1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMB05032Cat. No.: HY-16307CAS No.: 261365-11-1分式: CHNOPS分量: 302.29作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (165.40 mM; Need ultrasonic)Mass Solvent1 mg

2、5 mg 10 mg Concentration制備儲備液1 mM 3.3081 mL 16.5404 mL 33.0808 mL5 mM 0.6616 mL 3.3081 mL 6.6162 mL10 mM 0.3308 mL 1.6540 mL 3.3081 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中

3、的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.27 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.27 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.27 mM); Clear solution1/2 Master of

4、 Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 MB05032是GNG 抑制劑，能靶向果糖-1，6-雙磷酸酯酶的AMP結(jié)合位點(diǎn)，IC50為 16 nM。IC50 & Target IC50: 16 nM (Human Liver FBPase) 1體內(nèi)研究 MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZD

5、F rats with mild diabetes and aged ZDF rats with overt diabetes 1.Animal Model: ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes) 1Dosage: 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats)Administration: Oral administration; onceResult: R

6、esults in dose-dependent glucose lowering.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Nat Med. 2018 Sep;24(9):1395-1406. Cell Metab. 2018 Aug 7;28(2):243-255.e5.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase fo

7、r controlling gluconeogenesis intype 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.2. Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.Endocrinology. 2010 Oct;151(10):4688-95.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use