1、Medicinal chemistrymedicinal or pharmaceutical chemistry is a discipline at the intersection of chemistry And pharmacology involved with designing，Synthesizingpharmaceutical chemistry is focusused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products。compou

2、nds used as medicines are overwhelding ly organic compounds including small organic moleges and bio polymers . however，In organic compoundsmedicinal chemistry is a highly interdisciplinary science combing organic chemistry with biochematimistry，computational chemistry，computational chemistryProcess

3、of drug discovery探索the first step of dru discovery invoices the identification of novel active compounds，often called hits ，Which are typically foundwhile a number of approaches toward The identification of hits exist，The most successful of techniques reliees on chemical and biological intuntushits

4、may originate also from random chemical libraries，Such as those created through combatorial chemistry or historic chemical compound colols優(yōu)化another step in dru discovery invlves further chemical modification in order to improve the biological and physical chemical properties of a given chiventhe qua

5、ntitative structure-activity relationship(QSAR)Of the pharmacophore play an important part in finding lead compounds，whichthere are many theories，The most relevent being Hans CHS analysis that invoices hammett electronic parameters，lip parameters and logp開(kāi)發(fā)the final step invoices the rendering the l

6、ead compounds suitable for use in clinical trials .this involves the optimization of the synthetic route for Bulk production，and the preparation of a suitable drug formulation。Training in medicinal chemistrymany workers in the field do not have formal training in medicinal chemistry。although sever a

7、l graduate schools and colleges of pharmacy offer formal p h . d . programs in medicinal chemistry，F(xiàn)requently the broader educationa majority of working medicinal chemists have Degrees in organic chemistry，rather than medicinal chemistry。2medicinal chemistry is a multifaceted discipline that encompm

8、asses synthetic organic chemistry，natural products chemistry，enzymogrogymedicinal chemistry is by nature an interdisciplinary science，And practioners have a strong background in organic chemistry，Coupled with both of which are traditionally associated with schools of pharmacy . some chemistry depart

9、ments also have programs in medicinal chemistryText Twoglossary of terms used in medicinal chemistry(2)(IUPAC Recommendations 1998)1，ind : abbreviation for investigation al new drug。2，intrinsic activity : intrinsic activity is the maximal stimuator y response induced by a compound in relation to that of a given reference3，thisterm has evolved with common usage。it was introducted by arins as a proportional factor between tissue response and receptor occupancy。The num Erical value of intrinsic activity(alpha)could range from unity