感染與心血管疾病一、一、文獻來源二、內(nèi)容簡介三、分析與討論四、結(jié)論與啟示一、文獻來源一、文獻來源1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS20101083922INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ20043114133IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,236924135EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014FEB13,PMID245326821、感染（INFECTION）系指由細菌、病毒、真菌、衣原體、支原體、立克次體、螺旋體、原蟲、蠕蟲等病原體所致的疾病。各類病原體可引起多種類型的感染致心血管疾病，使患者健康嚴重受損和社會負荷沉重不堪。2、感染導致心血管疾病以感染性心包炎、感染性心肌炎和感染性心內(nèi)膜炎較常見，而感染性心瓣膜病多由感染性心內(nèi)膜炎引起，感染性血管炎較為少見。3、診治在盡快留取實驗室檢查標本（如疑診感染性心內(nèi)膜炎患者至少抽3次靜脈血進行血培養(yǎng)，采血間隔30MIN1H）后，應根據(jù)循證醫(yī)學和相關(guān)指南盡早、足量、經(jīng)驗性選用抗感染藥物。二、內(nèi)容簡介二、內(nèi)容簡介三、分析與討論三、分析與討論1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS2010108392ASEVERALMECHANISMSTRIGGERTHEDISRUPTIONOFANADVANCEDCORONARYLESIONTHEDISRUPTEDSURFACEEXPOSESUNDERLYINGTHROMBOGENICMATERIALPLAQUEDISRUPTIONALONEISNOTSUCIENTFORTHEDEVELOPMENTOFANACUTECORONARYSYNDROMEBTHROMBOGENICCONDITIONSLOCALANDSYSTEMICDETERMINETHROMBUSFORMATIONCTHEOCCLUSIVENATUREOFTHETHROMBUSTOTALVSPARTIAL,THEDEGREEOFSTENOSIS,THEPRESENCEOFVASOCONSTRICTION,THECORONARYPERFUSIONPRESSURE,ANDTHEMYOCARDIALMETABOLICBALANCEDEMANDVSSUPPLYDETERMINETHEEVOLUTIONOFANACUTECORONARYSYNDROME2INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ2004311413TABLEIIEFFECTSOFINFLUENZAONTHECOAGULATIONSYSTEM3IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,23692413感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的診斷標準5EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014，13PMID24532682ENTEROCOCCUSSPPACCOUNTFOR10OFINFECTIVEENDOCARDITISIEALTHOUGHDAPTOMYCINISABACTERICIDALDRUGWITHINVITROACTIVITYAGAINSTENTEROCOCCUS,THEREISLITTLEEXPERIENCEOFITSUSEINIETHISWASARETROSPECTIVEDESCRIPTIVESTUDYCOMPARINGTHEEFCACYOFDAPTOMYCINVERSUSAMPICILLIN/CEFTRIAXONEVERSUSCONVENTIONALANTIBIOTICREGIMENSAMPICILLINORVANCOMYCINGENTAMICININEIETABLE1BASELINECHARACTERISTICSOFTHE32PATIENTSWITHENTEROCOCCALINFECTIVEENDOCARDITISDIAGNOSEDDURINGTHESTUDYPERIOD1、感染引起心血管疾病的確診比較困難，并且往往較晚，起始經(jīng)驗治療對患者預后有著重要意義。2、病毒性心肌炎以對癥支持治療為主。雖然免疫參與了病程進展，但是抑制免疫的藥物并不能改善患者的預后。3、根據(jù)ESC及BSAC指