1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEKDM4D-IN-1Cat. No.: HY-101928CAS No.: 2098902-68-0分式: CHNO分量: 225.21作靶點: Histone Demethylase作通路: Epigenetics儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 6 mg/mL (26.64 mM; Need ultrasoni

2、c)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 4.4403 mL 22.2015 mL 44.4030 mL5 mM 0.8881 mL 4.4403 mL 8.8806 mL10 mM 0.4440 mL 2.2201 mL 4.4403 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 KDM4D-IN-1種新型組蛋賴氨酸去甲基化酶 4D (KDM4D) 抑制劑，IC50 為 0.410.03 M。IC50 & Target IC50:0.41

3、0.03 M (KDM4D) 1體外研究 KDM4D-IN-1 (Compound 10r) is the most potent one with an IC50 value of 0.410.03 M against KDM4D.KDM4D-IN-1 displays almost no activity against KDM2B, KDM3B, and KDM5A (IC5010 M), indicating thatKDM4D-IN-1 has a good selectivity for KDM4D against other selected KDMs 1.1/2 Master

4、of Small Molecules 您邊的抑制劑師www.MedChemEREFERENCES1. Fang Z, et al. Discovery of pyrazolo1,5-apyrimidine-3-carbonitrile derivatives as a new class of histone lysine demethylase 4D(KDM4D) inhibitors. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3201-3204.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 02