouracil(1)
Dermatology
DPYD
DPDdeficient
Contraindications,Warnings
Fluorouracil(2)
Oncology
DPYD
DPDdeficient
Warnings
Fluoxetine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
WarningsandPrecautions,DrugInteractions,ClinicalPharmacology
Flurbiprofen
Rheumatology
CYP2C9
CYP2C9poormetabolizers
ClinicalPharmacology
Fluvoxamine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DrugInteractions
Fulvestrant
Oncology
ESR1,PGR
Hormonereceptorpositive
IndicationsandUsage,ClinicalPharmacology,ClinicalStudies
Galantamine
Neurology
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Gefitinib
Oncology
EGFR
EGFRexon19deletionsorexon21substitution(L858R)mutationpositive
IndicationsandUsage,DosageandAdministration,ClinicalPharmacology,ClinicalStudies
Glimepiride
Endocrinology
G6PD
G6PDdeficient
WarningsandPrecautions,AdverseReactions
Glipizide
Endocrinology
G6PD
G6PDdeficient
Precautions
Glyburide
Endocrinology
G6PD
G6PDdeficient
Precautions
Hydralazine
Cardiology
NAT1-2
NAT1-2slowacetylators
ClinicalPharmacology
Ibrutinib
Oncology
del(17p)
Chromosome17pdeletionpositive
IndicationsandUsage,ClinicalStudies
Iloperidone
Psychiatry
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,WarningsandPrecautions,DrugInteractions,ClinicalPharmacology
Imatinib(1)
Oncology
KIT
KITproteinexpressionpositive,c-KITD816Vmutationnegative
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Imatinib(2)
Oncology
BCR-ABL1
Philadelphiachromosomepositive
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Imatinib(3)
Oncology
PDGFRB
PDGFRgenerearrangementpositive
IndicationsandUsage,DosageandAdministration,ClinicalStudies
Imatinib(4)
Oncology
FIP1L1-PDGFRA
FIP1L1-PDGFRαfusionkinase(orCHIC2deletion)positive
IndicationsandUsage,DosageandAdministration,ClinicalStudies
Imipramine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Indacaterol
Pulmonary
UGT1A1
UGT1A1*28allelehomozygotes
ClinicalPharmacology
Irinotecan
Oncology
UGT1A1
UGT1A1*28allelecarriers
DosageandAdministration,WarningsandPrecautions,ClinicalPharmacology
Ivacaftor
Pulmonary
CFTR
CFTRG551D,G1244E,G1349D,G178R,G551S,S1251N,S1255P,S549N,S549R,R117Hmutationpositive,F508delmutationhomozygotes
IndicationsandUsage,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Lacosamide
Neurology
CYP2C19
CYP2C19poormetabolizers
ClinicalPharmacology
Lansoprazole
Gastroenterology
CYP2C19
CYP2C19intermediateorpoormetabolizers
DrugInteractions
Lapatinib(1)
Oncology
ERBB2
HER2proteinoverexpressionpositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Lapatinib(2)
Oncology
HLA-DQA1,HLA-DRB1
HLA-DQA1*0201orHLA-DRB1*0701allelecarriers
ClinicalPharmacology
Lenalidomide
Hematology
del(5q)
Chromosome5qdeletionpositive
BoxedWarning,IndicationsandUsage,AdverseReactions,UseinSpecificPopulations,ClinicalStudies
Lesinurad
Rheumatology
CYP2C9
CYP2C9poormetabolizers
ClinicalPharmacology
Letrozole
Oncology
ESR1,PGR
Hormonereceptorpositive
IndicationsandUsage,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Lomitapide
Endocrinology
LDLR
LDLreceptormutationhomozygotes
IndicationandUsage,WarningsandPrecautions,AdverseReactions,ClinicalStudies
IvacaftorandLumacaftor
Pulmonary
CFTR
CFTRF508delmutationhomozygotes
IndicationsandUsage,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Mafenide
InfectiousDiseases
G6PD
G6PDdeficient
Warnings,AdverseReactions
Mercaptopurine
Oncology
TPMT
TPMTintermediateorpoormetabolizers
ClinicalPharmacology,Warnings,Precautions,AdverseReactions,DosageandAdministration
MethyleneBlue
Hematology
G6PD
G6PDdeficient
Precautions
Metoclopramide(1)
Gastroenterology
CYB5R1-4
NADHcytochromeb5reductasedeficient
Precautions
Metoclopramide(2)
Gastroenterology
G6PD
G6PDdeficient
Precautions
Metoprolol
Cardiology
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Mipomersen
Endocrinology
LDLR
LDLreceptormutationheterozygotesandhomozygotes
IndicationsandUsage,WarningsandPrecautions,AdverseReactions,UseinSpecificPopulations,ClinicalStudies
Modafinil
Psychiatry
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology,Precautions
MycophenolicAcid
Transplantation
HPRT1
HGPRTdeficient
WarningsandPrecautions
NalidixicAcid
InfectiousDiseases
G6PD
G6PDdeficient
Precautions,AdverseReactions
Nefazodone
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Nilotinib(1)
Oncology
BCR-ABL1
Philadelphiachromosomepositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Nilotinib(2)
Oncology
UGT1A1
UGT1A1*28allelehomozygotes
ClinicalPharmacology
Nitrofurantoin
InfectiousDiseases
G6PD
G6PDdeficient
Warnings,AdverseReactions
Nivolumab(1)
Oncology
BRAF
BRAFV600mutationpositive
IndicationsandUsage,AdverseReactions,ClinicalStudies
Nivolumab(2)
Oncology
CD274
PD-L1proteinexpressionpositive
ClinicalPharmacology
Nortriptyline
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Obinutuzumab
Oncology
MS4A1
CD20antigenpositive
ClinicalStudies
Olaparib
Oncology
BRCA1-2
BRCA1-2mutationpositive
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Omacetaxine
Oncology
BCR-ABL1
Philadelphiachromosomepositive
ClinicalPharmacology,ClinicalStudies
Ombitasvir,
Paritaprevir,Ritonavir,andDasabuvir
InfectiousDiseases
IFNL3
IL28Brs12979860Tallelecarriers(non-C/Cgenotype)
ClinicalStudies
Omeprazole
Gastroenterology
CYP2C19
CYP2C19poormetabolizers
DrugInteractions
Osimertinib
Oncology
EGFR
EGFRT790Mmutationpositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Palbociclib(1)
Oncology
ESR1
Estrogenreceptorpositive
IndicationsandUsage,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Palbociclib(2)
Oncology
ERBB2
HER2proteinoverexpressionnegative
IndicationsandUsage,AdverseReactions,ClinicalStudies
Palonosetron
Gastroenterology
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Panitumumab(1)
Oncology
EGFR
EGFRproteinexpressionpositive
ClinicalPharmacology,ClinicalStudies
Panitumumab(2)
Oncology
KRAS
KRAScodon12and13mutationnegative
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Pantoprazole
Gastroenterology
CYP2C19
CYP2C19poormetabolizers
ClinicalPharmacology
ParathyroidHormone
InbornErrorsofMetabolism
CASR
Calciumsensingreceptormutationpositive
IndicationsandUsage,ClinicalStudies
Paroxetine
Psychiatry
CYP2D6
CYP2D6extensiveandpoormetabolizers
DrugInteractions,ClinicalPharmacology
Pazopanib
Oncology
UGT1A1
UGT1A1*28allelehomozygotes
ClinicalPharmacology,WarningsandPrecautions
PEG-3350,SodiumSulfate,SodiumChloride,PotassiumChloride,SodiumAscorbate,andAscorbicAcid
Gastroenterology
G6PD
G6PDdeficient
WarningsandPrecautions
Pegloticase
Rheumatology
G6PD
G6PDdeficient
Contraindications,PatientCounselingInformation
Pembrolizumab(1)
Oncology
BRAF
BRAFV600mutationpositive
IndicationsandUsage,AdverseReactions,ClinicalStudies
Pembrolizumab(2)
Oncology
CD274
PD-L1proteinexpressionpositive
IndicationsandUsage,DosageandAdministration,ClinicalPharmacology,ClinicalStudies
Perphenazine
Psychiatry
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology,Precautions
Pertuzumab
Oncology
ERBB2
HER2proteinoverexpressionpositive
IndicationsandUsage,WarningsandPrecautions,AdverseReactions,ClinicalPharmacology,ClinicalStudies
Phenytoin(1)
Neurology
CYP2C9
CYP2C9variantallelecarriers
ClinicalPharmacology
Phenytoin(2)
Neurology
CYP2C19
CYP2C19variantallelecarriers
ClinicalPharmacology
Phenytoin(3)
Neurology
HLA-B
HLA-B*1502allelecarriers
Warnings
Pimozide
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions,DosageandAdministration
Ponatinib
Oncology
BCR-ABL1
Philadelphiachromosomepositive;T315Imutationpositive
IndicationsandUsage,WarningsandPrecautions,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Prasugrel(1)
Cardiology
CYP2C19
CYP2C19poormetabolizers
UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Prasugrel(2)
Cardiology
CYP2C9
CYP2C9variantallelecarriers
UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Prasugrel(3)
Cardiology
CYP3A5
CYP3A5variantallelecarriers
UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Prasugrel(4)
Cardiology
CYP2B6
CYP2B6variantallelecarriers
UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Pravastatin
Endocrinology
LDLR
LDLreceptormutationheterozygotesandhomozygotes
IndicationsandUsage,UseinSpecificPopulations,ClinicalStudies
PrilocaineandLidocaine(1)
Anesthesiology
CYB5R1-4
NADHcytochromeb5reductasedeficient
WarningsandPrecautions
PrilocaineandLidocaine(2)
Anesthesiology
G6PD
G6PDdeficient
WarningsandPrecautions
Primaquine
InfectiousDiseases
G6PD
G6PDdeficient
WarningsandPrecautions,AdverseReactions
Propafenone
Cardiology
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,WarningsandPrecautions,ClinicalPharmacology
Propranolol
Cardiology
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Protriptyline
Psychiatry
CYP2D6
CYP2D6poormetabolizers
Precautions
Quinidine
Cardiology
CYP2D6
CYP2D6poormetabolizers
Precautions
QuinineSulfate(1)
InfectiousDiseases
G6PD
G6PDdeficient
Contraindications
QuinineSulfate(2)
InfectiousDiseases
CYP2D6
CYP2D6poormetabolizers
DrugInteractions
Rabeprazole
Gastroenterology
CYP2C19
CYP2C19poormetabolizers
DrugInteractions,ClinicalPharmacology
Rasburicase(1)
Oncology
G6PD
G6PDdeficient
BoxedWarning,Contraindications,WarningsandPrecautions
Rasburicase(2)
Oncology
CYB5R1-4
NADHcytochromeb5reductasedeficient
BoxedWarning,WarningsandPrecautions
Rifampin,Isoniazid,andPyrazinamide
InfectiousDiseases
NAT1-2
NAT1-2slowacetylators
ClinicalPharmacology,AdverseReactions
Risperidone
Psychiatry
CYP2D6
CYP2D6poormetabolizers
ClinicalPharmacology
Rituximab
Oncology
MS4A1
CD20antigenpositive
IndicationsandUsage,DosageandAdministration,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Rosuvastatin(1)
Endocrinology
SLCO1B1
SLCO1B1reducedfunctionallelehomozygotes
ClinicalPharmacology
Rosuvastatin(2)
Endocrinology
LDLR
LDLreceptormutationheterozygotesandhomozygotes
IndicationsandUsage,DosageandAdministration,AdverseReactions,UseinSpecificPopulations,ClinicalPharmacology,ClinicalStudies
Sevoflurane
Anesthesiology
RYR1
Ryanodinereceptormutationpositive
Warnings
Simeprevir
InfectiousDiseases
IFNL3
IL28Brs12979860Tallelecarriers(non-C/Cgenotype)
ClinicalPharmacology,ClinicalStudies
SodiumNitrite
Toxicology
G6PD
G6PDdeficient
WarningsandPrecautions
SodiumPhenylacetateandSodiumBenzoate
InbornErrorsofMetabolism
NAGS,CPS1,ASS1,OTC,ASL,ABL2
Ureacycleenzymedeficient
IndicationsandUsage,DosageandAdministration,WarningsandPrecautions,AdverseReactions,DrugInteractions,UseinSpecificPopulations,Overdosage,ClinicalPharmacology,ClinicalStudies
Sofosbuvir
InfectiousDiseases
IFNL3
IL28Brs12979860Tallelecarriers(non-C/Cgenotype)
ClinicalStudies
Succimer
Hematology
G6PD
G6PDdeficient
ClinicalPharmacology
SulfamethoxazoleandTrimethoprim
InfectiousDiseases
G6PD
G6PDdeficient
Precautions
Tamoxifen(1)
Oncology
ESR1,PGR
Hormonereceptorpositive
ClinicalPharmacology,IndicationsandUsage,Precautions,AdverseReactions
Tamoxifen(2)
Oncology
F5
FactorVLeidencarriers
Warnings
Tamoxifen(3)
Oncology
F2
ProthrombinG0Aallelepositive
Warnings
Telaprevir
InfectiousDiseases
IFNL3
IL28Brs12979860Tallelecarriers(C/TandT/Tgenotype)
ClinicalPharmacology,ClinicalStudies
Tetrabenazine
Neurology
CYP2D6
CYP2D6poormetabolizers
DosageandAdministration,WarningsandPrecautions,UseinSpecificPopulations,ClinicalPharmacology
Thioguanine
Oncology
TPMT
TPMTintermediateorpoormetabolizers
Warn
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