CONNECTIVETISSUEPROPERCONNECTIVETISSUEPROPERGeneralhistologyIntroduction&CellTissueEpitheliumConnectivetissueConnectivetissueproperCartilage&boneBloodMuscletissueNervetissueSpecialhistologyOrgan&systemThecirculatorysystemTheimmunesystemTherespiratorysystemDigestivetractDigestiveglandsTheendocrinesystemTheurinarysystemThemalereproductivesystemThefemalereproductivesystemGeneralhistologyIntroduction（固有結(jié)締組織）INTRODUCTIONConnectiveTissue(CT)GeneralFeaturesFewercells,moreextracellularmatrixNopolarityRichinbloodvesslesFunctions:connection,support,protection,INTRODUCTIONConnectiveTissueINTRODUCTIONCToriginatesfromthemesenchyme,anembryonictissueformedbymesenchymalcellsandamorphousmatrix無定形基質(zhì).MesenchymalcellINTRODUCTIONCToriginatesfromINTRODUCTIONCT（inwidesense）CTproper（innarrowsense）CartilageBoneBloodLooseCTDenseCTAdiposetissueReticulartissueINTRODUCTIONCTCTproperCartilaLOOSECONNECTIVETISSUELooseConnectiveTissue(LCT)–Areolar蜂窩TissueFeatures:moretypesofcellsandfewerfibersLOOSECONNECTIVETISSUELooseCLOOSECONNECTIVETISSUELooseConnectiveTissueconsistsofCells:fibroblast成纖維細胞,plasmacell漿細胞,macrophage巨噬細胞,mastcell肥大細胞,fatcell,undifferentiatedmesenchymalcell,leukocyte['l?k?,sa?t]白細胞.ExtracellularmatrixFiber:collagenousfiber,elasticfiber,reticularfiberGroundsubstanceLOOSECONNECTIVETISSUELooseCLCTCELLCell:建：undifferentiatedmesenchymalcell成：fibroblast巨：macrophage大：mastcell白：leukocyte漿：plasmacell肪：fatcellLCTCELLCell:DescribethestructureofacellLMShapeNucleus細胞核:nucleolus核仁Cytoplasm細胞質(zhì)EMOrganelles[,??g?'nel細胞器Granules[gr?nju:ls]顆粒DescribethestructureofaceFibroblastThemostcommoncellsinLCTLM:

FlatwithprocessesNucleus:large,palestained著色淺,withprominentnucleolus核仁明顯Cytoplasm:slightlybasophilic[,bes?‘f?l?k嗜堿性EM:richinrER,freeribosomes'ra?b?som]andGol.FUNCTION:synthesizefibersandmatrixLCTCELLFIBROBLASTFibroblastLCTCELLFIBROBFibroblast(HE)Fibroblast(HE)LCTCELLFIBROBLASTFibroblast(TEM)LCTCELLFIBROBLASTFibroblLCTCELLFIBROBLASTFibrocyte:aninactivestatus靜止狀態(tài)offibroblastwhichcandevelopintofibroblastforrepairingFibrocyteFibroblastLCTCELLFIBROBLASTFibrocyLCTCELLPLASMACELLPlasmaCell※※DerivedfromBlymphocyteLM:ovoidorroundinshape.Roundeccentrically-locatednucleuswithwheel-arrangedheterochromatin.Cytoplasmisabundantandintenselybasophilic.EM:richinrER,freeribosomesandGol.Function:synthesizeandsecrete分泌immunoglobulins[,?mj?no‘glɑbj?l?n](antibodies),takingpartinhumoralimmunity[?'mju?n?t?]體液免疫.LCTCELLPLASMACELLPlasma（固有結(jié)締組織）（固有結(jié)締組織）（固有結(jié)締組織）PlasmaCell（TEM）PlasmaCell（TEM）Macrophage巨噬DerivedfrommonocyteinbloodLM：Shape:irregularwithshortprocessesNucleus:small,darklystainedCytoplasm:acidophilic,withgranules巨噬顆粒ofvarioussizesEM:numerousmicrovilli,richinlysosomes,phagosomes,phagocyticvacuoleandresidualbodyFunction:Chemotaxis；Phagocytosis吞噬作用Secretion；ImmunereactionLCTCELLMACROPHAGEMacrophage巨噬LCTCELLMACR20MacrophageHistocyte:macrophageinLCTMacrophageHistocyte:macrophag

Macrophage(TEM)Macrophage(TEM)MacrophageMacrophageMacrophageMacrophageMastCellDistributedaroundvesselsStructure:

Large,roundorovoidNucleus:smallandpale-stainedCytoplasm:filledwithnumerouscoarsemetachromatic易染性granules.Function:thegranulescontainheparin肝素,histamine組胺andeosinophilchemotacticfactors嗜酸性趨化因子,andthecytoplasmcontainsleukotriene白三烯,takingpartinallergicreactions過敏發(fā)應.LCTCELLMASTCELLMastCellLCTCELLMASTCELMastCellMastCellMastCell(TEM)MastCell(TEM)LCTCELLFATCELLFatCell(Adipocyte)StructureLarge,roundorpolygonalEccentric,flattenednucleusAthinrimofcytoplasmAlargelipiddropletFunction:synthesizeandstorefatLCTCELLFATCELLFatCellWhiteadiposetissueHEWhiteadiposetissueHELCTCELLUndifferentiatedMesenchymalCellStructure:similartofibrocyteFunction:withdifferentiatingpotentialLeukocytesNeutrophil,eosinophilandlymphocyteLCTCELLUndifferentiatedMesLCTFIBERFiber:synthesizedbyfibroblastCollagenous[k?'l?d??n?s]fiber膠原纖維ElasticfiberReticularfiberLCTFIBERFiber:synthesizedLCTFIBERCOLLAGENOUSFIBERCollagenous[k?'l?d??n?s]Fiber(Whitefiber)LM:Thick、AcidophilicEM:parallel-arrangedcollagenousfibrils膠原原纖維Collagenousfibril:Withperiodiccrossstriation周期性橫紋at64nmintervalComponent成分:typeⅠandⅢcollagens

MechanicalProperty:greattensilestrengthLCTFIBERCOLLAGENOUSFIBECollagenousFiberElasticFiberCollagenousFiberElasticFiberCollagenousFiber（MuscleTendonHE）CollagenousFiber（MuscleTendoCollagenousFibril(EM)CollagenousFibril(EM)LCTFIBERELASTICFIBERElasticFiber(yellowfiber)LM:ThinSlightred(HE),purple(aldehydefuchsin)orbrown(orcein)EM:Elastin+MicrofibrilMechanicalProperty:greatelasticityLCTFIBERELASTICFIBERElaMolecularbasisofelasticity

MolecularbasisofelasticityCollagenousFiberElasticFiberCollagenousFiberElasticFiberLargeArteryLargeArteryLCTFIBERRETICULARFIBERReticularFiberLM:Thin；BranchtoformnetworksArgyrophilfiber(silverstaining)；PAS(+)EM:Component:typeⅢcollagen64nmcrossstriationsDistribution:ReticulartissueConnectingportion,e.g.reticularlaminaLCTFIBERRETICULARFIBERRReticularFiber

←（LymphNode，silverstaining

）←←ReticularFiber←←←LCTGROUNDSUBSTANCEGroundSubstanceAmorphouscolloidalsubstanceConsistsofGlycosaminoglycan糖胺多糖Proteoglycan蛋白多糖Multiadhesiveglycoprotein多黏多糖Tissuefluid組織液LCTGROUNDSUBSTANCEGroundSLCTGROUNDSUBSTANCEGLYCOSAMINOGLYCANGlycosaminoglycans(GAGs)SulfatedChondroitinsulfateA,C硫酸軟骨素Keratansulfate硫酸角質(zhì)素Heparansulfate硫酸乙酰肝素Dermatansulfate硫酸皮膚素NonsulfatedHyaluronicacid(hyaluronan)透明質(zhì)酸LCTGROUNDSUBSTANCEGLYCOLCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanA.Proteoglycansubunit1Coreprotein4GAGsTesttubebrushlikeCoreproteinGAGsLCTGROUNDSUBSTANCEPROTELCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanB.ProteoglycanaggregateCoreproteinHyaluronicacid透明質(zhì)酸ProteoglycansubunitLinkprotein連接蛋白LCTGROUNDSUBSTANCEPROTEProteoglycansubunitCollagenousfibrilMolecularsieveProteoglycansubunitCollagenouLCTGROUNDSUBSTANCE

MULTIADHESIVEGLYCOPROTEINMultiadhesiveGlycoprotein多黏多糖Fibronectin,FN纖維粘連蛋白Laminin,LN層粘連蛋白Chondronectin,ChN軟骨粘連蛋白LCTGROUNDSUBSTANCE

MULTLCTGROUNDSUBSTANCETISSUEFLUIDTissueFluidLCTGROUNDSUBSTANCETISSUDENSECONNECTIVETISSUEDenseConnectiveTissue(DCT)Features:fewercells,morefibersFunction:connectionandsupportingThreetypesDenseregularconnectivetissueDenseirregularconnectivetissueElastictissue※※DistributionDENSECONNECTIVETISSUEDenseCDCTDENSEREGULARCONNECTIVETISSUEDenseregularconnectivetissueStructure:Parallel-arrangedcollagenousfibersTendoncells:specialfibroblastwithwing-likeprocessesDistribution:TendonsLigamentsDCTDENSEREGULARCONNECTIVEDenseregularconnectivetissue,H&ETC:nucleioftendoncellDenseregularconnectivetissuDCTDENSEIRREGULARCONNECTIVETISSUEDenseirregularconnectivetissueStructureFibersarearrangedinbundleswithoutadefiniteorientation.FibroblastLessgroundsubstanceDistribution:dermis,scleraandcapsuleofsomeorgansDCTDENSEIRREGULARCONNECTIDenseirregularconnectivetissue(dermis)H&EDenseirregularconnectivetisDCTELASTICTISSUEElastictissueElasticfibersarearrangedinbundlesorformamembraneDistribution:nuchalligament,ligamentumflavumandlargearteryLargearteryDCTELASTICTISSUEElastictiADIPOSETISSUEAdiposetissueComposedoffatcells,separatedbyLCT2types:WhiteadiposetissueBrownadiposetissueADIPOSETISSUEAdiposetissueADIPOSETISSUEWhiteadiposetissueDistribution:subcutaneoustissueUnilocularfatcell:alargelipiddroplet,eccentric,flattenednucleus,arimofcytoplasmFunction:energystorageADIPOSETISSUEWhiteadiposetiWhiteadiposetissueHEWhiteadiposetissueHEADIPOSETISSUEBrownadiposetissueDistribution:newbornandhibernatinganimalsMultilocularfatcell:numerouslipiddroplet,roundnucleusinthecenterFunction:Heatproduction(thermogenesis)ADIPOSETISSUEBrownadiposetiADIPOSETISSUEADIPOSETISSUERETICULARTISSUEReticulartissueDistribution:hemopoietictissueandlymphatictissueReticularcell：Reticularfiber:GroundsubstanceProvideflexiblesupportandpredominatesinthevertebralcolumn’sligamentaflavaandthesuspensoryligmengofthepenis.RETICULARTISSUEReticulartissSchematicdiagramofreticulartissueMacrophageLymphocyteReticularfiberReticularcellSchematicdiagramofreticularReticulartissue(lymphnode)silverstaining1reticularcell2reticularfiber3lymphocyteReticulartissue(lymphnode)同步練習一、填空1.漿細胞超微結(jié)構(gòu)特點是，細胞質(zhì)內(nèi)含有大量____________和____________,發(fā)達的_______________。2．巨噬細胞的功能主要是_____________、_______________和____________。粗面內(nèi)質(zhì)網(wǎng)游離核糖體高爾基復合體吞噬作用抗原提呈作用分泌功能同步練習一、填空粗面內(nèi)質(zhì)網(wǎng)游離核糖體高爾基復合體吞噬作用抗原同步練習一、填空3．成纖維細胞具有產(chǎn)生_______和________的功能。當成纖維細胞功能處于靜止狀態(tài)時稱______細胞。4.肥大細胞釋放的_________和_________可使細支氣管平滑肌收縮及毛細血管擴張,________具有抗凝血作用。

纖維纖維基質(zhì)組胺白三烯肝素同步練習一、填空纖維纖維基質(zhì)組胺白三烯肝素同步練習二、單項選擇1．巨噬細胞的前身是（）A.間充質(zhì)細胞B.網(wǎng)狀細胞C.內(nèi)皮細胞D.單核細胞E.淋巴細胞2.疏松結(jié)締組織中具有吞噬作用的細胞是()A.成纖維細胞B.巨噬細胞C.漿細胞D.肥大細胞E.脂肪細胞DB同步練習二、單項選擇DB同步練習二、單項選擇3.關(guān)于漿細胞的描述，哪一項是錯誤的()A.胞質(zhì)嗜堿性B.細胞核常偏位C.核旁有一淺染區(qū)D.參與細胞免疫E.粗面內(nèi)質(zhì)網(wǎng)豐富

4．成纖維細胞的電鏡結(jié)構(gòu)特點是()A.有大量的溶酶體B.有大量的脂滴C.有豐富的線粒體D.有膜包顆粒E.有豐富的粗面內(nèi)質(zhì)網(wǎng)、游離核糖體和發(fā)達的高爾基復合體

DE同步練習二、單項選擇DE同步練習三、判斷1. 成纖維細胞和纖維細胞是處于不同功能狀態(tài)的同一種細胞，能相互轉(zhuǎn)化。2. 結(jié)締組織中的成纖維細胞和網(wǎng)狀細胞均可產(chǎn)生纖維。漿細胞的功能是合成和分泌免疫球蛋白(抗體)。4．漿細胞卵圓形,核圓偏居細胞一側(cè),胞質(zhì)嗜酸性,電鏡下可見大量平行排列的粗面內(nèi)質(zhì)網(wǎng)和發(fā)達的高爾基復合體。

正確正確正確錯誤同步練習三、判斷正確正確正確錯誤CONNECTIVETISSUEPROPERCONNECTIVETISSUEPROPERGeneralhistologyIntroduction&CellTissueEpitheliumConnectivetissueConnectivetissueproperCartilage&boneBloodMuscletissueNervetissueSpecialhistologyOrgan&systemThecirculatorysystemTheimmunesystemTherespiratorysystemDigestivetractDigestiveglandsTheendocrinesystemTheurinarysystemThemalereproductivesystemThefemalereproductivesystemGeneralhistologyIntroduction（固有結(jié)締組織）INTRODUCTIONConnectiveTissue(CT)GeneralFeaturesFewercells,moreextracellularmatrixNopolarityRichinbloodvesslesFunctions:connection,support,protection,INTRODUCTIONConnectiveTissueINTRODUCTIONCToriginatesfromthemesenchyme,anembryonictissueformedbymesenchymalcellsandamorphousmatrix無定形基質(zhì).MesenchymalcellINTRODUCTIONCToriginatesfromINTRODUCTIONCT（inwidesense）CTproper（innarrowsense）CartilageBoneBloodLooseCTDenseCTAdiposetissueReticulartissueINTRODUCTIONCTCTproperCartilaLOOSECONNECTIVETISSUELooseConnectiveTissue(LCT)–Areolar蜂窩TissueFeatures:moretypesofcellsandfewerfibersLOOSECONNECTIVETISSUELooseCLOOSECONNECTIVETISSUELooseConnectiveTissueconsistsofCells:fibroblast成纖維細胞,plasmacell漿細胞,macrophage巨噬細胞,mastcell肥大細胞,fatcell,undifferentiatedmesenchymalcell,leukocyte['l?k?,sa?t]白細胞.ExtracellularmatrixFiber:collagenousfiber,elasticfiber,reticularfiberGroundsubstanceLOOSECONNECTIVETISSUELooseCLCTCELLCell:建：undifferentiatedmesenchymalcell成：fibroblast巨：macrophage大：mastcell白：leukocyte漿：plasmacell肪：fatcellLCTCELLCell:DescribethestructureofacellLMShapeNucleus細胞核:nucleolus核仁Cytoplasm細胞質(zhì)EMOrganelles[,??g?'nel細胞器Granules[gr?nju:ls]顆粒DescribethestructureofaceFibroblastThemostcommoncellsinLCTLM:

FlatwithprocessesNucleus:large,palestained著色淺,withprominentnucleolus核仁明顯Cytoplasm:slightlybasophilic[,bes?‘f?l?k嗜堿性EM:richinrER,freeribosomes'ra?b?som]andGol.FUNCTION:synthesizefibersandmatrixLCTCELLFIBROBLASTFibroblastLCTCELLFIBROBFibroblast(HE)Fibroblast(HE)LCTCELLFIBROBLASTFibroblast(TEM)LCTCELLFIBROBLASTFibroblLCTCELLFIBROBLASTFibrocyte:aninactivestatus靜止狀態(tài)offibroblastwhichcandevelopintofibroblastforrepairingFibrocyteFibroblastLCTCELLFIBROBLASTFibrocyLCTCELLPLASMACELLPlasmaCell※※DerivedfromBlymphocyteLM:ovoidorroundinshape.Roundeccentrically-locatednucleuswithwheel-arrangedheterochromatin.Cytoplasmisabundantandintenselybasophilic.EM:richinrER,freeribosomesandGol.Function:synthesizeandsecrete分泌immunoglobulins[,?mj?no‘glɑbj?l?n](antibodies),takingpartinhumoralimmunity[?'mju?n?t?]體液免疫.LCTCELLPLASMACELLPlasma（固有結(jié)締組織）（固有結(jié)締組織）（固有結(jié)締組織）PlasmaCell（TEM）PlasmaCell（TEM）Macrophage巨噬DerivedfrommonocyteinbloodLM：Shape:irregularwithshortprocessesNucleus:small,darklystainedCytoplasm:acidophilic,withgranules巨噬顆粒ofvarioussizesEM:numerousmicrovilli,richinlysosomes,phagosomes,phagocyticvacuoleandresidualbodyFunction:Chemotaxis；Phagocytosis吞噬作用Secretion；ImmunereactionLCTCELLMACROPHAGEMacrophage巨噬LCTCELLMACR87MacrophageHistocyte:macrophageinLCTMacrophageHistocyte:macrophag

Macrophage(TEM)Macrophage(TEM)MacrophageMacrophageMacrophageMacrophageMastCellDistributedaroundvesselsStructure:

Large,roundorovoidNucleus:smallandpale-stainedCytoplasm:filledwithnumerouscoarsemetachromatic易染性granules.Function:thegranulescontainheparin肝素,histamine組胺andeosinophilchemotacticfactors嗜酸性趨化因子,andthecytoplasmcontainsleukotriene白三烯,takingpartinallergicreactions過敏發(fā)應.LCTCELLMASTCELLMastCellLCTCELLMASTCELMastCellMastCellMastCell(TEM)MastCell(TEM)LCTCELLFATCELLFatCell(Adipocyte)StructureLarge,roundorpolygonalEccentric,flattenednucleusAthinrimofcytoplasmAlargelipiddropletFunction:synthesizeandstorefatLCTCELLFATCELLFatCellWhiteadiposetissueHEWhiteadiposetissueHELCTCELLUndifferentiatedMesenchymalCellStructure:similartofibrocyteFunction:withdifferentiatingpotentialLeukocytesNeutrophil,eosinophilandlymphocyteLCTCELLUndifferentiatedMesLCTFIBERFiber:synthesizedbyfibroblastCollagenous[k?'l?d??n?s]fiber膠原纖維ElasticfiberReticularfiberLCTFIBERFiber:synthesizedLCTFIBERCOLLAGENOUSFIBERCollagenous[k?'l?d??n?s]Fiber(Whitefiber)LM:Thick、AcidophilicEM:parallel-arrangedcollagenousfibrils膠原原纖維Collagenousfibril:Withperiodiccrossstriation周期性橫紋at64nmintervalComponent成分:typeⅠandⅢcollagens

MechanicalProperty:greattensilestrengthLCTFIBERCOLLAGENOUSFIBECollagenousFiberElasticFiberCollagenousFiberElasticFiberCollagenousFiber（MuscleTendonHE）CollagenousFiber（MuscleTendoCollagenousFibril(EM)CollagenousFibril(EM)LCTFIBERELASTICFIBERElasticFiber(yellowfiber)LM:ThinSlightred(HE),purple(aldehydefuchsin)orbrown(orcein)EM:Elastin+MicrofibrilMechanicalProperty:greatelasticityLCTFIBERELASTICFIBERElaMolecularbasisofelasticity

MolecularbasisofelasticityCollagenousFiberElasticFiberCollagenousFiberElasticFiberLargeArteryLargeArteryLCTFIBERRETICULARFIBERReticularFiberLM:Thin；BranchtoformnetworksArgyrophilfiber(silverstaining)；PAS(+)EM:Component:typeⅢcollagen64nmcrossstriationsDistribution:ReticulartissueConnectingportion,e.g.reticularlaminaLCTFIBERRETICULARFIBERRReticularFiber

←（LymphNode，silverstaining

）←←ReticularFiber←←←LCTGROUNDSUBSTANCEGroundSubstanceAmorphouscolloidalsubstanceConsistsofGlycosaminoglycan糖胺多糖Proteoglycan蛋白多糖Multiadhesiveglycoprotein多黏多糖Tissuefluid組織液LCTGROUNDSUBSTANCEGroundSLCTGROUNDSUBSTANCEGLYCOSAMINOGLYCANGlycosaminoglycans(GAGs)SulfatedChondroitinsulfateA,C硫酸軟骨素Keratansulfate硫酸角質(zhì)素Heparansulfate硫酸乙酰肝素Dermatansulfate硫酸皮膚素NonsulfatedHyaluronicacid(hyaluronan)透明質(zhì)酸LCTGROUNDSUBSTANCEGLYCOLCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanA.Proteoglycansubunit1Coreprotein4GAGsTesttubebrushlikeCoreproteinGAGsLCTGROUNDSUBSTANCEPROTELCTGROUNDSUBSTANCEPROTEOGLYCANProteoglycanB.ProteoglycanaggregateCoreproteinHyaluronicacid透明質(zhì)酸ProteoglycansubunitLinkprotein連接蛋白LCTGROUNDSUBSTANCEPROTEProteoglycansubunitCollagenousfibrilMolecularsieveProteoglycansubunitCollagenouLCTGROUNDSUBSTANCE

MULTIADHESIVEGLYCOPROTEINMultiadhesiveGlycoprotein多黏多糖Fibronectin,FN纖維粘連蛋白Laminin,LN層粘連蛋白Chondronectin,ChN軟骨粘連蛋白LCTGROUNDSUBSTANCE

MULTLCTGROUNDSUBSTANCETISSUEFLUIDTissueFluidLCTGROUNDSUBSTANCETISSUDENSECONNECTIVETISSUEDenseConnectiveTissue(DCT)Features:fewercells,morefibersFunction:connectionandsupportingThreetypesDenseregularconnectivetissueDenseirregularconnectivetissueElastictissue※※DistributionDENSECONNECTIVETISSUEDenseCDCTDENSEREGULARCONNECTIVETISSUEDenseregularconnectivetissueStructure:Parallel-arrangedcollagenousfibersTendoncells:specialfibroblastwithwing-likeprocessesDistribution:TendonsLigamentsDCTDENSEREGULARCONNECTIVEDenseregularconnectivetissue,H&ETC:nucleioftendoncellDenseregularconnectivetissuDCTDENSEIRREGULARCONNECTIVETISSUEDenseirregularconnectivetissueStructureFibersarearrangedinbundleswithoutadefiniteorientation.FibroblastLessgroundsubstanceDistribution:dermis,scleraandcapsuleofsomeorgansDCTDENSEIRREGULARCONNECTIDenseirregularconnectivetissue(dermis)H&EDenseirregularconnectivetisDCTELASTICTISSUEElastictissueElasticfibersarearrangedinbundlesorformamembraneDistribution:nuchalligament,ligamentumflavumandlargearteryLargearteryDCTELASTICTISSUEElastictiADIPOSETISSUEAdiposetissueComposedoffatcells,separatedbyLCT2types:WhiteadiposetissueBrownadiposetissueADIPOSETISSUEAdiposetissueADIPOSETISSUEWhiteadiposetissueDistribution:subcutaneoustissueUnilo