第1題【SingleChoice】TheprincipleofEnglishnamesfordrugsinChinesePharmacopoeiafollows()formulatedbytheWorldHealthOrganization.AChPBCADNCINNDBNFcorrect第2題【SingleChoice】Thecontentofpharmaceuticalpreparationsisexpressedas().AWeightpercentageBMolarpercentagecontentCVolumepercentageDLabeledamountpercentagecontentcorrect第3題【SingleChoice】Accordingtotheprovisionsofdrugqualitystandards,evaluatingthequalityofadruguses().AIdentification,inspection,qualitydeterminationBBioavailabilityCPhysicalpropertiesDPharmacologicaleffectscorrect第4題【MultipleChoice】Thecharacteristicsitemofdrugqualitystandardsmainlydescribethe()ofdrugs.AAppearance,odorandtasteBSolubilityCCategoryDPhysicalconstantsEDosageformcorrect正確答案：ABD第5題【MultipleChoice】Thephysicalconstantsincludedinthedrugqualitystandardare()AAbsorptionwavelengthBRelativedensity,distillationrange,meltingpoint,freezingpointCSpecificrotation,refractiveindex,viscosity,absorptioncoefficient,iodinevalueDSaponificationvalue,acidvalueEChromatographyretentiontimecorrect正確答案：BCD第6題【MultipleChoice】Thedrugqualitystandardis()ATechnicalregulationsondrugqualityspecificationsandinspectionmethodsBLegalbasisfollowedbydepartmentsengagedinpharmaceuticalproductionandinspectionCThelegalbasisfollowedbythedrugsupplyandusedepartmentsDLegalbasisfollowedbydrugsupervisionandadministrationdepartmentsatalllevelsEContentsthatmustbeincludedinthedruginstructionscorrect正確答案：ABCD第7題【MultipleChoice】Inthefollowingmethods,()canbeusedtoidentifydrugs.AChemicalmethodsBSpectrophotometryCChromatographyDBiologicalmethodsENonaqueoustitrationcorrect正確答案：ABCD第1題【SingleChoice】ThefullnameforICHis()AImportdrugregistrationstandardsBEuropeanPharmacopoeiaCUnitedStatesPharmacopoeia-NationalFormularyDInternationalConferenceonHarmonizationofTechnicalRequirementsforRegistrationofPharmaceuticalsforHumanUsecorrect第2題【SingleChoice】InChinesePharmacopoeia,thegeneralanalysisanddeterminationmethodsarecontainedin()AVolumeIBVolumeIICVolumeIIIDVolumeIVESupplementcorrect第3題【SingleChoice】RegardingtheChinesePharmacopoeia,themostappropriatestatementis()AAbookaboutdruganalysisBAbookcontainingallmedicinesproductedinChinaCNationallegaltechnicalstandardsforsupervisionandmanagementofdrugqualityDAdictionaryaboutdrugsETechnicalspecificationsonChineseherbalmedicinesandChinesepatentmedcines第4題【SingleChoice】ThecontentincludedintheUSNationalFormularyis()AUnitedStatesPharmacopoeiaBStandardsforfoodsupplementsCStandardsforpharmaceuticalexcipientsDStandardsforpharmaceuticalpreparationscorrect第5題【MultipleChoice】ThecontentcontainedinVolumeIVoftheChinesePharmacopoeia2015editionincludes()AChineseherbalmedicinesandprescriptionsBStandardsforchemicalmedicinesCGeneralnoticesandgeneralchaptersDStandardsforbiologicalproductsEStandardsformedicinalexcipientscorrect正確答案：CEDrugQualityControl第1題【SingleChoice】Thereareatotalof36piecesrawmaterialsenteringafactory,andthenumberofrandomsamplesshouldbe()A5piecesB6piecesC7piecesD36pieces第2題【SingleChoice】Thebasicsequenceofdruginspectionworkis()Aretainsamples→inspection→sampling→reportBinspection→sampling→retainingsample→reportCsampling→inspection→report→sampleretentionDsampling→inspection→sampleretention→report第3題【MultipleChoice】Therequirementsfordruginspectionsamplingare()AScientificalnessBAuthenticityCRepresentativenessDRigorism正確答案：BCADrugQualityStandardAndQualityControl第1題【SingleChoice】"Precisionweighing"in“ChinesePharmacopoeia”meansthattheweightshouldbeaccurateto()oftheweighttaken.A±10%B1%C1‰D1?Emillionth第2題【SingleChoice】"Easilysoluble"meansthat1g()ofsolutecanbedissolvedin()solvent.ALessthan1mlB1ml~10mlC10ml~30mlD100ml~1000mlE1000ml~10000ml第3題【SingleChoice】Thecoolanddarkplaceofthedrugstorageconditionsmeans()ANomorethan20℃BAvoidlight,notexceeding20℃C2℃~10℃DAvoidlight,10℃~30℃EAvoidlight,10℃~25℃第4題TheChinesePharamacopoeiastimulatesthat"totakeasampleof2.00g”meansthattheweightofthesampleshouldbe()A1~3gB1.5~2.5gC1.95~2.05gD1.995~2.005g第5題【SingleChoice】Whentheconcentrationofethanolisnotspecified,itrefersto()AAbsoluteethanolB30%(ml/ml)ethanolC75%(ml/ml)ethanolD95%(ml/ml)ethanol第6題【SingleChoice】Theroundingresultof21.55,75.148,10.05withthreesignificantdigitsreservedshallbe()A21.6、75.1、10.0B21.5、75.2、10.0C21.5、75.1、10D21.6、75.0、10.0第7題【MultipleChoice】Thecorrectdefinitionandrelevantregulationsofconstantweightare()ATheweightdifferenceofthetestproductaftertwoconsecutivedryingislessthan0.5mgBTheweightdifferenceofthetestproductaftertwoconsecutivedryingorburningislessthan0.3mgCThesecondandsubsequentweighingafterdryingtoconstantweightshallbecarriedoutafterdryingfor1hourunderspecifiedconditionsDThesecondandsubsequentweighingofdryingorburningshallbecarriedoutaftercontinuousdryingorburningfor1hourEThesecondandsubsequentweighingfromburningtoconstantweightshallbecarriedoutafter30minutesofcontinuousburning正確答案：BCE第8題【MultipleChoice】InChinesepharmacopoeia,the"1→10"symbolmarkedafterthesolutionrefersto()AThesolutionof1.0gsolidsoluteand10mlsolventBThesolutionof1.0mlliquidsoluteand10mlsolventCThesolidsoluteis1.0g,andthesolventisaddedtoformasolutionof10mlDTheliquidsoluteis1.0ml,andthesolventisaddedtoformasolutionof10mlEAsolutionmadeof1.0gsolidsoluteand10mlofwater(whennosolventisspecified)正確答案：CDTitrimetry第1題【SingleChoice】Usingchemicalanalysisandinstrumentalanalysistodeterminedrugcontentisreferredtoas()indrugqualitystandards.ApotencydeterminationBbiologicalstandardizationCcontentdeterminationDdrugcontrolEpuritytest第2題【SingleChoice】Thedeterminationofdrugcontentbybiologicalorenzymaticchemicalmethodsiscalled().ApotencydeterminationBbiologicalstandardizationCcontentdeterminationDdrugcontrolEpuritytest第3題【SingleChoice】Titrateis()foreach1mloftitrantatthespecifiedconcentration.AthemolenumberofthedrugmeasuredBthemassofthedrugmeasuredCthemolenumberofthestandardsubstanceDthemassofthestandardsubstanceEthemolarratiobetweenreactants第4題【SingleChoice】Residualtitrationusuallyrequires().AcalibrationofstandardtitrantconcentrationBcalibrationofexpansioncoefficientofstandardtitrantCreferenceexperimentcorrectionDcontrolexperimentcorrectionEblanktestcorrection正確答案：E第5題【SingleChoice】Inthefollowingstatementsofvolumetricanalysisusedforcontentdetermination,theincorrectoneis().AsimpleoperationBaccurateresultsCgooddurabilityDhighspecificityEbeingmainlyusedforthedeterminationofchemicalbulkdrugs第6題【SingleChoice】Accordingtopharmacopoeia,thepreciselycalibratedtitrant(suchashydrochloricacidanditsconcentration)iscorrectlyexpressedas()AHydrochloricacidtitrant(0.1520M)BHydrochloricacidtitrant(0.1520mol/L)CHydrochloricacidtitrant(0.1520M/L)D0.1520MHydrochloricacidtitrantE0.1520mol/LHydrochloricacidtitrant第7題【SingleChoice】Involumetricanalysis,theburettereadingcanbeestimatedtobe±0.02ml.Inordertoensuretheerrorofanalysisresultsnotexceed0.1%,thevolumeoftitrantshouldbe().A10mlB15~20mlCabout15mlD>20mlE<20ml第8題【SingleChoice】Thecontentwasdeterminedbydirecttitration.IfthemeasuredamountofthesampleisW,theconsumptionvolumeofthetitrantisV,thetiterisT,andtheconcentrationcorrectionfactorisF,thepercentageofthetesteddrugshouldbe().ABCD第9題多選題【MultipleChoice】ThemethodscommonlyusedinChinesepharmacopoeiaforthedeterminationofdrugcontentare().AchemicalanalysisBinstrumentalanalysisCbiologicalmethodsDenzymechemicalmethodEanimalmodelingexperiments正確答案：ABCDNeutralizationtitritionandnonaqueoustitrition第1題【SingleChoice】Non-aqueousacidmethodsusuallyuse()astitrantsolution,()assolvent,titrant()substance.

Asodiumhydroxide;water;highlyacidicBhydrochloricacid;water;highlybasicCperchloricacid;aceticacid;weaklybasicDsodiumhydroxide;dimethylformamide;weaklybasicEsodiummethoxide;dimethylformamide;weaklyacidic正確答案：E第2題【SingleChoice】Iodimetryisacommonlyused()method.Aacid-basetitrationBnon-aqueoustitrationCredoxtitrationDprecipitationtitrationEcomplexometrictitration第3題【SingleChoice】Non-aqueousalkalimetrycanbeusedforthedeterminationof()classofdrugs.AorganicweakacidBorganicweakbaseCweakoxidizabilityDweakreducibilityEamphotericcompound第4題【SingleChoice】()isoftenusedasthesolventinnon-aqueousalkalimetrytitration.AEthanolBPyridineCTolueneDGlacialaceticacidEPerchloricacid第5題【SingleChoice】()isoftenusedastheindicatorinnon-aqueousalkalimetrytitration.APhenolphthaleinBMethylorangeCCrystalvioletDThymolblueEPurplelitmustestsolution第6題【SingleChoice】Duringthetitrationofhydrohalonatesoforganicbases,thetitrationreactionisincompleteduetothestrongacidityofhydrohalonates.Itshouldbetitratedwithperchloricacidafteradding().AMercurynitrateBSilvernitrateCMercuricacetateandglacialaceticacidDEthanolENitrate第7題【MultipleChoice】()areoftenusedasindicatorsinnon-aqueousacidmethod.AAzovioletBMethylorangeCCrystalvioletDThymolblueEBromophenolblue正確答案：ADE第8題【MultipleChoice】Whentitratingaspirin,neutralethanolisusedassolventbecause().Anon-aqueoustitrationdoesnotpermittheuseofwaterBitcanpreventhydrolysisoftheesterbondsduringtitrationCcommercialethanolwhichcanbeusedaftertheneutralizationofsodiumhydroxideshowsweakacidityinphenolphthaleinDaspirinismoresolubleinethanolEitcanincreasetheapparentacidstrengthofaspirin正確答案：BC第9題【MultipleChoice】Acidbasetitrationcommonlyusedtitrantsolutionsinclude().AsodiumchlorideBsodiumhydroxideCsilvernitrateDiodineliquidEhydrochlorideaicd正確答案：BEUltravioletVisibleSpectrophotometry第1題【SingleChoice】ThebasisfortheuseofUV-Visspectrophotometryinthequantitativedeterminationofdrugsis().AArrheniusformulaBAvogadro'slawCPauliprincipleDLamberbeer'slaw第2題【SingleChoice】ThewavelengthrangeintheUV-Visregionis().A4000-400nmB40-400nmC200-760nmD200-400nm第3題【SingleChoice】UV-Visspectrophotometryischaracterizedby().AhighsensitivityBstrongspecificityCbeingnoteasilydisturbedbyimpuritiesDbeingsuitableforvolatileandnon-volatilecomponents第4題【SingleChoice】WhenthereisnostrongabsorptionofthetestproductinUV-Visregion,chromogenicagentcanbeaddedandthecontentcanbedeterminedby().AinfraredspectroscopyBthermalanalysisCprincipalcomponentdilutioncontrolmethodwithcorrectionfactorDcomputationalspectrophotometryEcolorimetricmethod正確答案：E第5題【SingleChoice】ThebasicstructureofUV-Visspectrophotometeris().Amonochromator→lightsource→absorptionpool→detector→datarecordingandprocessingBmonochromator→lightsource→detector→absorptionpool→datarecordingandprocessingClightsource→monochromator→absorptionpool→detector→datarecordingandprocessingDlightsource→monochromator→detector→absorptionpool→datarecordingandprocessing第6題SingleChoice】WhenthecontentisdeterminedbyUV-Visspectrophotometry,theabsorbanceshouldbecontrolledwithintherangeof()A0.1~1.0B0.2~0.5C0.3~0.7D1.0~2.0第7題【MultipleChoice】ThemainmethodsforcontentdeterminationbyUV-Visspectrophotometryare().AcomparisonofreferencematerialsBabsorptioncoefficientmethodCprincipalcomponentdilutioncontrolmethodwithcorrectionfactorDcomputationalspectrophotometryEcolorimetricmethod正確答案：ABDE第8題【MultipleChoice】ApplicationsofUV-Visspectrophotometryindruganalysisinclude().AcrystalanalysisBidentificationCimpuritycheckDInvivodruganalysisEcontentdetermination正確答案：BCE第9題【MultipleChoice】ThecommonlyusedlightsourcesintheultravioletregionofUV-Visspectrometeris().AdeuteriumlampBhydrogenlampCtungstenlampDhalogentungstenlampEmercurylamp正確答案：AB第10題【MultipleChoice】Quartzabsorptionpoolissuitablefor().AfarinfraredregionBnearinfraredregionCvisibleregionDmid-InfraredregionEultravioletregion正確答案：CEHigh-performanceliquidchromatographyandGaschromatography第1題【SingleChoice】Inreversephasechromatography,theorderofpeakwithlargepolaritysubstancesandsmallpolaritysubstancesis().AtheonewithhighpolaritygoesoutfirstBtheonewithsmallpolaritygoesoutfirstCtheygooutatthesametimeDtheorderisdifferentaccordingtothesituation第2題【SingleChoice】Themostcommonlyusedstationaryphaseforreversed-phasechromatographyis().AC8BC18CsilicagelDaminobondingphase第3題【SingleChoice】Unlessotherwisespecified,theresolutionshallbe().Agreaterthan2.0Bbetween0.5and1.5Cnotlessthan1Dgreaterthan1.5第4題【SingleChoice】Unlessotherwisespecified,thetrailingfactorshallbe().Abetween0.5and1.5Bgreaterthan1.5Cbetween0.95and1.05Dlessthan2.0第5題【SingleChoice】Repeatabilityofapplicabilitytestforchromatographicsystemrequirestherelativestandarddeviationofthemeasuredpeakareaofcontinuoussampleinjectionshallbe().Anotlessthan2.0%Bnotlessthan1.5%Cnotgreaterthan1.5%Dnotgreaterthan2.0%第6題【SingleChoice】Whenheadspacesamplingisusedingaschromatography,thetestproductandthecontrolproductarenotinthesamematrix,buttheeffectofmatrixeffectcanbeeliminatedbyusing().AexternalstandardmethodBinternalstandardmethodCstandardadditionmethodDonepointexternalstandardmethodEstandardcurvemethod第7題【SingleChoice】Determinationofresidualsolventindrugsisusuallyperformedby().AliquidchromatographyBfluorescenceCultravioletspectrophotometryDinfraredspectrophotometryEgaschromatography正確答案：E第8題【MultipleChoice】Applicabilitytestsofchromatographicsysteminclude().AtheoreticalplatenumberBresolutionCrepeatabilityDtailfactorEcorrectionfactor正確答案：ABCD第9題【MultipleChoice】Detectorsofliquidchromatographyinclude().AflameionizationdetectorBfluorescencedetectorCelectroncapturedetectorDUVdetectorEdifferentialrefractivedetector正確答案：BDE第10題【MultipleChoice】Detectorsofgaschromatographyinclude().AflameionizationdetectorBfluorescencedetectorCelectroncapturedetectorDUVdetectorEdifferentialrefractivedetector正確答案：ACAnalyticalmethodvalidation第1題【SingleChoice】Thedegreetowhichthemeasuredresultsareclosetothetrueorreferencevaluesiscalled().AprecisionBaccuracyClimitsofdetectionDspecificityEdurability第2題【SingleChoice】Underspecifiedtestconditions,thedegreeofproximitybetweentheresultsofthesamehomogeneoussamplemeasuredbymultiplesamplesiscalled().AprecisionBaccuracyClimitsofdetectionDspecificityEdurability第3題【SingleChoice】Inthecasethatothercomponents(suchasimpurities,degradationproducts,excipients,etc.)mayexist,theanalyticalmethodcanaccuratelymeasurethecharacteristicsofthecomponentundertest,whichiscalled().AprecisionBaccuracyClimitsofdetectionDspecificityEdurability第4題【SingleChoice】Whenthereisasmallchangeinthemeasurementcondition,thetoleranceofthemeasurementresultnotaffectedbythechangeiscalled().AprecisionBaccuracyClimitsofdetectionDspecificityEdurability正確答案：E第5題【SingleChoice】Accuracyisgenerallyexpressedas().Asignal-to-noiseratioBrelativestandarddeviationCTherecoveryrateDlinearequationEstandarddeviation第6題【SingleChoice】Detectionlimitsaregenerallydeterminedaccordingto()Asignal-to-noiseratio10:1BrelativestandarddeviationCrecoveryrateDcorrelationcoefficientEsignal-to-noiseratio3:1正確答案：E第7題【SingleChoice】()canreflectwhetherthelinearrelationshipbetweentwovariablesisgood.Asignal-to-noiseratioBrelativestandarddeviationCrecoveryrateDcorrelationcoefficientEcorrectionfactor第8題【MultipleChoice】Precisionisusuallyexpressedas().Asignal-to-noiseratioBrelativestandarddeviationCrecoveryrateDlinearequationEstandarddeviation正確答案：BE第9題【MultipleChoice】When(),analyticalmethodvalidationisrequired.AestablishingdrugstandardsBdrugproductionprocesschangesCcompositionofpreparationchangesDrevisingtheoriginalanalysismethodEdeterminingstability正確答案：ABCD第10題【MultipleChoice】Verificationsofprecisioninclude().ArepeatabilityBintermediateprecisionCreproducibilityDrecoveryrateEstabilityofsolution正確答案：ABCIntroductionofbiologicalsampleanalysis第1題【SingleChoice】Whichofthefollowingisnotafeatureofinvivosamples().

ALesssamplingBLowconcentrationtobemeasuredCManyinterferingsubstancesDOftenrequireslowtemperaturestorageEeasytoobtainrepeatedly正確答案：E第2題【SingleChoice】Immunoassayismostlyusedforthedetectionof().

ADrugsmallmoleculeBBiomacromoleculessuchasproteinsandpeptidesCCholesterolDMetalionESulfur-containingdrugs第3題【SingleChoice】Microbiologicalmethodscanbeusedfor()invivoanalysisofdrugs.ACalmsleepBCardiovascularCAntibioticDHypoglycemicEAnti-tumor第4題【MultipleChoice】Invivodruganalysisisaquantitativeanalysisof()inin-vivosamples.

ADrugBRelatedsubstancesCUnknownimpuritiesDMetabolitesEEndogenoussubstances正確答案：ADE第5題【MultipleChoice】Invivodruganalysisisanimportantmeansof().AIndividualizedmedicationBPharmacokineticresearchCPharmacoeconomicresearchDTreatmentdrugtestEGenesequencing正確答案：ABD第6題【MultipleChoice】()isthemainsampleforinvivodruganalysis.AHairBBloodCUrineDSalivaEStool正確答案：ABCDE第7題【MultipleChoice】()arecharacteristicsofinvivodruganalysis.

ASamplesusuallyneedtogothroughcomplicatedpretreatmentBHighanalyticalsensitivityrequiredCTheanalysismethodrequireshighspecificityDShortanalysistimeELargeanalysisworkload正確答案：ABCE第8題【MultipleChoice】Commonlyusedanalyticalmethodsforinvivodruganalysisinclude().

AChromatographyBImmunoassayCBiologicalanalysisDTitrimetricanalysisEGravimetricmethod正確答案：ABCPreparationandstorageofbiologicalsamples第1題【SingleChoice】Inthefollowingbiologicalsamples,()arecommonlyusedforthedeterminationofdrugmetabolitesinvivo.

AWholebloodBUrineCSalivaDMuscleEFat第2題【SingleChoice】Inplasmasamplepreparation,()arecommonlyusedanticoagulants.

AHeparinBSodiumchlorideCGlucoseDTrichloroaceticacidESodiumhydroxide第3題【SingleChoice】Ifyouneedtospecificallydeterminetheconcentrationofdrugsevenlydistributedinsideandoutsidethebloodcells,()sampleshouldbeused.

AWholebloodBPlasmaCSerumDBloodcells第4題【SingleChoice】Whencryopreserving(),afterthawing,itisnecessarytomixthesalivainthecontainerthoroughlybeforeuse,otherwisethemeasurementresultwillbeinerror.AHairBBloodCSalivaDUrineEOrganization第5題【SingleChoice】Inbothanimaltestsofdrugsandclinicaldeathscausedbyoverdosing,thedistributionofdrugsin()canprovideimportantinformationfortheinvivokineticsofdrugs.

AHairBBloodCSalivaDUrineEOrganization正確答案：E第6題【MultipleChoice】Invivosamplesinclude().

AHairBBloodCSalivaDUrineEOrganization正確答案：ABCDE第7題【MultipleChoice】Bloodconcentrationtest,unlessotherwisespecified,usuallyrefersto()drugconcentrationdetermination.AWholebloodBPlasmaCSerumDBloodcells正確答案：BC第8題【MultipleChoice】Ifurinecannotbemeasuredimmediatelyaftercollection,cryopreservationorcoldpreservationafteraddingpreservativesisrequired.Commonlyusedpreservativesare().AXyleneBChloroformCMethanolDAceticacidEHydrochloricacid正確答案：ABDEPretreatment-Proteinprecipitationandliquid-liquidExtraction第1題【SingleChoice】Inthesolventprecipitationmethod,thevolumeratioofthedrugcontainingplasmaorserumtothesolventisusually().A1:3B1:1C1:0.6D1:0.5第2題【SingleChoice】Whenprecipitatingproteinwithstrongacid,thevolumeratioofdrug-containingplasmaorserumtosolventisusually().A1:3B1:1C1:0.6D1:0.5第3題【SingleChoice】Intheproteinprecipitationmethod,()cangetnear-neutralsupernatant.AOrganicsolventprecipitationmethod.BNeutralsaltingoutmethodCStrongacidprecipitationmethodDAddingheavymetalion第4題【SingleChoice】Thevolumeratiooforganicphasetoaqueousphase(invivosample)inliquid-liquidextractionmethodisgenerally().

A1:1~1:5B1:3~1:5C1:1~5:1D10:1~5:1第5題【MultipleChoice】Pre-treatmentofbiologicalsamplesisrequiredbecause().

ALowconcentrationofanalyteinbiologicalsamplesBThecompositioniscomplexandthereismuchinterferenceCThedrugexistsinvariousformsinthebodyDTheproteininterfereswiththedeterminationELargemeasurementworkload正確答案：ABCD第6題【MultipleChoice】Themethodsforremovingproteinsfrombiologicalsamplesare().

AAddingneutralsaltBAddingstrongacidCAddinganorganicsolventthatismisciblewithwaterDThermalcoagulation正確答案：ABCD第7題【MultipleChoice】Instrongacidprecipitationmethod,commonlyusedstrongacidsare().

APhosphoricacidBTrichloroaceticacidCPerchloricacidDSulfuricacidENitricacid正確答案：BC第8題【MultipleChoice】Inthefollowingreagents,()arecommonlyusedtoprecipitateproteinsinplasmasamples.AMethanolBAcetonitrileCTrifluoroaceticacidDPhysiologicalsalineEHeparin正確答案：ABCPretreatment-Solidphaseextractionandothermethods第1題【SingleChoice】ThegeneralprocedureoflipophilicbondedphasesiliconeSPEis().

AEquilibrium→activation→sampleaddition→rinse→elutionBActivation→balance→sampleaddition→rinse→elutionCActivation→balance→rinse→sampleaddition→elutionDActivation→balance→sampleaddition→elution→rinse第2題【SingleChoice】TheenzymatichydrolysismethodofconjugatehydrolysisgenerallycontrolpHto()A6.0~7.0B6.5~7.5C4.5~5.5D7.0~8.0第3題【MultipleChoice】ThetypesofSPEfillersare().

ALipophilictypeBHydrophilictypeCIonexchangetypeDChiralchromatographictype正確答案：ABC第4題【MultipleChoice】Comparedwithusualseparationmethod,ultrafiltrationhascharacteristicsof().

ADoesnotintroducechemicalreagentsBSeparationbasedonmolecularsizeCThetestdrugislessdestructiveDCumbersomeandtime-consumingoperation正確答案：ABC第5題【MultipleChoice】Drugsortheirmetabolitescombinewithendogenoussubstancesinthebodytoproduceconjugates,amongthemthemostimportantendogenoussubstanceare().AGlycineBGlucuronicacidCSulfuricacidDAceticacidEGlutathione正確答案：BC第6題【MultipleChoice】Conjugatehydrolysismethodsinclude().

AAcidhydrolysismethodBEnzymatichydrolysismethodCAlkalinehydrolysismethodDSolvolysismethod正確答案：ABD第7題【MultipleChoice】Chemicalderivatizationissuitableforthedeterminationof()drugsormetabolites.

ALowpolarityBLowvolatilityCDetectorlowsensitivityDLargepolarityEChemicallyinert正確答案：BCD第8題【MultipleChoice】Whichfunctionalgroupsofdrugscanbechemicallyderivatized().

AR–COOHBR–OHCR–NH2DR–CH3正確答案：ABCBioanalyticalmethoddevelopmentandvalidation第1題【SingleChoice】Whichiscommonlyusedtomonitortheeffectivenessofbioanalyticalmethodsandevaluatethecompletenessandcorrectnessoftheanalyticalresultsofeachanalyticalbatchofsamples?()

AQualitycontrolsamplesBStandardsampleCSampletobetestedDInternalstandardEUnknownsample第2題【SingleChoice】Whichiscommonlyusedtoestablishastandardcurveandcalculatetheconcentrationoftheanalyteinothersamples?()

AQualitycontrolsamplesBStandardsampleCSampletobetestedDInternalstandardEUnknownsample第3題【SingleChoice】Thedetectionmethodbasedonsoftionizationmassspectrometryshouldpayattentiontotheinspectionprocess().

ADilutioneffectBDielectriceffectCResidualeffectDAmplificationeffect第4題【SingleChoice】Invivoanalysisofthestandardcurvemustincludeatleast()concentrationpointsexceptforthezeropoint.A4B5C6D7E8第5題【SingleChoice】Theregressionequationofthestandardcurveofchromatographyofinvivoanalysisrequiresthatthecorrelationcoeffcientγnotlessthan()A0.9B0.95C0.99D0.999E0.9999第6題【SingleChoice】Theextractionefficiencyoftheliquid-liquidextractionmethodisevaluatedas().

ARelativerecoveryrateBExtractionrecoveryrateCRelativestandarddeviationDDielectriceffect第7題【MultipleChoice】Inthestudyofpharmacokineticsandbioavailability,thelowerlimitofquantitationshouldsatisfie().ADeterminationofdrugconcentrationininvivosampleswith3to5eliminationhalf-livesBDeterminationofthedrugconcentrationfrom1/20to1/10ofCmaxCDeterminationofsampleswithcontentbelow5ngDDeterminationofsampleswithcontentbelow10pgES/Nratiobegreaterthan10正確答案：AB第8題【MultipleChoice】Thecontentofstabilityverificationofinvivodruganalysissamplesgenerallyincludes().

AThebiologicalsampleisplacedatroomtemperature(generally8horaccordingtotheactualsituation)BBiologicalsamplesarestoredintherefrigerator(4°Cor?20°C)andrepeatedlyfrozenandthawedfor3timesCStabilityofbiologicalsamplesfromlong-termfreezingtothecompletionoftheentireanalysisDStabilityofthesampleinjectorplacedafteranalysis(generally8-9h)EStabilityofstandardsubstancestocksolution(storedat4℃or?20℃)正確答案：ABCDE第9題【MultipleChoice】Theperformanceindicatorsofinvivodruganalysismethodsinclude().

ASpecificityBStandardcurveandquantitativerangeCLowerlimitofquantitationDPrecisionandaccuracyEDurability正確答案：ABCDOverviewofbiologicalproductanalysis第1題【SingleChoice】Whichofthefollowingisnotbiologicalproducts:()AVaccinedrugsBAntitoxinandantiserumdrugsCBloodproductsDRecombinantDNAproductsEAntibiotics正確答案：E第2題【SingleChoice】Whichofthefollowingisabiotechnologydrug:()APhenobarbitalBVitaminsCAmoxicillinDInsulinEParacetamol第3題【MultipleChoices】Biologicalproductscanbedividedintoseveralcategoriesaccordingtotheirchemicalnatureandchemicalcharacteristics:()APeptidesandproteinsBEnzymesandcoenzymesCPolysaccharidesDNucleicacidsELipids正確答案：ABCDE第4題【MultipleChoices】Whichfactorscanaffectthestabilityofbiologicalproducts:()ATemperatureBHumidityCTimeDProductionprocessEpH正確答案：ABCDE第5題【MultipleChoices】Biochemicaldrugsreferto:()ABasicsubstancesoflifeextractedfromanimals,plantsandmicroorganismsBBiological-chemicalsemi-syntheticbasicsubstancesoflifeCBasicsubstancesoflifemadewithmodernbiotechnol