SF/ZJD0107005——2016血液、尿液中238種毒(藥)物的檢測

液相色譜-串聯(lián)質(zhì)譜法1范圍本技術(shù)規(guī)范規(guī)定了血液或尿液中阿片類、苯丙胺類、大麻酚類濫用藥物，有機磷及氨基甲酸酯類殺蟲劑、苯二氮卓類、抗抑郁類、抗癲癇類、平喘類、解熱鎮(zhèn)痛類藥物以及其它常見治療藥物共238種毒（藥）物（見附錄A）的液相色譜-串聯(lián)質(zhì)譜（LC-MS/MS）檢驗方法。本技術(shù)規(guī)范適用于血液或尿液中阿片類、苯丙胺類、大麻酚類濫用藥物，有機磷類及氨基甲酸酯類殺蟲劑、苯二氮卓類、抗抑郁類、抗癲癇類、平喘類、解熱鎮(zhèn)痛類藥物以及其它常見治療藥物共238種毒（藥）物的定性定量分析。也適用于體外樣品、可疑物證中238種毒（藥）物的定性分析。2規(guī)范性引用文件下列文件中對本技術(shù)規(guī)范的應(yīng)用是必不可少的。凡是注日期的引用文件，僅所注日期的版本適用于本技術(shù)規(guī)范。凡是不注日期的引用文件，其最新版本（包括所有的修改單）適用于本技術(shù)規(guī)范。GA/T122毒物分析名詞術(shù)語GB/T6682分析實驗室用水規(guī)格和試驗方法3術(shù)語和定義GA/T122中界定的術(shù)語和定義適用于本技術(shù)規(guī)范。4原理本技術(shù)規(guī)范利用阿片類、苯丙胺類、大麻酚類濫用藥物，有機磷及氨基甲酸酯類殺蟲劑、苯二氮卓類、抗抑郁類、抗癲癇類、平喘類、解熱鎮(zhèn)痛類以及其他常見治療藥物共238種毒（藥）物可在堿性條件下被有機溶劑從生物檢材中提取出來的特點，利用LC-MS/MS多反應(yīng)監(jiān)測進(jìn)行檢測。經(jīng)與平行操作的毒（藥）物對照品比較，以保留時間、兩對母離子/子離子對進(jìn)行定性分析；以定量離子對峰面積為依據(jù)，內(nèi)標(biāo)法或外標(biāo)法定量。5試劑和儀器5.1試劑5.1.1乙腈。5.1.2乙醚：分析純。5.1.3乙酸胺。5.1.4甲酸(50%)：優(yōu)級純。5.1.5超純水：由純水系統(tǒng)制得，電阻率18.2MΩ·cm。5.1.6pH9.2硼砂緩沖液。5.1.720mmol/L乙酸胺和0.1%甲酸緩沖液：分別稱取1.54g乙酸銨和1.84g甲酸，置于1000mL容量瓶中，加水至刻度，搖勻備用，pH值約為4。5.1.8238種毒(藥)物對照品標(biāo)準(zhǔn)溶液：分別精密稱取238種毒(藥)物對照品各適量，用甲醇配成1.0mg/mL對照品標(biāo)準(zhǔn)儲備溶液，置冰箱中冷凍保存，保存時間為12個月。試驗中所用其它濃度的對照品標(biāo)準(zhǔn)溶液均從上述儲備液用甲醇稀釋而得。5.1.9內(nèi)標(biāo)物地西泮-d5和SKF525A對照品標(biāo)準(zhǔn)溶液：精密稱取地西泮-d5和SKF525A適量，用甲醇配制成1.0mg/mL地西泮-d5和SKF525A對照品混合標(biāo)準(zhǔn)儲備溶液，置冰箱中冷凍保存，保存時間為12個月。將儲備液用甲醇稀釋得1μg/mL地西泮-d5和SKF525A內(nèi)標(biāo)工作液，置冰箱中冷藏保存，保存時間為6個月。注：本技術(shù)規(guī)范所用試劑除另有說明外均為色譜純，試驗用水為一級水（見GB/T6682規(guī)定）。5.2儀器5.2.1液相色譜-串聯(lián)質(zhì)譜聯(lián)用儀（LC-MS/MS）：配有電噴霧離子源。5.2.2旋渦混合器。5.2.3離心機。5.2.4恒溫水浴鍋。5.2.5精密移液器。5.2.6具塞離心試管。5.2.7分析天平：感量0.1mg。6測定步驟6.1樣品預(yù)處理6.1.1待測樣品取血液或尿液1mL，加入10mL地西泮-d5和SKF525A內(nèi)標(biāo)溶液（1μg/mL），加入2mLpH9.2硼酸緩沖液后用3.5mL乙醚提取，混旋，離心。上清液于60C水浴中揮干，殘余物中加入200mL流動相復(fù)溶，取10mL進(jìn)LC-MS/MS分析。6.1.2空白樣品取空白血液或尿液1mL，按“6.1.1”項下進(jìn)行操作和分析。6.1.3添加樣品取空白血液或尿液1mL，添加待測樣品中出現(xiàn)的可疑毒（藥）物對照品，按“6.1.1”項下進(jìn)行操作和分析。6.2測定6.2.1LC-MS/MS參考條件以下為參考條件，可根據(jù)不同品牌儀器和不同樣品等實際情況進(jìn)行調(diào)整：a）液相柱：AllurePFPPropyl100mm2.1mm5m或相當(dāng)者，接C18保護(hù)柱；b）流動相：乙腈:20mmol/L乙酸銨和0.1%甲酸緩沖液（70:30）；c）流速：200L/min；d）進(jìn)樣量：10L；e）離子源：電噴霧電離-正離子模式（ESI+）；f）檢測方式：多反應(yīng)監(jiān)測（MRM）；g）碰撞氣（CAD）、氣簾氣（CUR）、霧化氣（GS1）、輔助加熱氣均為高純氮氣，使用前調(diào)節(jié)各氣流流量以使質(zhì)譜靈敏度達(dá)到檢測要求；h）去簇電壓（DP）、碰撞能量（CE）等電壓值應(yīng)優(yōu)化至最優(yōu)靈敏度，參見附錄A。6.2.2定性分析篩選篩選分析選取毒（藥）物的第一對母離子/子離子。如果待測樣品的MRM色譜圖中出現(xiàn)峰高超過5000的色譜峰，則記錄該峰的保留時間和對應(yīng)的母離子/子離子對，由附錄A篩選出可疑的毒（藥）物，并進(jìn)行空白添加實驗，進(jìn)行確證分析。確證重新設(shè)定LC-MS/MS條件，按照附錄A增加可疑毒（藥）物的第二對母離子/子離子。如果待測樣品出現(xiàn)可疑毒（藥）物兩對母離子/子離子對的特征色譜峰，保留時間與添加樣品中相應(yīng)對照品的色譜峰保留時間比較，相對誤差在±2.5%內(nèi)，且所選擇的離子對相對豐度比與添加對照品的離子對相對豐度比之相對誤差不超過表1規(guī)定的范圍，則可認(rèn)為待測樣品中檢出此種毒（藥）物成分。表1相對離子對豐度比的最大允許相對誤差(%)相對離子對豐度比≥502050102010允許的相對誤差202530506.2.3定量分析定量方法根據(jù)待測樣品中毒（藥）物的濃度情況，用空白血液或尿液添加相應(yīng)毒（藥）物對照品，采用內(nèi)標(biāo)法或外標(biāo)法，以定量離子對峰面積進(jìn)行定量測定。定量方法可采用工作曲線法或單點校正法。采用工作曲線法時待測樣品中毒（藥）物的濃度應(yīng)在工作曲線的線性范圍內(nèi)。配制系列濃度的毒（藥）物血液或尿液質(zhì)控樣品，按“6.1.1”進(jìn)行樣品處理，按“6.2.1”條件進(jìn)行測定，以毒（藥）物和內(nèi)標(biāo)定量離子對峰面積比[或毒（藥）物定量離子對峰面積]為縱坐標(biāo)，血液或尿液中毒（藥）物濃度為橫坐標(biāo)繪制工作曲線，用工作曲線對待測樣品中毒（藥）物濃度進(jìn)行定量。采用單點校正法時待測樣品中毒（藥）物的濃度應(yīng)在添加樣品中毒（藥）物濃度的50%內(nèi)。結(jié)果計算.1內(nèi)標(biāo)-工作曲線法在系列濃度的毒（藥）物血液或尿液質(zhì)控樣品中，以毒（藥）物與內(nèi)標(biāo)定量離子對的峰面積比（Y）為縱坐標(biāo)、毒（藥）物質(zhì)量濃度（C）為橫坐標(biāo)進(jìn)行線性回歸，得線性方程。

根據(jù)待測樣品中毒（藥）物與內(nèi)標(biāo)定量離子對峰面積比，按公式（1）計算出待測樣品中毒（藥）物的質(zhì)量濃度。 ………………（1）式中：C??待測樣品中毒（藥）物質(zhì)量濃度，單位為納克每毫升（ng/mL）；Y??待測樣品中毒（藥）物與內(nèi)標(biāo)峰面積比；a??線性方程的截距；b??線性方程的斜率。.2內(nèi)標(biāo)-單點校正法根據(jù)待測樣品及添加樣品中毒（藥）物與內(nèi)標(biāo)定量離子對峰面積比，按公式（2）計算出待測樣品中毒（藥）物的質(zhì)量濃度。 ………………（2）式中：C??待測樣品中毒（藥）物質(zhì)量濃度，單位為納克每毫升(ng/mL)；A??待測樣品中毒（藥）物的峰面積；A′??添加樣品中毒（藥）物的峰面積；Ai??待測樣品中內(nèi)標(biāo)的峰面積；Ai′??添加樣品中內(nèi)標(biāo)的峰面積；c??添加樣品中毒（藥）物的質(zhì)量濃度，單位為納克每毫升（ng/mL）。.3外標(biāo)-工作曲線法在系列濃度的毒（藥）物血液或尿液質(zhì)控樣品中，以毒（藥）物定量離子對的峰面積（Y）為縱坐標(biāo)、毒（藥）物質(zhì)量濃度（C）為橫坐標(biāo)進(jìn)行線性回歸，得線性方程。

根據(jù)待測樣品中毒（藥）物定量離子對峰面積，按公式（3）計算出待測樣品中毒（藥）物的質(zhì)量濃度。 ………………（3）式中：C??待測樣品中毒（藥）物質(zhì)量濃度，單位為納克每毫升(ng/mL)；Y??待測樣品中毒（藥）物的峰面積；a??線性方程的截距；b??線性方程的斜率。.4外標(biāo)-單點校正法根據(jù)待測樣品及添加樣品中毒（藥）物定量離子對峰面積，按公式（4）計算出待測樣品中毒（藥）物的質(zhì)量濃度。 ………………（4）式中：C??待測樣品中毒（藥）物質(zhì)量濃度，單位為納克每毫升(ng/mL)；A??待測樣品中毒（藥）物的峰面積；A′??添加樣品中毒（藥）物的峰面積；c??添加樣品中毒（藥）物的質(zhì)量濃度，單位為納克每毫升(ng/mL)。平行試驗待測樣品同時平行測定兩份，雙樣相對相差按公式（5）計算：|C1-C2|RD（%）=100………………（5）式中：RD??相對相差；C1、C2??兩份待測樣品平行定量測定的質(zhì)量濃度；C??兩份待測樣品平行定量測定質(zhì)量濃度的平均值。6.2.4空白試驗用空白血液或尿液進(jìn)行空白試驗。7結(jié)果評價7.1定性結(jié)果評價7.1.1陰性結(jié)果評價如果待測樣品中僅檢出內(nèi)標(biāo)地西泮-d5和SKF525A，未檢出附錄A中238種毒（藥）物成分，則陰性結(jié)果可靠；如果待測樣品中未檢出內(nèi)標(biāo)，則陰性結(jié)果不可靠。7.1.2陽性結(jié)果評價如果待測樣品中檢出附錄A中毒（藥）物成分且空白樣品無干擾，則陽性結(jié)果可靠；如果待測樣品中檢出毒（藥）物成分且空白樣品亦呈陽性，則陽性結(jié)果不可靠。7.2定量結(jié)果評價平行試驗中兩份檢材的雙樣相對相差不得超過20%（腐敗檢材不得超過30%），結(jié)果按兩份檢材濃度的平均值計算，否則需要重新測定。8方法檢出限本技術(shù)規(guī)范血液中238種毒（藥）物成分的最低檢出限見附錄A。附錄A（資料性附錄）表238種毒（藥）物的LC-MS/MS分析資料目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)苯丙胺amphetamine136.1/119.1136.1/91.14020/166.71甲胺磷methamidophos142.1/94142.1/112.16020/171.7420甲基苯丙胺methamphetamine150.1/119.1150.1/91.13016/268.031苯丁胺phentermine150/91.1150/133.32027/138.051苯丙醇胺phenylpropanolamine152.1/134.3152.1/117.24016/245.1520金剛烷胺amantadine152.2/135.340246.971對乙酰氨基酚acetaminophenol152.3/110.2152.3/935021/311.5610尼古丁nicotine163.2/130.2163.2/117.13030/365.791滅多威methomyl163.2/88.030201.720甲卡西酮methcathinone164.0/146.0164.0/130.06010/345.71速滅威metolcarb166.1/109.1166.1/81.15019/312.261麻黃堿ephedrine166.1/148.1166.1/133.14018/266.091苯佐卡因benzocaine166.3/138.2166.3/120.16016/232.0920加巴噴丁gabapentin172.2/154.2172.2/137.36018/212.1620可鐵寧cotinine177.2/101.2177.2/80.23011/321.951尼可剎米nikethamide179.3/108.1179.3/72.16526/302.0913,4-亞甲基二氧基苯丙胺MDA180.1/163.1180.1/135.14015/186.481美西律mexiletine180.2/58.2180.2/163.35022/209.071乙酰甲胺磷acephate184/143.1184/125.15512/241.610愛康寧ecognine186.2/168.3186.2/82.25725/381.710安替比林antipyrine189.0/56.0189.0/77.06027/371.9620異丙威isoprocarb194.1/137.2194.1/1525513/122.4811-(3,4-亞甲二氧基苯)-2-丁胺BDB194.2/135.3194.2/177.25019/137.7613,4-亞甲基二氧基甲基苯丙胺MDMA194.2/163.4194.2/135.33518/297.761咖啡因caffeine195.2/138.2195.2/1105029/321.831愛康寧甲酯ecognineester200.2/182.2200.2/82.25225/325.0510甲萘威carbaryl202.1/145.2202.1/117.15014/352.431乙胺丁醇ethambutol205.2/116.1205.2/1496021/128.6810異丙隆isoproturon207.1/72207.1/165.16036/212.2810N-甲基-1-(3,4-亞甲二氧基苯)-2-丁胺MBDB208.3/177208.3/135.35015/288.8513,4-亞甲二氧基-N-乙基-苯丙胺MDEA208.4/163.1208.4/133.27119/238.51氧樂果omethoate214/155.1214/183.15022/151.5710莠去津atrazine216.2/174216.2/95.87525/332.1110目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)敵稗propanil218.0/162.3218.0/127.06021/372.8420眠爾通meprobamate219.2/158.2219.2/975012/191.781撲米酮primidone219.2/162.3219.2/119.25517/241.76203,4-亞甲基二氧基丙基苯丙胺MDPR222.2/163.3222.2/135.35019/2910.541克百威carbofuran222.2/165.2222.2/1235017/342.261敵敵畏dichlorvos223.1/127.1223.1/109.16023/242.151久效磷monocrotophos224.1/127.1224.1/193.15020/111.731去甲氯胺酮norketamine224.1/207.1224.1/125.14019/3241特布他林terbutaline226.1/152.1226.1/170.26023/163.9920\o""阿米洛利amiloride230.1/171230.1/212.46024/204.1210樂果dimethoate230/199230/171.145131.821異丁司特ibudilast231.1/161.5231.1/189.36025/263.1920異丙安替比林isopropylantipyrine231.1/189.1231.1/2019028/322.1510萘普生naproxen231.2/185.4231.2/170.36020/352.5620可樂定clonidine232.1/162.3232.1/215.26048/343.1920芬氟拉明fenflutamine232.2/159.3232.2/187.32032/2013.641氨基比林aminophenazone232.3/111.2232.3/98.15021/252.4210去甲哌替啶normeperidine234.2/160.3234.2/91.17523/6013.671利多卡因lidocaine235.2/86.3235.2/101.23528/149.041普魯卡因procaine237.2/100.2237.2/164.45022/237.0520卡馬西平carbamazepine237.3/194.3237.3/192.36026/321.761氯胺酮ketamine238.1/179.1238.1/125.14025/407.481沙丁胺醇salbutamol240.1/148.2240.1/222.25026/174.0220滅線磷mocap243.2/131243.2/173.05026/202.5920苯環(huán)利定phencyclidine244.2/86.0244.2/159.34017/195.5920哌替啶meperidine248.3/220.3248.3/174.15030/2810.9217-氨基硝西泮7-aminonitrazepam252.2/121.1252.2/146.28037/381.8410奧卡西平oxcarbazepine253.0/235.9253.0/208.17019/201.781西米替丁cimetidine253.2/159.370203.2810三氨蝶啶triamterene254.0/237254.0/1046027/374.0310奈福泮nefopam254.1/181.3254.1/166.36027/3811.5820拉莫三嗪lamotrigine256.1/211.2256.1/145.15035/533.371苯海拉明diphenhydramine256.2/167.2256.2/165.23017/5415.51敵百蟲trichlorfon259.3/223259.3/127.16016/231.51普萘洛爾propranolol260.1/116.1260.1/183.2602511.5910卡立普多carisoprodol261.3/200.2261.3/97.15023/151.510甲拌磷phorate261/75.1261/244.34017/104.1110目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)甲基對硫磷parathion-methyl264.1/125264.1/2326030/219.7520噻氯匹定ticlopidine264.1/125264.1/239.16044/249.7320去甲替林nortriptyline264.2/233.1264.2/191.35020/321620曲馬多tramadol264.2/58264.2/246.25037/169.741丁卡因tetracaine265.2/176.2265.2/220.45021/2511.9920米氮平mirtazapine266.1/195.1266.1/208.88037/359.210阿替洛爾atenolol267.2/145.2267.2/190.36038/263.6120美托洛爾metoprolo268.3/116.1268.3/133.26026/357.1720乙草胺acetochlor270.1/224.1270.1/1486013/303.1620甲草胺alachlor270.2/238.3270.2/162.36016/273.0920硫線磷cadusafos271.1/159.0271.1/215.06018/133.4520去甲西泮nordiazepam271.2/140.2271.2/208.17036/362.3210右美沙芬dextromethorphan272.3/147.2272.3/213.36042/3714.671布桂嗪bucinnazine273.2/117.1273.2/155.26025/205.810氯苯那敏chlorpheniramine275.2/230.1275.2/167.15022/5312.471羅哌卡因ropivacaine275.3/126.2275.3/84.26031/5811.3910環(huán)苯扎林cyclobenzaprine276.3/216.3276.3/2315034/2518.8820克侖特羅clenbuterol277.2/203.1277.2/259.16023/168.831殺螟松fenitrothion278.1/124.9278.1/246.27630/252.1610馬普替林maprotiline278.1/250.2278.1/219.26026/3415.6110阿米替林amitripthyline278.2/191.3278.2/233.36035/3020.28102-亞乙基-1,5-二甲基-3,3-二苯基吡咯烷EDDP278.2/234.3278.2/249.37041/332910文拉法辛venlafaxine278.3/58.1278.3/259.94040/1711.2810倍硫磷fenthion279.3/247.0279.3/169.05023/233.7420多塞平doxepin280.3/107.2280.3/220.25031/3615.641丙咪嗪imipramine281.3/86.2281.3/208.25024/3519.071硝西泮nitrazepam282.2/236.2282.2/180.27032/522.1410酚妥拉明phentolamine282/212.3282/239.56020/159.26207-氨基氟硝西泮7-aminoflunitrazepam284.2/135.2284.2/226.28039/411.961地西泮diazepam285.1/193.3285.1/154.18045/362.771異丙嗪promethazine285.2/86.1285.2/198.15525/3117.231嗎啡morphine286.1/201.2286.1/165.38036/563.9717-氨基氯硝西泮7-aminoclonazepam286.1/222.2286.1/250.16034/251.611氫嗎啡酮hydromorphone286.2/185.3286.2/199.18540/404.5110地莫西泮demoxepam287.1/269.3287.1/180.27038/321.8710奧沙西泮oxazepam287.2/241.2287.2/269.35031/212.0210加蘭他敏galanthamine288.1/213.2288.1/2316032/245.0610目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)特丁硫磷terbufos289.2/103289.2/2335014/105.420N-去烴氟西泮desalkylflurazepam289.2/140.2289.2/226.16037/382.120布比卡因bupivacaine289.3/140.2289.3/84.16029/5113.710異稻瘟凈iprobenfos289/91.1289/205.16066/143.061苯甲酰愛康寧benzoylecognine290.2/168.3290.2/105.27026/432.1510阿托品atropine290.3/124.1290.3/93.18534/446.21對硫磷parathion292.1/236292.1/2646021/153.8920美利曲辛melitracen292.3/247.2292.3/232.26026/3424.3720昂丹司瓊ondansetron294.2/170.3294.2/184.360379.9220艾司唑侖estazolam295.2/267.3295.2/205.27034/532.410辛可尼丁cinchonidine295.3/81.2295.3/168.36042/397.6420尼美西泮nimetazepam296.1/250.2296.1/222.17036/382.471去甲氟西汀norfluoxetine296.2/134.260103.6820艾司洛爾esmolo296.3/145.2296.3/219.25034/287.4310辛硫磷phoxim299.3/77299.3/129.06046/164.3320喹硫磷quinalphos299.1/163.2299.1/243.25029/243.8110去甲奧氮平norolanzapine299.2/198.1299.2/213.17550/3713.4220可待因codeine300.2/199.2300.2/165.38040/525.161替馬西泮temazepam301.2/255.2301.2/283.17036/192.341苯海索trihexyphenidyl302.1/97.8302.1/284.16029/2419.4910雙氫可待因dihydrocodeine302.5/199.3302.5/201.26044/425.410殺撲磷methidathion303.1/145303.1/85.15015/322.951可卡因cocaine304.1/182.2304.1/150.26028/3512.931東莨菪堿scopolamine304.3/138.3304.3/156.36031/235.5520二嗪農(nóng)diazinon305.1/169.2305.1/153.16029/303.910山莨菪堿anisodamine306.2/140.3306.2/1226035/404.7310舍曲林sertraline306.2/275.1306.2/159.28017/3420.4120唑吡坦zolpidem308.1/235.1308.1/263.24053/356.211丁咯地爾buflomedil308.1/237.1308.1/140.26028/2210.5220阿普唑侖alprazolam309.1/281.1309.1/274.28033/322.851氟西汀fluoxetine310.1/43.7310.1/148.26024/1619.210美沙酮methadone310.2/265.2310.2/105.15022/3825.681地芬尼多diphenidol310.2/292310.2/128.913023/3514.2320大麻酚CBN311.2/223.2311.2/293.16029/237.0620蒂巴因thebaine312.2/58.2312.2/266.26038/248.821奧氮平olanzapine313.1/255.9313.1/84.17025/3212.441去甲氯氮平norclozapine313.4/270313.4/192.17032/559.2420目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)氟硝西泮flunitrazepam314.2/268.3314.2/239.38535/455.811乙基嗎啡ethylmorphine314.3/229.3314.3/165.48036/535.7910四氫大麻酚THC315.2/193.2315.2/259.26032/287.0320大麻二酚CBD315.2/193.2315.2/105.26032/264.6520雷尼替丁ranitidine315.3/176.2315.3/270.37023/182.9220氯硝西泮clonazepam316.2/270.1316.2/214.17536/492.161羥考酮oxycodone316.2/298.1316.2/241.18027/365.741氯普噻噸chlorprothixene316.3/271.2316.3/231.16527/3925.4520溴西泮bromazepam317.1/183.3317.1/210.26043/352.1110古柯乙烯cocaethylene318.2/196.2318.2/150.26126/3515.1120氯丙嗪chlorpramazine319.3/86.2319.3/246.26030/3424.0110稻豐散phenthoate321.1/247.2321.1/163.16015/174.0410勞拉西泮lorazepam321.1/275.1321.1/303.16030/211.991甲基毒死蜱chlorpyrifosmethyl322.1/125.0322.1/290.06628/224.17治螟磷sulfotep323.1/171.1323.1/295.26020/154.2910二甲弗林dimefline324.4/279.3324.4/163.48022/3512.220α-羥基阿普唑侖α-hydroxyalprazolam325.2/297.2325.2/279.29035/333.5310西酞普蘭citalopram325.3/109.2325.3/262.08041/2613.910咪達(dá)唑侖midazolam326.2/291.4326.2/244.26537/354.741比索洛爾bisoprolol326.3/116.2326.3/74.18025/407.9420氯氮平clozapine327.3/270.1327.3/296.37532/3311.351單乙酰嗎啡6-acetylmorphine328.1/211.3328.1/165.39036/545.351洛沙平loxapine328.2/271.2328.2/297.38030/3614.4620納洛酮naloxone328.3/310.1328.3/253.26027/374.841拉貝洛爾labetalol329.2/311.1329.2/294.38018/277.320帕羅西汀paroxetine330.3/192.3330.3/70.16028/5113.4210馬拉硫磷malathion331.1/127.1331.1/99.16018/193.321胺菊酯tetramethrin332.4/164.4332.4/135.36034/254.621咳必清carbetapentane334.4/100.1334.4/145.36033/3021.4810芬太尼fentanyl337.2/188.3337.2/105.27031/5513.861法莫替丁famotidine338.2/189.3338.2/2596027/172.820洛貝林lobeline338.2/96338.2/216.36030/4018.820罌粟堿papaverine340.1/202.2340.1/202.26037/415.861右丙氧芬dextropropoxyphene340.2/266.2340.2/324.36012/3520.1810去氯羥嗪decloxizine341.2/167.3602410.3620α-羥基咪達(dá)唑侖α-hydroxymidazolam342.0/324.2342.0/2037029/302.4310舒必利sulpiride342.1/112.2342.1/214.26035/465.320目標(biāo)物名稱母離子/子離子對(m/z)DPCE(1/2)RtLOD中文名英文名12(V)(eV)(min)(ng/mL)乙?？纱騛cetylcodeine342.2/225.2342.2/165.38535/618.041三唑侖triazolam343.2/308.2343.2/315.28036/352.711貝凡洛爾bevantolol346.3/165.3346.3/150.18029/4511.3520硝苯地平nifedipine347.3/315.2347.3/271.46012/162.3420毒死蜱chlorpyrifos350.0/198.0350.0/322.07026/175.620美洛昔康meloxicam352.1/115.1352.1/141.28025/291.3820他扎羅汀tazarotene352.2/324.2352.2/294.38035/546.3420蘿巴新raubasine353.2/144.1353.2/210.27037/2911.410羅通定rotundine356.2/192.3356.2/165.36036/3410.7420吲哚美辛indomethacin358.2/139.3358.2/174.27026/183.2520阿曲庫銨atracurium358.4/206358.4/151.28527/419.6520α-羥基三唑侖α-hydroxytriazolam359.2/331.2359.2/176.18038/372.011尼群地平nitrendipine361.3/315.1361.3/329.28013/202.920伏殺磷phosaline370.1/184.1370.1/324.17020/184.491海洛因heroin370.2/268.2370.2/1659038/607.621曲唑酮trazodone372.2/176.2372.2/148.36034/508.251羥嗪hydroxyzine375.2/201.1602613.4820氟哌啶醇haloperidol376.2/165.4376.2/358.26033/2815.241氨溴索ambroxol379.1/264.1379.1/116.28022/246.3620賽利洛爾celiprolol380.3/251.2380.3/307.28031/256.3320甲磺隆metsulfuron-methyl382.1/167.6382.1/350.18019/161.6620哌唑嗪prazosin384.2/247.2384.2/138.26039/439.1820喹硫平quetiapine384.4/253.1384.4/2215435/539.2220乙硫磷ethion385.1/199.0385.1/143.06013/335.8120丁螺環(huán)酮buspirone386.5/121.9386.5/222.210042/399.5520舒芬太尼sufentanil387.1/238.1387.1/355.35027/2618.2220氟西泮flurazepam388.2/315.2388.2/288.16532/3310.1310尼索地平nisoldipine389.1/344.2389.1/357.1