1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESuprofenCat. No.: HY-B0270CAS No.: 40828-46-4Synonyms: TN-762分式: CHOS分量: 260.31作靶點: PGE synthase作通路: Immunology/Inflammation儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (384.16

2、 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.8416 mL 19.2079 mL 38.4157 mL5 mM 0.7683 mL 3.8416 mL 7.6831 mL10 mM 0.3842 mL 1.9208 mL 3.8416 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，

3、體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (9.60 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (9.60 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制

4、劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (9.60 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Suprofen (TN-762)甾體抗炎化合物，能抑制前列腺素合成。IC50 & Target PGE synthase 1.體外研究 Suprofen (TN-762) is an NSAID. Suprofen (TN-762) is an ibuprofen-type anti-inflammatory analgesic andantipyretic

5、. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. suprofen wasclinically effective but the differential suppression of prostanoids favors 200mg which spares 6-keto PGF1a1.REFERENCES1. Yeadon, A., et al., Suprofen. An overview of long-term safety. Pharmacology, 1983. 2

6、7 Suppl 1: p. 87-94.2. Dawood, M.Y. and F.S. Khan-Dawood, Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-ketoprostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea. Prostaglandins Other Lipid Mediat, 2007. 83(1-2): p. 146-53.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40