1、Department of Medical Oncology, Jiangsu Province Institute of Cancer Research概述概述 FdUMP: 5-氟尿嘧啶脫氧核苷5-單磷酸鹽 FdUrd: 5-氟尿嘧啶脫氧核苷 MS:蛋氨酸合酶 MTHFR: 亞甲基四氫葉酸復(fù)原酶 THF: 四氫葉酸 TK: 胸腺嘧啶脫氧核苷激酶 TP: 胸腺啶磷酸化酶 TYMS(TS): 胸苷酸合成酶 5,10-CH2-THF: 5,10-亞甲基四氫葉酸 5-CH3-THF: 5-甲基四氫葉酸 5-FU: 5-氟尿嘧啶 DHF: 二氫葉酸; DHFR:二氫葉酸復(fù)原酶 DHFU: 二氫氟尿嘧

2、啶 DPYD: 二氫嘧啶脫氫酶 dTMP: 脫氧胸苷5-單磷酸鹽 dUMP: 脫氧尿苷5-單磷酸鹽5氟尿嘧啶代謝途徑Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy 。Br J Cancer. 2019 Sep 2;99(5):716-21. KaplanMeier survival curves for patients in relation t

3、o (a) MTHFR C677T polymorphism (log rank=0.01, p=0.92) and (b) MTHFR A1298C polymorphism (log rank=10.67, p=0.001) KaplanMeier survival curves for patients after 5-FU-based chemotherapy (n=) in relation to the MTHFR C677T genotypes (log rank=3.86, p=0.05) and MTHFR A1298C genotypes (log rank=6.82, p

4、=0.009) Association of polymorphisms MTHFR C677T and A1298C with risk of colorectal cancer, genetic and epigenetic characteristic of tumors, and response to chemotherapy . Int J Colorectal Dis. 2019 Feb;25(2):141-51 MTHFR Gene Polymorphism and Response (79 patients )MTHFR, methylenetetrahydrofolate reductase.& # : P = 0.04 Journal of Clinical Oncology, Vol 23, No 7 (March 1), 2019: pp. 5-9 Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by t