Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEDC661Cat.No.:HY-111621CASNo.:1872387-43-3分?式:C??H??Cl?N?分?量:552.58作?靶點(diǎn):Autophagy;Autophagy;Apoptosis作?通路:Autophagy;Apoptosis儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:62.5mg/mL(113.11mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.8097mL9.0485mL18.0969mL5mM0.3619mL1.8097mL3.6194mL10mM0.1810mL0.9048mL1.8097mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(3.76mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性DC661?種有效的棕櫚酰蛋?硫酯酶1(PPT1)抑制劑，抑制?噬(autophagy)，并作為抗溶酶體劑。具有抗腫瘤活性[1]。IC50&TargetPPT1,autophagy[1]體外研究DC661(0.1and10μM)accumulatesautophagicvesiclesinmelanomacells[1].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?NatBiotechnol.2022Jul25.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].RebeccaVW,etal.PPT1PromotesTumorGrowthandIstheMolecularTargetofChloroquineDerivativesinCancer.ancerDiscov.2019Feb;9(2):220-229.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792