1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE(Z)-CapsaicinCat. No.: HY-B1583CAS No.: 25775-90-0Synonyms: Zucapsaicin; Civamide; cis-Capsaicin分式: CHNO分量: 305.41作靶點: TRP Channel作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: 4C, protect from light* In solvent :

2、 -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實驗 DMSO : 125 mg/mL (409.29 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.2743 mL 16.3714 mL 32.7429 mL5 mM 0.6549 mL 3.2743 mL 6.5486 mL10 mM 0.3274 mL 1.6371 mL 3.2743 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的

3、溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.81 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in sali

4、ne)Solubility: 2.08 mg/mL (6.81 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (6.81 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 (Z)-Capsaicincapsaicin 的 式異構(gòu)體，為可服的 TRPV1 激動劑，可于神經(jīng)性疼痛的研究。IC50 & Target TRPV1 receptor 1體外研究 (Z)

5、-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks theneruonal calcium channel 1.體內(nèi)研究 (Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurr

6、ent experimental genital herpes simplex virus infection inguinea pigs 1.REFERENCES1. Bourne N, et al. Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes. Antimicrob AgentsChemother. 1999 Nov;43(11):2685-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8