目錄TOC\o"1-4"\h\z\u72721.工藝概述 191171.1鹽酸非索非那定膠囊的概述 Designofproductionworkshopwithanannualoutputof300millionfexofenadinehydrochloridecapsulesAbstract:FexofenadinehydrochloridecapsulesareantihistamineswithselectiveperipheralH1receptorantagonism.Fexofenadinecannotcrosstheblood-brainbarrierandhasnocalmingeffectoranticholinergicagent.Clinically,antihistaminesarecommonlyusedinthetreatmentofallergicrhinitis.Fexofenadinehydrochloridecapsuleisanewgenerationofnon-sedativeantihistamines,whichhastheadvantagesofreceptorselectivity,cleartarget,rapidmetabolism,andfewadversereactions.ThemechanismofitstreatmentofallergicrhinitisisthatH1receptorandhistaminecompetewithhistaminetoeffecthistaminereceptorsonthecellmembraneandplayitsrolerapidlyandslowlyRelievethepatient'snasalitch,sprayandhypersecretionofnasalsecretion.Fexofenadinehydrochloridecapsuleisathirdgenerationantihistamine,whichismoreeffectiveandhasfewersideeffectsthanthesecondgenerationantihistaminescurrentlyusedinthemarket,terphenadine(Mindy),astimidazole(temistine),loratadine,andcetirizinehydrochloride,especiallywithlowcardiactoxicity.Itssafetyisgood,suitableforlarge-scaleproduction,combinedwiththeproductionprocessoffexofenadinehydrochloridecapsules,materialbalance,selecttheappropriateequipment,determinethecorrectflowofpeopleandlogistics,designtheoveralllayoutoftheworkshop,completetheproductionworkshopdesignoffexofenadinehydrochloridecapsules,maketheworkshopsafeandorderlyproduction,andprovideeffectivebasisforthemassproductionoffexofenadinehydrochloridecapsulesAccordingto.Keywords:Fexofenadinehydrochloride;Workshopdesign;Capsules.

附錄附錄I設備一覽表序號設備名稱規(guī)格型號生產能力臺數產地1粉碎機FS180-4C10-120kg/h1廣州雷邁機械設備有限公司2篩分機ZSY-35060-200kg/h1天津市云飛機械有限公司3混合制粒機HLSG-300P40-100kg/h1浙江明天機械有限公司4干燥器CT-C-O20-60kg/h1常州市常鑫藥化機械廠5整粒機GZL-8050-100kg/h1青州市精誠醫(yī)藥裝備制造有限公司6三維運動混合機SYH-400200kg1常州市久川干燥設備有限公司7填充機NJP1500A90000粒/h3北京嘉福瑞科有限公司8拋光機WK-9018萬粒-42萬粒1山東青州精誠機械有限公司9鋁塑包裝機DPB-250D3.5-23萬粒2瑞安