1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIvabradine hydrochlorideCat. No.: HY-B0162ACAS No.: 148849-67-6分式: CHClNO分量: 505.05作靶點(diǎn): Adrenergic Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DM

2、SO : 51 mg/mL (100.98 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9800 mL 9.9000 mL 19.8000 mL5 mM 0.3960 mL 1.9800 mL 3.9600 mL10 mM 0.1980 mL 0.9900 mL 1.9800 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ivabradine hydroch

3、loride可服的，超極化激活的環(huán)核苷酸門控離通道 (HCN) 通道阻滯劑。體內(nèi)研究Ivabradine hydrochloride treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LVfunction probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxidebioavailability, resulting from processes triggered early af

4、ter HRR initiation: angiogenesis and/or preservationof endothelial nitric oxide synthase expression 1. Ivabradine hydrochloride leads to a sustained 15-20%1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEheart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on end

5、othelialfunction and vascular reactive oxygen species production in angiotensin II-treated rats, it improves bothparameters in ApoE knockout mice. Ivabradine hydrochloride treatment leads to an attenuation ofangiotensin II signaling and increased the expression of telomere-stabilizing proteins in Ap

6、oE knockout mice,which may explain its beneficial effects on the vasculature. The absence of these protective ivabradineeffects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterialhypertension 2.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) J Cell Physiol. 2019 Feb;234(2):1925-1936.See more

7、 customer validations on HYPERLINK / www.MedChemEREFERENCES1. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiactissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7.2. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidativestress. Basic Res Cardiol, 2011. 106(6): p. 1147-58.McePdfHeightCaution: Product has not been fully validated for medical applications.For re