1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMacropa-NH2 hydrochlorideCat. No.: HY-111895A分式: CHClNO分量: 584.06作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 83.33 mg/mL (142.67 mM; Need ultrasonic)Mass Solvent1

2、mg 5 mg 10 mg Concentration制備儲備液1 mM 1.7122 mL 8.5608 mL 17.1215 mL5 mM 0.3424 mL 1.7122 mL 3.4243 mL10 mM 0.1712 mL 0.8561 mL 1.7122 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶

3、液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.56 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (3.56 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (3.56 mM); Clear solution1/2 Mast

4、er of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Macropa-NH2 hydrochloride是Macropa-NCS 的前體。Macropa-NCS 能與曲妥珠單抗以及前列腺特異性膜抗原靶向化合物 RPS-070 結(jié)合， 種可應(yīng)于治療軟組織轉(zhuǎn)移瘤的放射性核素 1 2。REFERENCES1. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem

5、Int Ed Engl. 2017Nov 13;56(46):14712-14717.2. Thiele NA, et al. An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017Nov 13;56(46):14712-14717.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895