AbMole丨Resveratrol（白藜蘆醇）：調(diào)控SIRT1、Nrf2與NF-κB信號(hào)通路的多靶點(diǎn)天然產(chǎn)物AbMole丨Resveratrol（白藜蘆醇）：調(diào)控氧化應(yīng)激、炎癥反應(yīng)與能量代謝的多功能天然小分子Resveratrol（白藜蘆醇，AbMole，M2267）是一種廣泛存在于葡萄、漿果及花生等植物中的天然產(chǎn)物，因其多樣的生物活性成為多個(gè)領(lǐng)域中的重要研究工具。其作用機(jī)制涉及抗氧化、抗炎、細(xì)胞衰老及對(duì)細(xì)胞信號(hào)通路的調(diào)節(jié)。Resveratrol（白藜蘆醇）不僅可通過(guò)激活去乙?；窼irtuin1（SIRT1）以影響免疫反應(yīng)、能量代謝及細(xì)胞衰老等過(guò)程ADDINEN.CITEADDINEN.CITE.DATA[1]，還可以通過(guò)對(duì)PI3K/AKT、Wnt、NF-κB及Notch等信號(hào)通路的調(diào)控進(jìn)而誘導(dǎo)細(xì)胞衰老，抑制細(xì)胞活力與集落形成ADDINEN.CITEADDINEN.CITE.DATA[2]。Resveratrol在小鼠模型中被發(fā)現(xiàn)可提升小鼠線粒體的功能、體力和葡萄糖耐受，并預(yù)防和緩解與衰老相關(guān)的癥狀A(yù)DDINEN.CITE<EndNote><Cite><Author>Park</Author><Year>2012</Year><RecNum>1445</RecNum><DisplayText><styleface="superscript">[3]</style></DisplayText><record><rec-number>1445</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764035385">1445</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Park,Sung-Jun</author><author>Ahmad,Faiyaz</author><author>Philp,Andrew</author><author>Baar,Keith</author><author>Williams,Tishan</author><author>Luo,Haibin</author><author>Ke,Hengming</author><author>Rehmann,Holger</author><author>Taussig,Ronald</author><author>Brown,Alexandra

L</author><author>Kim,Myung

K</author><author>Beaven,Michael

A</author><author>Burgin,Alex

B</author><author>Manganiello,Vincent</author><author>Chung,Jay

H</author></authors></contributors><titles><title>ResveratrolAmelioratesAging-RelatedMetabolicPhenotypesbyInhibitingcAMPPhosphodiesterases</title><secondary-title>Cell</secondary-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><pages>421-433</pages><volume>148</volume><number>3</number><dates><year>2012</year></dates><publisher>Elsevier</publisher><isbn>0092-8674</isbn><urls><related-urls><url>/10.1016/j.cell.2012.01.017</url></related-urls></urls><electronic-resource-num>10.1016/j.cell.2012.01.017</electronic-resource-num><access-date>2025/11/24</access-date></record></Cite></EndNote>[3]。在抗氧化方面，Resveratrol可直接清除活性氧（ROS）并調(diào)節(jié)細(xì)胞的氧化應(yīng)激水平ADDINEN.CITEADDINEN.CITE.DATA[4]，例如Resveratrol可通過(guò)激活轉(zhuǎn)錄因子Nrf2促進(jìn)抗氧化基因表達(dá)，并在細(xì)胞（如Hacat人角質(zhì)形成細(xì)胞）中表現(xiàn)出抑制氧化損傷的能力ADDINEN.CITEADDINEN.CITE.DATA[5]。在免疫調(diào)節(jié)領(lǐng)域，Resveratrol（白藜蘆醇，AbMole，M2267）表現(xiàn)出抗炎特性。例如Resveratrol可通過(guò)調(diào)節(jié)胞內(nèi)的PPAR、AMPK和FoxO等通路影響小膠質(zhì)細(xì)胞的活性，進(jìn)而發(fā)揮抗炎的作用ADDINEN.CITE<EndNote><Cite><Author>Zhang</Author><Year>2010</Year><RecNum>1443</RecNum><DisplayText><styleface="superscript">[6]</style></DisplayText><record><rec-number>1443</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764034822">1443</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Zhang,Feng</author><author>Liu,Jie</author><author>Shi,Jing-Shan%JEuropeanjournalofpharmacology</author></authors></contributors><titles><title>Anti-inflammatoryactivitiesofresveratrolinthebrain:roleofresveratrolinmicroglialactivation</title></titles><pages>1-7</pages><volume>636</volume><number>1-3</number><dates><year>2010</year></dates><isbn>0014-2999</isbn><urls></urls></record></Cite></EndNote>[6]。并且Resveratrol可抑制由Aβ1-42（Amyloidβ-Peptide1-42）在小膠質(zhì)細(xì)胞和星形膠質(zhì)細(xì)胞中引起的炎癥反應(yīng)，其機(jī)制涉及對(duì)NF-κB信號(hào)通路的抑制ADDINEN.CITE<EndNote><Cite><Author>Zhao</Author><Year>2018</Year><RecNum>1444</RecNum><DisplayText><styleface="superscript">[7]</style></DisplayText><record><rec-number>1444</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764034983">1444</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Zhao,Haifeng</author><author>Wang,Qian</author><author>Cheng,Xuejiao</author><author>Li,Xuemin</author><author>Li,Na</author><author>Liu,Tiantian</author><author>Li,Jing</author><author>Yang,Qian</author><author>Dong,Ruirui</author><author>Zhang,Yusen%JNeuroscience</author></authors></contributors><titles><title>InhibitiveeffectofresveratrolontheinflammationinculturedastrocytesandmicrogliainducedbyAβ1–42</title></titles><pages>390-404</pages><volume>379</volume><dates><year>2018</year></dates><isbn>0306-4522</isbn><urls></urls></record></Cite></EndNote>[7]。Resveratrol還可影響細(xì)胞和機(jī)體的代謝，其機(jī)制涉及對(duì)cAMP降解磷酸二酯酶的競(jìng)爭(zhēng)性抑制，導(dǎo)致cAMP水平升高，并影響細(xì)胞中的能量調(diào)節(jié)中樞--cAMP-MAPK通路ADDINEN.CITE<EndNote><Cite><Author>Park</Author><Year>2012</Year><RecNum>1445</RecNum><DisplayText><styleface="superscript">[3]</style></DisplayText><record><rec-number>1445</rec-number><foreign-keys><keyapp="EN"db-id="f2td9w00a22awteprfrp9vaup9d9zwa9tdfr"timestamp="1764035385">1445</key></foreign-keys><ref-typename="JournalArticle">17</ref-type><contributors><authors><author>Park,Sung-Jun</author><author>Ahmad,Faiyaz</author><author>Philp,Andrew</author><author>Baar,Keith</author><author>Williams,Tishan</author><author>Luo,Haibin</author><author>Ke,Hengming</author><author>Rehmann,Holger</author><author>Taussig,Ronald</author><author>Brown,Alexandra

L</author><author>Kim,Myung

K</author><author>Beaven,Michael

A</author><author>Burgin,Alex

B</author><author>Manganiello,Vincent</author><author>Chung,Jay

H</author></authors></contributors><titles><title>ResveratrolAmelioratesAging-RelatedMetabolicPhenotypesbyInhibitingcAMPPhosphodiesterases</title><secondary-title>Cell</secondary-title></titles><periodical><full-title>Cell</full-title><abbr-1>Cell</abbr-1></periodical><pages>421-433</pages><volume>148</volume><number>3</number><dates><year>2012</year></dates><publisher>Elsevier</publisher><isbn>0092-8674</isbn><urls><related-urls><url>/10.1016/j.cell.2012.01.017</url></related-urls></urls><electronic-resource-num>10.1016/j.cell.2012.01.017</electronic-resource-num><access-date>2025/11/24</access-date></record></Cite></EndNote>[3]。AbMole為全球科研客戶提供高純度、高生物活性的抑制劑、細(xì)胞因子、人源單抗、天然產(chǎn)物、熒光染料、多肽、化合物庫(kù)、抗生素等科研試劑，全球大量文獻(xiàn)專(zhuān)利引用。范例詳解

Biomaterials.2025Aug;319:123208.天津大學(xué)的科研人員在上述文章中使用了AbMole的Resveratrol（白藜蘆醇，AbMole，M2267）進(jìn)行了以下研究：首先實(shí)驗(yàn)人員開(kāi)發(fā)了一種基于磷脂酰肌醇衍生物的新型生物正交標(biāo)記策略，用于熒光標(biāo)記來(lái)自各種人類(lèi)和小鼠細(xì)胞類(lèi)型的外泌體。發(fā)現(xiàn)不同細(xì)胞來(lái)源的外泌體表現(xiàn)出器官特異性分布模式和良好的安全性特征。值得注意的是，4T1細(xì)胞（一種乳腺癌細(xì)胞）來(lái)源的外泌體專(zhuān)門(mén)針對(duì)肺部，當(dāng)其用作含有抗炎白藜蘆醇（AbMole，M2267）的活性分子載體時(shí)，在急性呼吸窘迫綜合征（ARDS）小鼠中表現(xiàn)出顯著的癥狀抑制效果，有效減少了炎癥反應(yīng)和肺纖維化，并恢復(fù)肺組織的形態(tài)和功能ADDINEN.CITEADDINEN.CITE.DATA[8]。2014年，AbMole的兩款抑制劑分別被西班牙國(guó)家心血管研究中心和美國(guó)哥倫比亞大學(xué)用于動(dòng)物體內(nèi)實(shí)驗(yàn)，相關(guān)科研成果發(fā)表于頂刊Nature和NatureMedicine。EvaluatingthetherapeuticefficacyoftheExo(R)fortreatingARDSmouseADDINEN.CITEADDINEN.CITE.DATA[8].AbMole是ChemBridge中國(guó)區(qū)官方指定合作伙伴。*本文所述產(chǎn)品僅供科研使用參考文獻(xiàn)及鳴謝ADDINEN.REFLIST[1] MaF,MaY,LiuK,etal.ResveratrolinducesDNAdamage-mediatedcancercellsenescencethroughthedlc1-dyrk1a-egfraxis.Food&function,2023,14:1484-1497[2] Ghafouri-FardS,BahroudiZ,ShooreiH,etal.Disease-associatedregulationofgeneexpressionbyresveratrol:Specialfocusonthepi3k/aktsignalingpathway.Cancercellinternational,2022,22:298[3] ParkS-J,AhmadF,PhilpA,etal.Resveratrolamelioratesaging-relatedmetabolicphenotypesbyinhibitingcampphosphodiesterases.Cell,2012,148:421-433[4] AgbaduaOG,KuszN,BerkeczR,etal.Oxidizedresve