Hotline:400-820-3792Inhibitors ? ScreeningLibraries ? Proteinswww.MedChemE2,5-DimethylcyclohexanolCat.No.:HY-W160358CASNo.:3809-32-3分子式:C?H??O分子量:128.21作用靶點:SARS-CoV;VirusProtease;Fungal;Apoptosis;ReactiveOxygenSpecies(ROS);ATPSynthase;GlutathionePeroxidase;SOD;p38MAPK作用通路:Anti-infection;Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;MembraneTransporter/IonChannel;MAPK/ERKPathway儲存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 2,5-Dimethylcyclohexanol是一種揮發(fā)性有機化合物，屬于脂肪酸，可從Amphorasp.中分離得到。2,5-Dimethylcyclohexanol具有顯著的抗腫瘤和抗病毒活性，可抑制SARS-CoV-2Mpro。2,5-Dimethylcyclohexanol還對Pseudogymnoascusdestructans具有抗真菌活性。2,5-Dimethylcyclohexanol破壞細胞壁和細胞膜的完整性，擾亂能量代謝，增加ROS,ATP,Superoxideanion和GSH的水平，并降低CAT和SOD的活性。2,5-Dimethylcyclohexanol還會改變毒力核糖體基因的表達，并破壞MAPK信號通路，從而誘導真菌細胞凋亡(apoptosis)[1][2][3]。REFERENCESKhumaidiA,etal.FattyacidprofileandinsilicopharmacologicalstudyofdiatomAmphorasp[J].Aquaculture,Aquarium,Conservation&Legislation,2020,13(4):2050-2060.HuangZ,etal.MechanismsofvolatileorganiccompoundsfrombatcaveenvironmentsagainstPseudogymnoascusdestructansinvitro.ApplEnvironMicrobiol.2025Nov13:e0118725.ShehzadiS,etal.AntiviralCOVID-19proteinandmoleculardocking:InsilicocharacterizationofvariousantiviralcompoundsextractedfromArisaemajacquemontiiBlume.FrontPublicHealth.2022Sep23;10:964741.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>