1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECloprostenol sodium saltCat. No.: HY-108415CAS No.: 55028-72-3Synonyms: ICI 80996 sodium salt分式: CHClNaO分量: 446.9作靶點(diǎn): Prostaglandin Receptor作通路: GPCR/G Protein儲存式: 4C, sealed storage, away from moisture* In solvent : -80C, 6 mon

2、ths; -20C, 1 month (sealedstorage, away from moisture)溶解性數(shù)據(jù)體外實驗 H2O : 150 mg/mL (335.65 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.2376 mL 11.1882 mL 22.3764 mL5 mM 0.4475 mL 2.2376 mL 4.4753 mL10 mM 0.2238 mL 1.1188 mL 2.2376 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇

3、合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Cloprostenol sodium salt (ICI 80996 sodium salt)種合成的、有效的前列腺素類似物，具有黃體溶解性1，為 PGF2 receptor 的激動劑 2。IC50 & Target PGF2 receptor 2體外研究Cloprostenol is a PGF2 receptor agonist 2.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemECloprostenol (0.1 M) counteract

4、s the adipogenic effects of statil, on both intracellular lipid accumulation andexpression of transcripts for proadipogenic factors C/EBP and PPAR after treatment for 6 days 2.體內(nèi)研究 Cloprostenol sodium salt (25 g) decreases plasma progesterone in pregnant rats 1.REFERENCES1. Salazar H, et al. Luteoly

5、tic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemicalobservations. Biol Reprod. 1976 May;14(4):458-72.2. Pastel E, et al. Aldose reductases influence prostaglandin F2 levels and adipocyte differentiation in male mouse and human species.Endocrinology. 2015 May;156(5):1671-84.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0