1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEHMT2-IN-1Cat. No.: HY-111778CAS No.: 2230849-55-3分式: CHNO分量: 353.42作靶點: Histone Methyltransferase作通路: Epigenetics儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 55 mg/mL (155.62 mM; Need u

2、ltrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.8295 mL 14.1475 mL 28.2949 mL5 mM 0.5659 mL 2.8295 mL 5.6590 mL10 mM 0.2829 mL 1.4147 mL 2.8295 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗 請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件

3、，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 0.92 mg/mL (2.60 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 0.92 mg/mL (2.60 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 0.92 mg/mL (2.60 mM

4、); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 EHMT2-IN-1種有效的 EHMT 抑制劑，對 EHMT1 多肽, EHMT2 多肽和細胞內(nèi) EHMT2 的 IC50 均于 100nM。于液疾病或癌癥的研究 1。IC50 & Target EHMTI PEP EHMT2 PEP EHMT2 ICW50) 50) 50)體外研究 EHMT2-IN-1 (Compound 108) potent EHMT inhibitor, with IC50s of all 1.REFERENCES1. John Emmerson Campbell, et al. Amine-substituted heterocyclic compounds as ehmt2 inhibitors and methods of use thereof.WO2018118842A1McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>