Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETRAP-6Cat.No.:HY-P0078CASNo.:141136-83-6Synonyms:PAR-1agonistpeptide;ThrombinReceptorActivatorPeptide6分?式:C??H??N??O?分?量:748.87Sequence:Ser-Phe-Leu-Leu-Arg-AsnSequenceShortening:SFLLRN作?靶點:ProteaseActivatedReceptor(PAR)作?通路:GPCR/GProtein儲存?式:Powder-80°C2years-20°C1yearInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗H2O:25mg/mL(33.38mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.3353mL6.6767mL13.3535mL5mM0.2671mL1.3353mL2.6707mL10mM0.1335mL0.6677mL1.3353mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性TRAP-6(PAR-1agonistpeptide)，?種多肽?段，選擇性的蛋?酶激活受體1(PAR1)激動劑。TRAP-6通過1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE凝?酶受體激活???板。TRAP-6對PAR4?活性。IC50&TargetPAR1[1]體外研究TRAP-6(0.01-10μM)triggerscalciummobilizationinXenopusoocytesheterologouslyexpressingPAR1[1].TRAP-6(0.01-10μM;30min)activateshumanplatelets[1].TRAP-6(100μM)doesnotcausetheplateletsofrabbitsorratstochangeshape,aggregate,releasegranulecontents,orformthromboxane[2].體內(nèi)研究TRAP(1mg/kg;i.v.)producesabiphasicresponseinbloodpressureininactin-anesthetizedrats[3].戶使?本產(chǎn)品發(fā)表的科研?獻?Phytomedicine.12June2022,154271.?MolMedRep.2019Jun;19(6):5291-5300.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KahnML,et,al.Protease-activatedreceptors1and4mediateactivationofhumanplateletsbythrombin.JClinInvest.1999Mar;103(6):879-87.[2].Kinlough-RathboneRL,et,al.Rabbitandratplateletsdonotrespondtothrombinreceptorpeptidesthatactivatehumanplatelets.Blood.1993Jul1;82(1):103-6.[3].ChintalaMS,et,al.Disparateeffectsofthrombinreceptoractivatingpeptideonplateletsandperipheralvasculatureinrats.EurJPharmacol.1998May22;349(2-3):237-43.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: