1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOrotic acidCat. No.: HY-N0157CAS No.: 65-86-1Synonyms: 6-Carboxyuracil; Vitamin B13分式: CHNO分量: 156.1作靶點(diǎn): Nucleoside Antimetabolite/Analog; Endogenous Metabolite作通路: Cell Cycle/DNA Damage; Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20

2、C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 6.4061 mL 32.0308 mL 64.0615 mL5 mM 1.2812 mL 6.4061 mL 12.8123 mL10 mM 0.6406 mL 3.2031 mL 6.4061 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備

3、液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 乳清酸（OA）是嘧啶代謝過(guò)程中的中間體。IC50 & Target Human Endogenous Metabolite戶使本產(chǎn)品發(fā)表的科研獻(xiàn)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE J Mol Med (Berl). 2019 Jun 14.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jung, E.J., K.Y. Lee, and B.H. Lee, Pr

4、oliferating effect of orotic acid through mTORC1 activation mediated by negative regulation ofAMPK in SK-Hep1 hepatocellular carcinoma cells. J Toxicol Sci, 2012. 37(4): p. 813-21.2. Manjeshwar, S., et al., The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in n

5、ormal rat liver invivo. Mol Carcinog, 1999. 24(3): p. 188-96.3. Cha, J.Y., et al., Effect of betaine on the hepatic damage from orotic acid-induced fatty liver development in rats. J Enzyme Inhib MedChem, 2011.4. Jung, E.J., et al., Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. J Lipid Res, 2011. 52(9): p.1617-25.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;