1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEndovionCat. No.: HY-105917CAS No.: 265646-85-3Synonyms: NS3728分式: CHBrFNO分量: 495.18作靶點(diǎn): Chloride Channel作通路: Membrane Transporter/Ion Channel儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO :

2、 125 mg/mL (252.43 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.20 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (4.20 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Endovion (NS3728)種離

3、通道抑制劑 (如氯離通道)，也特異性的VRAC/VSOAC阻斷劑 1。Endovion (NS3728)還種ANO1抑制劑 2。IC50 & Target Chloride channel, VRAC/VSOAC 1.ANO1 2.REFERENCES1. Srensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-inducedexpression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3

4、 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73.2. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-5