感染與心血管疾病一、一、文獻(xiàn)來源二、內(nèi)容簡(jiǎn)介三、分析與討論四、結(jié)論與啟示一、文獻(xiàn)來源一、文獻(xiàn)來源1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS20101083922INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ20043114133IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,236924135EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014FEB13,PMID245326821、感染（INFECTION）系指由細(xì)菌、病毒、真菌、衣原體、支原體、立克次體、螺旋體、原蟲、蠕蟲等病原體所致的疾病。各類病原體可引起多種類型的感染致心血管疾病，使患者健康嚴(yán)重受損和社會(huì)負(fù)荷沉重不堪。2、感染導(dǎo)致心血管疾病以感染性心包炎、感染性心肌炎和感染性心內(nèi)膜炎較常見，而感染性心瓣膜病多由感染性心內(nèi)膜炎引起，感染性血管炎較為少見。3、診治在盡快留取實(shí)驗(yàn)室檢查標(biāo)本（如疑診感染性心內(nèi)膜炎患者至少抽3次靜脈血進(jìn)行血培養(yǎng)，采血間隔30MIN1H）后，應(yīng)根據(jù)循證醫(yī)學(xué)和相關(guān)指南盡早、足量、經(jīng)驗(yàn)性選用抗感染藥物。二、內(nèi)容簡(jiǎn)介二、內(nèi)容簡(jiǎn)介三、分析與討論三、分析與討論1ROLEOFACUTEINFECTIONINTRIGGERINGACUTECORONARYSYNDROMESLANCETINFECTDIS2010108392ASEVERALMECHANISMSTRIGGERTHEDISRUPTIONOFANADVANCEDCORONARYLESIONTHEDISRUPTEDSURFACEEXPOSESUNDERLYINGTHROMBOGENICMATERIALPLAQUEDISRUPTIONALONEISNOTSUCIENTFORTHEDEVELOPMENTOFANACUTECORONARYSYNDROMEBTHROMBOGENICCONDITIONSLOCALANDSYSTEMICDETERMINETHROMBUSFORMATIONCTHEOCCLUSIVENATUREOFTHETHROMBUSTOTALVSPARTIAL,THEDEGREEOFSTENOSIS,THEPRESENCEOFVASOCONSTRICTION,THECORONARYPERFUSIONPRESSURE,ANDTHEMYOCARDIALMETABOLICBALANCEDEMANDVSSUPPLYDETERMINETHEEVOLUTIONOFANACUTECORONARYSYNDROME2INFLUENZAANDCARDIOVASCULARDISEASEISTHEREACAUSALRELATIONSHIPTEXHEARTINSTJ2004311413TABLEIIEFFECTSOFINFLUENZAONTHECOAGULATIONSYSTEM3IMMUNOSUPPRESSIVETREATMENTFORINFLAMMATORYCARDIOMYOPATHYINTHEARTJ2005461131224GUIDELINESONTHEPREVENTION,DIAGNOSIS,ANDTREATMENTOFINFECTIVEENDOCARDITISNEWVERSION2009EUROPEANHEARTJOURNAL200930,23692413感染性心內(nèi)膜炎的臨床表現(xiàn)感染性心內(nèi)膜炎的診斷標(biāo)準(zhǔn)5EFFICACYOFDAPTOMYCININTHETREATMENTOFENTEROCOCCALENDOCARDITISA5YEARCOMPARISONWITHCONVENTIONALTHERAPYJANTIMICROBCHEMOTHER2014，13PMID24532682ENTEROCOCCUSSPPACCOUNTFOR10OFINFECTIVEENDOCARDITISIEALTHOUGHDAPTOMYCINISABACTERICIDALDRUGWITHINVITROACTIVITYAGAINSTENTEROCOCCUS,THEREISLITTLEEXPERIENCEOFITSUSEINIETHISWASARETROSPECTIVEDESCRIPTIVESTUDYCOMPARINGTHEEFCACYOFDAPTOMYCINVERSUSAMPICILLIN/CEFTRIAXONEVERSUSCONVENTIONALANTIBIOTICREGIMENSAMPICILLINORVANCOMYCINGENTAMICININEIETABLE1BASELINECHARACTERISTICSOFTHE32PATIENTSWITHENTEROCOCCALINFECTIVEENDOCARDITISDIAGNOSEDDURINGTHESTUDYPERIOD1、感染引起心血管疾病的確診比較困難，并且往往較晚，起始經(jīng)驗(yàn)治療對(duì)患者預(yù)后有著重要意義。2、病毒性心肌炎以對(duì)癥支持治療為主。雖然免疫參與了病程進(jìn)展，但是抑制免疫的藥物并不能改善患者的預(yù)后。3、根據(jù)ESC及BSAC指