疏風(fēng)醒鼻法治療兒童變應(yīng)性鼻炎（風(fēng)邪犯肺型）對血清IL-35、IL-37的影響摘要：

目的：研究疏風(fēng)醒鼻法治療兒童變應(yīng)性鼻炎（風(fēng)邪犯肺型）對血清IL-35、IL-37的影響。

方法：選擇2019年10月至2020年5月在本院住院治療的40例兒童變應(yīng)性鼻炎（風(fēng)邪犯肺型）患兒作為研究對象，隨機(jī)分為治療組和對照組，每組各20例。對照組采用傳統(tǒng)的中藥、抗過敏藥物等治療方法，而治療組采用疏風(fēng)醒鼻法治療。通過觀察患兒的病情變化以及采集患者的血清樣本，比較兩組患兒治療前后血清IL-35、IL-37的水平變化。

結(jié)果：治療組治療后總有效率高于對照組（95%與75%），差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后治療組患兒的鼻炎癥狀明顯改善，呼吸道癥狀減輕，對常見的過敏原具有更好的耐受性。治療組患兒血清IL-35、IL-37水平增加明顯，并且治療后血清IL-35、IL-37水平與對照組相比有顯著升高（P＜0.05）。

結(jié)論：疏風(fēng)醒鼻法可以治療兒童變應(yīng)性鼻炎（風(fēng)邪犯肺型），能夠有效地改善患兒癥狀，并且具有調(diào)節(jié)機(jī)體免疫功能的作用，在治療過程中可以提高血清IL-35、IL-37水平。

關(guān)鍵詞：疏風(fēng)醒鼻法；兒童變應(yīng)性鼻炎；風(fēng)邪犯肺型；IL-35；IL-37

Abstract:

Objective:ToinvestigatetheeffectofShufengXingbitherapyonserumIL-35andIL-37inthetreatmentofchildrenwithallergicrhinitis(wind-heatinvadinglungtype).

Methods:Fortychildrenwithallergicrhinitis(wind-heatinvadinglungtype)whowerehospitalizedinourhospitalfromOctober2019toMay2020wereselectedastheresearchobjectsandrandomlydividedintoatreatmentgroupandacontrolgroup,with20casesineachgroup.ThecontrolgroupwastreatedwithtraditionalChinesemedicine,anti-allergicdrugs,andothertreatmentmethods,whilethetreatmentgroupwastreatedwithShufengXingbitherapy.Thechangesinthepatients'conditionwereobserved,andserumsampleswerecollectedtocomparethechangesinthelevelsofIL-35andIL-37inthetwogroupsofpatientsbeforeandaftertreatment.

Results:Thetotaleffectiverateofthetreatmentgroupwashigherthanthatofthecontrolgroupaftertreatment(95%and75%,respectively),andthedifferencewasstatisticallysignificant(P<0.05).Aftertreatment,thesymptomsofrhinitisinthetreatmentgroupweresignificantlyimproved,respiratorysymptomswerereduced,andtolerancetocommonallergenswasbetter.ThelevelsofIL-35andIL-37inthetreatmentgroupweresignificantlyincreasedaftertreatment,andthelevelsofIL-35andIL-37inthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup(P<0.05).

Conclusion:ShufengXingbitherapycaneffectivelytreatchildrenwithallergicrhinitis(wind-heatinvadinglungtype),improvetheirsymptoms,andregulatethebody'simmunefunction.Duringtreatment,thelevelsofserumIL-35andIL-37canbeincreased.

Keywords:ShufengXingbitherapy;allergicrhinitisinchildren;wind-heatinvadinglungtype;IL-35;IL-3Allergicrhinitisisacommondiseaseinchildrenthataffectstheirqualityoflife.Thetreatmentofallergicrhinitismainlyincludesdrugtherapyandimmunotherapy.ShufengXingbitherapyisatraditionalChinesemedicinetreatmentthatiseffectiveintreatingallergicrhinitis.ThecurrentstudyaimedtoevaluatetheefficacyofShufengXingbitherapyintreatingchildrenwithallergicrhinitis(wind-heatinvadinglungtype)andtoinvestigatethechangesinthelevelsofIL-35andIL-37duringtreatment.

TheresultsofthisstudyshowedthataftertreatmentwithShufengXingbitherapy,thetotaleffectiverateofclinicalsymptomswassignificantlyhigherthanthatofthecontrolgroup.Thenasalsymptomssuchasrunnynose,nasalcongestion,andsneezingweresignificantlyimprovedinthetreatmentgroupcomparedtothecontrolgroup.Additionally,theserumlevelsofIL-35andIL-37inthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup.ThismaysuggestthatShufengXingbitherapycanregulatethebody'simmunefunctionbyincreasingthelevelsoftheseanti-inflammatorycytokines.

Inconclusion,ShufengXingbitherapycanbeaneffectivetreatmentforchildrenwithallergicrhinitis(wind-heatinvadinglungtype).Thetherapycanimprovetheclinicalsymptomsandregulatetheimmunefunctionofthebody.ThelevelsofserumIL-35andIL-37canbeincreasedduringthetreatment,indicatingitspotentialmechanismofaction.FurtherstudieswithalargersamplesizeandlongertreatmentdurationareneededtoconfirmtheefficacyandsafetyofShufengXingbitherapyforallergicrhinitisinchildrenInadditiontoShufengXingbitherapy,thereareothertreatmentoptionsavailableforchildrenwithallergicrhinitis.Theseincludenasalcorticosteroids,antihistamines,decongestants,leukotrienereceptorantagonists,andimmunotherapy.

Nasalcorticosteroidsareeffectiveinreducingnasalcongestion,inflammation,andmucusproduction.Theyaresafeandwell-tolerated,butmaytakeseveraldaystostartworking.Somecommonnasalcorticosteroidsincludefluticasone,budesonide,andmometasone.

Antihistaminesaremedicationsthatblocktheeffectsofhistamine,achemicalreleasedbymastcellsduringanallergicreaction.Theycanrelievesneezing,itching,andrunnynose,butmaycausedrowsinessordrymouth.Commonantihistaminesusedinchildrenincludeloratadine,cetirizine,andfexofenadine.

Decongestantsaremedicationsthatshrinkswollenbloodvesselsinthenasalpassages,reducingcongestion.Theycanbetakenorallyorappliedtopicallyasnasalsprays,butshouldnotbeusedformorethanafewdaysduetoriskofreboundcongestion.Commondecongestantsincludepseudoephedrineandphenylephrine.

Leukotrienereceptorantagonistsaremedicationsthatblocktheeffectsofleukotrienes,substancesproducedbyimmunecellsthatpromoteinflammationandallergysymptoms.Theycanbeanalternativetoantihistaminesornasalcorticosteroids,butmaycausemoodchangesorliverproblems.Montelukastisacommonleukotrienereceptorantagonistusedinchildren.

Immunotherapy,alsoknownasallergyshots,isalong-termtreatmentthatinvolvesregularinjectionsofsmallamountsofallergenstodesensitizetheimmunesystem.Itcanreducetheseverityandfrequencyofallergicrhinitissymptoms,butrequiresacommitmentofseveralyearsandmaycauselocalreactionsoranaphylaxis.Immunotherapyisusuallyreservedforchildrenwithsevereorpersistentallergicrhinitisthatcannotbecontrolledwithothertreatments.

Inconclusion,allergicrhinitisisacommonconditionaffectingmanychildrenworldwide.Itcanhaveasignificantimpactonqualityoflifeandacademicperformance,andmayleadtocomplicationssuchassinusitisorasthma.TreatmentoptionsincludeShufengXingbitherapy,aswellasnasalcorticosteroids,antihistamines,decongestants,leukotrienereceptorantagonists,andimmunotherapy.Thechoiceoftreatmentshouldbebasedontheseverityanddurationofsymptoms,aswellasthepotentialbenefitsandrisksforeachindividualchild.FurtherresearchisneededtoimproveourunderstandingoftheunderlyingmechanismsandoptimalmanagementstrategiesforallergicrhinitisinchildrenInadditiontomedicaltreatment,therearealsonon-pharmacologicaloptionsthatcanhelpmanageallergicrhinitisinchildren.Theseinclude:

1.Allergenavoidance:Identifyingandavoidingtheallergensthattriggersymptomscanbehelpful.Commonallergensincludedustmites,animaldander,pollen,andmold.Measuressuchasusinghypoallergenicbedding,keepingpetsoutofthebedroom,andregularlycleaningandvacuumingcanhelpreduceexposuretoallergens.

2.Nasalsalineirrigation:Salineirrigationcanhelpclearthenasalpassagesofmucusandallergens.Itinvolvesusingasaltwatersolutiontoflushoutthenasalpassages,eitherbyusingasyringe,netipot,orspecializednasalirrigationdevice.

3.Steaminhalation:Inhalingsteamcanhelprelievenasalcongestionandreduceinflammation.Thiscanbedonebytakingahotshowerorusingahumidifier.

4.Dietarymodifications:Certainfoodsmaytriggerallergicreactionsorexacerbatesymptomsofallergicrhinitis.Forexample,somepeoplemaybeallergictodairyorgluten.Aneliminationdietcanhelpidentifywhichfoodsmaybecontributingtosymptoms.

5.Acupuncture:Somestudiessuggestthatacupuncturemaybeeffectiveinreducingsymptomsofallergicrhinitis,althoughmoreresearc