Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEYAP/TAZinhibitor-2Cat.No.:HY-147322CASNo.:2762617-31-0分?式:C??H??F?N?O分?量:390.33作?靶點:YAP作?通路:StemCell/Wnt儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(256.19mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5619mL12.8097mL25.6193mL5mM0.5124mL2.5619mL5.1239mL10mM0.2562mL1.2810mL2.5619mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性YAP/TAZinhibitor-2?種有效的具有?服活性的TEAD-YAP/TAZ抑制劑，EC50值為3nM。YAP/TAZinhibitor-2顯?出抗增殖活性。YAP/TAZinhibitor-2顯?出抗腫瘤活性[1]。IC50&TargetEC50:3nM(TEAD-YAP/TAZ)[1]體外研究YAP/TAZinhibitor-2(compound5)(0-20000nM;24h)showsantiproliferativeactivitywithanIC50valueof1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE5.33nMinNCI-H226cells[1].體內(nèi)研究YAP/TAZinhibitor-2(0.5,2,5,50mg/kg;p.o.;dailyfor28days)showsanti-tumoractivitywithnosignificantbodyweightlossduringthetreatmentinBALB/cnudemice(NCI-H226xenograftmodel)[1].REFERENCES[1].Xu,xiaofeng,etal.Bicycliccompounds,compositionsandusethereof.WO2022037568A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-