1ScheduleofDermatology&VenereologyLectureNo.DateContentsTimeTeacher12-26Generalconsideration(1)2hXinsuoDuan23-5Generalconsideration(2)2hXinsuoDuan33-12Generalconsideration(3)2hXinsuoDuan43-19Viraldermatoses&Bacteriadermatoses2hShupingYu53-26Fungaldermatoses2hShupingYu64-2STD(1)syphilis，AIDS2hXinsuoDuan74-9STD(2)gonorrhea,NGU,CA,chancroid2hXinsuoDuan84-16Eczema&Dermatitis(1)2hJinWang94-23Eczema&Dermatitis(2)2hJinWang104-30Drugeruption2hJingliangWu115-7Urticaria2hJingliangWu125-14Papulosquamousdiseases2hBaoqiangLi135-21BullousDermatoses2hBaoqiangLi145-28Cutaneousvasculitis2hBaoqiangLi156-4Skinappendages2hBaoqiangLi166-11Vitiligo&Skintumors2hBaoqiangLi176-18Practice2h

186-25Test2h

1ScheduleofDermatology&Vener2SectionⅠ

GeneralConsiderationIntroductionStructureofSkinFunctionofSkinSymptom,SignandDiagnosisofDermatosesTreatmentofDermatoses2SectionⅠ

GeneralConsiderati3IntroductionTheskinisthelargestorganofthebodyTherearemorethan2000kindofskindiseaseinDermatology3IntroductionTheskinistheChapterⅠ

StructureofskinChapterⅠ

Structureofskin5561.Epidermis(structure)61.Epidermis(structure)71.EpidermiscellskeratinocytemelanocyteLangerhanscellMerkelcell71.EpidermiscellsGeneralconsideration(3)nailoffinger0.Hemi-desmosomeIntroduction（4）eccrineglands（2）MelanocyteCorrelatewithtensityofskin(3)Langerhanscellnailoffinger0.ShupingYuthebuccalmucosaThedeeper,lowerhorizontalplexusisfoundatthedermal-subcutaneousinterfaceandiscomposedoflargerbloodvesselsthanthoseofthesuperficialplexus.vermilionborderofthelip(Fordyce'sspots)vermilionborderofthelip(Fordyce'sspots)Thecoiledsecretoryglandislocatedatthejunctionofthedermisandsubcutaneousfat.Smoothness：AbsorptionThepaleglycogen-richcellsformsweat4mm/d×365d/y×10ythebuccalmucosa8（1）Keratinocyte④③②①Generalconsideration(3)8（1）K9910Hemi-desmosome10Hemi-desmosome11（1）Keratinocyte④③②①11（1）Keratinocyte④12desmosomehemi-desmosomeDesmosome&Hemi-desmosome12desmosomehemi-desmosomeDesmo13Desmosome13Desmosome14Hemi-desmosome14Hemi-desmosome15desmosomehemi-desmosomeDesmosome&Hemi-desmosome15desmosomehemi-desmosomeDesmo16（1）Keratinocyte④③②①28d16（1）Keratinocyte④28dItopensintotheinfundibularportionofthehairfollicle.Shorthair：eyebrows,eyelids,noseandauditorymeatesWatermetabolismXinsuoDuanFunctionofSkinTheyarealwaysassociatedwithhairfolliclesexceptatthefollowingsites:Increasedsweatproductioninresponsetoheatispartofthethermoregulatorysystemofthebody;togetherwithincreasedcutaneousbloodflow,itcaneffectivelydissipateexcessivebodyheat.vermilionofthelipOtherphysiologicstimuli,includingemotionalstress,areimportantaswell.containintracytoplasmicneurosecretory-likegranules,and,throughtheirassociationwithneurites,actasslowadaptingtouchreceptors.theexternalauditorycanal(ceruminousglands),distributiontheprepuce(Tyson'sglands)Theglandsdonotbegintofunctionuntilpuberty.PapulosquamousdiseasesantigenpresentingcellCutaneousvasculitisJingliangWuHypodermis(subcutaneoustissue)metabolismandimmuneThedeeper,lowerhorizontalplexusisfoundatthedermal-subcutaneousinterfaceandiscomposedoflargerbloodvesselsthanthoseofthesuperficialplexus.17（2）Melanocytemelanocytepigment-producingcellItopensintotheinfundibular1818Theyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.SectionⅠ

GeneralConsiderationRestingphaseAssociatedwiththevascularplexusarethedermallymphatics.Theskinalsoplaysanimportantroleinimmunizationofthebody.Sweatissecretedbythesweatglandsandgivesafunctionofdiscipatingheat.vermilionofthelipTheyaremostabundantontheAbsorptionproteinmetabolismtheexternalauditorycanal(ceruminousglands),4mm/d，loss70-100/d）mammarypapillatheprepuce(Tyson'sglands)hairfollicleBaoqiangLimetabolismandimmuneTheyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.reticularedermisJinWangtheexternalauditorycanal(ceruminousglands),19（2）MelanocyteTheyaredistributedthroughou2020212122（2）Melanocyte22（2）Melanocyte23(3)Langerhanscell

Langerhanscellantigenpresentingcell23(3)LangerhanscellLangerha24(3)LangerhanscellLangerhanscells(CD1a)24(3)LangerhanscellLangerhan25(4)Merkelcell

Merkelcellcontainintracytoplasmicneurosecretory-likegranules,and,throughtheirassociationwithneurites,actasslowadaptingtouchreceptors.25(4)MerkelcellMerkelcellc26(4)Merkelcellinthebasallayerofthepalmsandsoles,theoralandgenitalmucosa,thenailbed,andthefollicularinfundibula.

26(4)MerkelcellinthebasalBefoundingreatestabundanceonthefaceandscalp.XinsuoDuan4mm/d×365d/y×10yRestingphasetheexternalauditorycanal(ceruminousglands),RestingphaseThepaleglycogen-richcellsformsweat（4）eccrineglandssebaceousglandsLength(1000~1500mm)=0.vermilionborderofthelip(Fordyce'sspots)Langerhanscells(CD1a)MetabolismIncreasedsweatproductioninresponsetoheatispartofthethermoregulatorysystemofthebody;togetherwithincreasedcutaneousbloodflow,itcaneffectivelydissipateexcessivebodyheat.Theyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.elasticfiberssecretionandexcretion（4）eccrineglandsdecapitationsecretion272.Dermiscollagenfiberreticularfiberelasticfibersbasematerial（groundsubstance）：proteoglycanCells:FibroblastmastcellMacrophagedermicarborescentcellLanggerhanscellPigmentophageLymphocyteleukocyteBefoundingreatestabundance282.Dermiscollagenfibers282.Dermiscollagenfibersthefemaleareolas(Montgomery'stubercles).Asignificantamountofmetabolicwastesandsaltsisdisposedfromthesweat.Thepaleglycogen-richcellsformsweatSkinappendagestheexternalauditorycanal(ceruminousglands),eccrineglandseccrineglandscarbohydrateandsaltmetabolismregulationofcutaneousbloodflow,reticularfiber（4）eccrineglandsSebumisexcretedbythesebaceousglandthroughtheorificeofhairfollicle,thesebummaylubricatetheskinandhair,andgiveafunctionofantibacterialandantifungalproperities.DrugeruptionSkinappendagesDesmosome&Hemi-desmosomecarbohydrateandsaltmetabolismWatermetabolismAssociatedwiththevascularplexusarethedermallymphatics.Pigmentophagemetabolismandimmune(4)MerkelcellnailgrooveSecretionandExcretionItiscomposedofadoublelayerofcuboidalepithelialcells.SkinappendagesBaoqiangLiInnerrootsheath(4)MerkelcellPressureismediatedbyVater-Pacinicorpuscleswhichlocateinthedeeperportionofthedermisofweight-bearingsurfaces.Longhairgirldistributiondistribution1mm/d，toenail0.Heatisaprimestimulustoincreasedsweating,(3)Langerhanscell（1）Keratinocyte（2）sebaceousglandsCorrelatewithtensityofskindistributionItiscomposedofadoublelayerofcuboidalepithelialcells.theexternalauditorycanal(ceruminousglands),Thepaleglycogen-richcellsformsweat29reticularfiberthefemaleareolas(Montgomery302.DermiselasticfibersCorrelatewithtensityofskin302.DermiselasticfibersCorrel312.Dermisreticularedermispapillarydermis312.Dermisreticularedermispap323.Hypodermis(subcutaneoustissue)Hypodermis323.Hypodermis(subcutaneoust333.Hypodermis(subcutaneoustissue)333.Hypodermis(subcutaneoust344.Appendageshairfolliclesebaceousglandseccrineglandsapocrineglandsnail344.Appendageshairfollicle35（1）HairandHairfollicleHair：LonghairShorthairWollyhairEpidermisSebaceousglandsHairrootMedullaryHaircuticleCortexInnerrootsheathOuterrootsheathHairmatrixHairpapilla35（1）HairandHairfollicleHai36DistributionofhairLonghair：scalp,beard,axillaeandpubesShorthair

：eyebrows,eyelids,noseandauditorymeatesSmoothness：vermilionofthelipmammarypapillaPalm,soles,sideofthefingersandtoes,nailbeds,andcertainareasadjacenttomucosalsurface,suchastheglanspenisvellushair(Wollyhair)：

face,neckandtrunk36DistributionofhairLonghai37Hairgrowthcycle

（speed0.27~0.4mm/d，loss70-100/d）

anagen3-10yGrowingphase

catagen3-4wTransitionalphase

telogen3mRestingphase37Hairgrowthcycle

（speed0.238LonghairgirlLength(1000~1500mm)=0.27~0.4mm/d×365d/y×10y38LonghairgirlLength(1000~1539（2）SebaceousglandsItiscomposedoflobulesofpale-stainingcellswithabundantlipidintheircytoplasm.

39（2）SebaceousglandsItiscom40distributionBefoundingreatestabundanceonthefaceandscalp.Theyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.Theyarealwaysassociatedwithhairfolliclesexceptatthefollowingsites:theeyelids(meibomianglands),thebuccalmucosavermilionborderofthelip(Fordyce'sspots)theprepuce(Tyson'sglands)thefemaleareolas(Montgomery'stubercles).40distributionBefoundingrea41（2）sebaceousglandsDiseases:Comedopapulepustulecyst

41（2）sebaceousglandsDiseases:42Itopensintotheinfundibularportionofthehairfollicle.Thecoiledsecretoryglandislocatedatthejunctionofthedermisandsubcutaneousfat.（3）Apocrineglands42Itopensintotheinfundibul43（3）ApocrineglandsdecapitationsecretionItiscomposedofadoublelayerofcuboidalepithelialcells.43（3）ApocrineglandsdecapitatimetabolismandimmuneThepaleglycogen-richcellsformsweatProtectionItiscomposedofadoublelayerofcuboidalepithelialcells.（3）ApocrineglandsUrticariametabolismandimmune(4)MerkelcellFunctionofSkinproteinmetabolismLength(1000~1500mm)=0.Itopensintotheinfundibularportionofthehairfollicle.(3)Langerhanscellproteinmetabolism(4)MerkelcellImmuneFunctionsebaceousglandsLangerhanscells(CD1a)BaoqiangLiShupingYuGeneralconsideration(1)Watermetabolism44Apocrineunitsofthehumanbodyaregenerallyconfinedtothefollowingsites:axillae,areolae,theanogenitalregion,theexternalauditorycanal(ceruminousglands),andtheeyelids(glandsofMoll).

Theglandsdonotbegintofunctionuntilpuberty.（3）Apocrineglandsmetabolismandimmune44Apocrin45（4）eccrineglands45（4）eccrineglands46（4）eccrineglandscellsareoftwotypes:glycogen-rich,largepalecellssmaller,darkerstainingcellsThepaleglycogen-richcellsformsweat46（4）eccrineglandscellsareo47（4）eccrineglandsThedarkercellsmayactivelyreabsorbsodium,therebymodifyingsweatfromabasicallyisotonicsolutiontoahypotoniconebythetimeitreachestheskinsurface.Sweatissimilarincompositiontoplasma,containingthesameelectrolytes,thoughinamorediluteconcentration.47（4）eccrineglandsThedarker48RegulationSecretionofsweatoccursasresultofmanyfactorsandis

mediatedbycholinergicinnervation.Heatisaprimestimulustoincreasedsweating,Otherphysiologicstimuli,includingemotionalstress,areimportantaswell.Increasedsweatproductioninresponsetoheatispartofthethermoregulatorysystemofthebody;togetherwithincreasedcutaneousbloodflow,itcaneffectivelydissipateexcessivebodyheat.Atfrictionsurfaces,suchasthepalmsandsoles,eccrinesecretionisthoughttoassisttactilesensibilityandimproveadhesion.48RegulationSecretionofsweat49distributionEccrinesweatunitsarefoundatvirtuallyallskinsitesexceptthevermillionborderofthelips,nailbeds,labiaminora,glanspenis,andinneraspectoftheprepuce.

Theyaremostabundantonthepalms,soles,forehead,axillae.Someeccrineglandsintheaxillae,especiallyinpatientswithhyperhidrosis,mayhavewidelydilatedsecretarycoilsthatcontainapocrine-appearingcells.49distributionEccrinesweatu50（5）nailnailfoldsnaillunula

nailplatefreemarginofnailnailgroovegrowthvelocity：nailoffinger0.1mm/d，toenail0.1cm/3dnailfoldsnailplatenailbednailrootnailmatrixdigitalbone50（5）nailnailfoldsnaillunula51Vasculaturethreeimportantintercommunicatingplexuses:

thesubpapillaryplexusupperhorizontalnetworkThedeeper,lowerhorizontalplexusisfoundatthedermal-subcutaneousinterfaceandiscomposedoflargerbloodvesselsthanthoseofthesuperficialplexus.Thevasculatureofthedermisisparticularlywelldevelopedatsitesofadnexalstructures.Associatedwiththevascularplexusarethedermallymphatics.5.Vasculature,Muscles,andNervesofskin51Vasculature5.Vasculature,525253muscleSmoothmuscleoccursintheskinasarrectorespilorum(erectorsofthehairs),asthetunicadartos(ordartos)ofthescrotum,andintheareolasaroundthenipples.Thearrectorespilorumareattachedtothehairfolliclesbelowthesebaceousglandsand,incontracting,pullthehairfollicleupward,producinggooseflesh.5.Vasculature,Muscles,andNervesofskinmuscle53muscle5.Vasculature,Muscl545.Vasculature,Muscles,andNervesofskinNerves

：

TouchismediatedbyMeissnercorpusclesandinthedermalpapillae,particularlyonthepalmsandsoles

PressureismediatedbyVater-Pacinicorpuscleswhichlocateinthedeeperportionofthedermisofweight-bearingsurfaces.Temperature,pain,anditchsensationaretransmittedbyunmyelinatednervefiberswhichterminateinthepapillarydermisandaroundhairfollicles.

545.Vasculature,Muscles,aAppendagesRestingphaseCutaneousvasculitisHairgrowthcycle

（speed0.Thecomeumstratum,hairfollicleandsebaceousglandarethemainpath.Vasculature,Muscles,andNervesofskindecapitationsecretionThepaleglycogen-richcellsformsweatthefemaleareolas(Montgomery'stubercles).Therearemorethan2000kindofskindiseaseinDermatologyBaoqiangLiShorthair：eyebrows,eyelids,noseandauditorymeatesItiscomposedofadoublelayerofcuboidalepithelialcells.Desmosome&Hemi-desmosomevermilionborderofthelip(Fordyce'sspots)andmuscleactivity,includingshivering(resultinginwarmth).Itiscomposedofadoublelayerofcuboidalepithelialcells.（4）eccrineglandsEccrinesweatunitsarefoundatvirtuallyallskinsitesexceptthevermillionborderofthelips,nailbeds,labiaminora,glanspenis,andinneraspectoftheprepuce.nailgrooveThecomeumstratum,hairfollicleandsebaceousglandarethemainpath.thebuccalmucosaChapterⅡ

FunctionofSkinAppendagesChapterⅡ

Function56Theskin'sfunctionsincludeProtectionAbsorptionSensationsecretionandexcretiontemperatureregulationmetabolismandimmuneFunctionofSkin56Theskin'sfunctionsinclud571.ProtectionPhysicalProtectionChemicalProtectionProtectionagainstpathogenicmicro-organismsPreventthelossoffluid,electrolyteandnutrientsubstance.571.ProtectionPhysicalProtec582.AbsorptionThecomeumstratum,hairfollicleandsebaceousglandarethemainpath.Theabsorptioncanbeaffectedbysomefacors:structureandsiteoftheskin,hydrationofthecorneumstratum,natureofthesubstance,environmentfactors582.AbsorptionThecomeumstr593.SensationThebodyinterpretsexternalstimuliasheat,cold,pain,lighttouch,pressure,itch,andeventickleheatcold593.SensationThebodyinterpre604.SecretionandExcretionSweatissecretedbythesweatglandsandgivesafunctionofdiscipatingheat.Asignificantamountofmetabolicwastesandsaltsisdisposedfromthesweat.Sebumisexcretedbythesebaceousglandthroughtheorificeofhairfollicle,thesebummaylubricatetheskinandhair,andgiveafunctionofantibacterialandantifungalproperities.604.SecretionandExcretionS615.TemperatureregulationCutaneousmechanismsoftemperaturecontrolinclude

insulation(primarilysubcutaneousfat),

regulationofcutaneousbloodflow,eccrinesweatactivity(resultingincoolingthroughevaporation),andmuscleactivity,includingshivering(resultinginwarmth).615.TemperatureregulationCut626.MetabolismWatermetabolismcarbohydrateandsaltmetabolismproteinmetabolismlipidandvitaminmetabolismmelaninmetabolism626.MetabolismWatermetabolis637.ImmuneFunctionTheskinalsoplaysanimportantroleinimmunizationofthebody.637.ImmuneFunctionTheskin64Theend!64Theend!65IntroductionTheskinisthelargestorganofthebodyTherearemorethan2000kindofskindiseaseinDermatology65IntroductionTheskinisthemetabolismandimmune4mm/d×365d/y×10yImmuneFunctionThepaleglycogen-richcellsformsweatproteinmetabolismBaoqiangLiBaoqiangLiBaoqiangLidistributionThepaleglycogen-richcellsformsweatSectionⅠ

GeneralConsiderationsecretionandexcretionTheyarealwaysassociatedwithhairfolliclesexceptatthefollowingsites:proteinmetabolismcarbohydrateandsaltmetabolismvellushair(Wollyhair)：face,neckandtrunkelasticfibersThevasculatureofthedermisisparticularlywelldevelopedatsitesofadnexalstructures.Associatedwiththevascularplexusarethedermallymphatics.Theskinalsoplaysanimportantroleinimmunizationofthebody.SkinappendagesChapterⅠ

StructureofskinmetabolismandimmuneChapterⅠ672.Dermisreticularedermispapillarydermis672.Dermisreticularedermispap68（3）ApocrineglandsdecapitationsecretionItiscomposedofadoublelayerofcuboidalepithelialcells.68（3）ApocrineglandsdecapitatiHairpapilla(3)LangerhanscelldecapitationsecretionFunctionofSkinnailgrooveIntroduction(3)LangerhanscellThevasculatureofthedermisisparticularlywelldevelopedatsitesofadnexalstructures.thesubpapillaryplexusLangerhanscells(CD1a)Cutaneousvasculitisvellushair(Wollyhair)：face,neckandtrunkRestingphaseThepaleglycogen-richcellsformsweatmetabolismandimmuneWatermetabolismfreemarginofnailPressureismediatedbyVater-Pacinicorpuscleswhichlocateinthedeeperportionofthedermisofweight-bearingsurfaces.Hemi-desmosome（2）sebaceousglands69Apocrineunitsofthehumanbodyaregenerallyconfinedtothefollowingsites:axillae,areolae,theanogenitalregion,theexternalauditorycanal(ceruminousglands),andtheeyelids(glandsofMoll).

Theglandsdonotbegintofunctionuntilpuberty.（3）ApocrineglandsHairpapilla69Apocrineunitso70distributionEccrinesweatunitsarefoundatvirtuallyallskinsitesexceptthevermillionborderofthelips,nailbeds,labiaminora,glanspenis,andinneraspectoftheprepuce.

Theyaremostabundantonthepalms,soles,forehead,axillae.Someeccrineglandsintheaxillae,especiallyinpatientswithhyperhidrosis,mayhavewidelydilatedsecretarycoilsthatcontainapocrine-appearingcells.70distributionEccrinesweatu714.SecretionandExcretionSweatissecretedbythesweatglandsandgivesafunctionofdiscipatingheat.Asignificantamountofmetabolicwastesandsaltsisdisposedfromthesweat.Sebumisexcretedbythesebaceousglandthroughtheorificeofhairfollicle,thesebummaylubricatetheskinandhair,andgiveafunctionofantibacterialandantifungalproperities.714.SecretionandExcretionSThevasculatureofthedermisisparticularlywelldevelopedatsitesofadnexalstructures.(4)MerkelcellJinWangLangerhanscells(CD1a)Cutaneousvasculitiscellsareoftwotypes:glycogen-rich,largepalecellssmaller,darkerstainingcellsmetabolismandimmuneTheyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.(4)MerkelcellThevasculatureofthedermisisparticularlywelldevelopedatsitesofadnexalstructures.carbohydrateandsaltmetabolismRestingphaseMetabolismfreemarginofnailBaoqiangLiAssociatedwiththevascularplexusarethedermallymphatics.Hypodermis(subcutaneoustissue)CutaneousvasculitisItiscomposedofadoublelayerofcuboidalepithelialcells.ChapterⅠ

Structureofskin726.MetabolismWatermetabolismcarbohydrateandsaltmetabolismproteinmetabolismlipidandvitaminmetabolismmelaninmetabolismThevasculatureofthedermis73ScheduleofDermatology&VenereologyLectureNo.DateContentsTimeTeacher12-26Generalconsideration(1)2hXinsuoDuan23-5Generalconsideration(2)2hXinsuoDuan33-12Generalconsideration(3)2hXinsuoDuan43-19Viraldermatoses&Bacteriadermatoses2hShupingYu53-26Fungaldermatoses2hShupingYu64-2STD(1)syphilis，AIDS2hXinsuoDuan74-9STD(2)gonorrhea,NGU,CA,chancroid2hXinsuoDuan84-16Eczema&Dermatitis(1)2hJinWang94-23Eczema&Dermatitis(2)2hJinWang104-30Drugeruption2hJingliangWu115-7Urticaria2hJingliangWu125-14Papulosquamousdiseases2hBaoqiangLi135-21BullousDermatoses2hBaoqiangLi145-28Cutaneousvasculitis2hBaoqiangLi156-4Skinappendages2hBaoqiangLi166-11Vitiligo&Skintumors2hBaoqiangLi176-18Practice2h

186-25Test2h

1ScheduleofDermatology&Vener74SectionⅠ

GeneralConsiderationIntroductionStructureofSkinFunctionofSkinSymptom,SignandDiagnosisofDermatosesTreatmentofDermatoses2SectionⅠ

GeneralConsiderati75IntroductionTheskinisthelargestorganofthebodyTherearemorethan2000kindofskindiseaseinDermatology3IntroductionTheskinistheChapterⅠ

StructureofskinChapterⅠ

Structureofskin775781.Epidermis(structure)61.Epidermis(structure)791.EpidermiscellskeratinocytemelanocyteLangerhanscellMerkelcell71.EpidermiscellsGeneralconsideration(3)nailoffinger0.Hemi-desmosomeIntroduction（4）eccrineglands（2）MelanocyteCorrelatewithtensityofskin(3)Langerhanscellnailoffinger0.ShupingYuthebuccalmucosaThedeeper,lowerhorizontalplexusisfoundatthedermal-subcutaneousinterfaceandiscomposedoflargerbloodvesselsthanthoseofthesuperficialplexus.vermilionborderofthelip(Fordyce'sspots)vermilionborderofthelip(Fordyce'sspots)Thecoiledsecretoryglandislocatedatthejunctionofthedermisandsubcutaneousfat.Smoothness：AbsorptionThepaleglycogen-richcellsformsweat4mm/d×365d/y×10ythebuccalmucosa80（1）Keratinocyte④③②①Generalconsideration(3)8（1）K81982Hemi-desmosome10Hemi-desmosome83（1）Keratinocyte④③②①11（1）Keratinocyte④84desmosomehemi-desmosomeDesmosome&Hemi-desmosome12desmosomehemi-desmosomeDesmo85Desmosome13Desmosome86Hemi-desmosome14Hemi-desmosome87desmosomehemi-desmosomeDesmosome&Hemi-desmosome15desmosomehemi-desmosomeDesmo88（1）Keratinocyte④③②①28d16（1）Keratinocyte④28dItopensintotheinfundibularportionofthehairfollicle.Shorthair：eyebrows,eyelids,noseandauditorymeatesWatermetabolismXinsuoDuanFunctionofSkinTheyarealwaysassociatedwithhairfolliclesexceptatthefollowingsites:Increasedsweatproductioninresponsetoheatispartofthethermoregulatorysystemofthebody;togetherwithincreasedcutaneousbloodflow,itcaneffectivelydissipateexcessivebodyheat.vermilionofthelipOtherphysiologicstimuli,includingemotionalstress,areimportantaswell.containintracytoplasmicneurosecretory-likegranules,and,throughtheirassociationwithneurites,actasslowadaptingtouchreceptors.theexternalauditorycanal(ceruminousglands),distributiontheprepuce(Tyson'sglands)Theglandsdonotbegintofunctionuntilpuberty.PapulosquamousdiseasesantigenpresentingcellCutaneousvasculitisJingliangWuHypodermis(subcutaneoustissue)metabolismandimmuneThedeeper,lowerhorizontalplexusisfoundatthedermal-subcutaneousinterfaceandiscomposedoflargerbloodvesselsthanthoseofthesuperficialplexus.89（2）Melanocytemelanocytepigment-producingcellItopensintotheinfundibular9018Theyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.SectionⅠ

GeneralConsiderationRestingphaseAssociatedwiththevascularplexusarethedermallymphatics.Theskinalsoplaysanimportantroleinimmunizationofthebody.Sweatissecretedbythesweatglandsandgivesafunctionofdiscipatingheat.vermilionofthelipTheyaremostabundantontheAbsorptionproteinmetabolismtheexternalauditorycanal(ceruminousglands),4mm/d，loss70-100/d）mammarypapillatheprepuce(Tyson'sglands)hairfollicleBaoqiangLimetabolismandimmuneTheyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.reticularedermisJinWangtheexternalauditorycanal(ceruminousglands),91（2）MelanocyteTheyaredistributedthroughou9220932194（2）Melanocyte22（2）Melanocyte95(3)Langerhanscell

Langerhanscellantigenpresentingcell23(3)LangerhanscellLangerha96(3)LangerhanscellLangerhanscells(CD1a)24(3)LangerhanscellLangerhan97(4)Merkelcell

Merkelcellcontainintracytoplasmicneurosecretory-likegranules,and,throughtheirassociationwithneurites,actasslowadaptingtouchreceptors.25(4)MerkelcellMerkelcellc98(4)Merkelcellinthebasallayerofthepalmsandsoles,theoralandgenitalmucosa,thenailbed,andthefollicularinfundibula.

26(4)MerkelcellinthebasalBefoundingreatestabundanceonthefaceandscalp.XinsuoDuan4mm/d×365d/y×10yRestingphasetheexternalauditorycanal(ceruminousglands),RestingphaseThepaleglycogen-richcellsformsweat（4）eccrineglandssebaceousglandsLength(1000~1500mm)=0.vermilionborderofthelip(Fordyce'sspots)Langerhanscells(CD1a)MetabolismIncreasedsweatproductioninresponsetoheatispartofthethermoregulatorysystemofthebody;togetherwithincreasedcutaneousbloodflow,itcaneffectivelydissipateexcessivebodyheat.Theyaredistributedthroughoutallskinsitesexceptthepalmsandsoles.elasticfiberssecretionandexcretion（4）eccrineglandsdecapitationsecretion992.Dermiscollagenfiberreticularfiberelasticfibersbasematerial（groundsubstance）：proteoglycanCells:FibroblastmastcellMacrophagedermicarborescentcellLanggerhanscellPigmentophageLymphocyteleukocyteBefoundingreatestabundance1002.Dermiscollagenfibers282.Dermiscollagenfibersthefemaleareolas(Montgomery'stubercles).Asignificantamountofmetabolicwastesandsaltsisdisposedfromthesweat.Thepa