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2022年四川省綿陽市大學英語6級大學英語六級測試卷(含答案)學校:________班級:________姓名:________考號:________
一、2.ReadingComprehension(SkimmingandScanning)(20題)1.
OneoftheeducationalactivitiesinEastHarlemHealthyHeartProgramis______.
2.
One-ortwo-minuteexcerpts______,canbesenttofriendsbye-mailorinstantmessage.
3.
Toitsadvocates,constructivistmath______,buildscriticalthinkingandrescuesclassesfromnumbingrepetition.
4.
______asthe"covertdepression",ithasthreemajorsymptoms.
5.
Afteryouhavebeencyclingforafewmonths,theauthorthinksthatyouwillfindcyclingintownslessdangerous.
A.YB.NC.NG
6.Theelectrostaticprecipitatorhasgotridof______frommanufacturingprocesses.
A.severeemissions
B.ozone-layerdepletion
C.manypollutants
D.toxicsubstances
7.JudgingfromDukeUniversity'srecentstudy,evenstudentsrecruitedbytopcollegesseemtohave______before.
8.
WelearnfromthepassagethatconditionsfortheearlywhitestravelingtoAmericabyshipsweremuchbetterthan
9.
ComparedwiththenumberofAmericanpeoplewhohadtheirbloodcholesterollevelscheckedin1990was____________________thanthatofin1983.
10.
Criminalprofilesjustifythepolicescathesandarrestswithoutwarrants,apracticesupportedby______.
11.Whendohighheadpowerplantsusesurpluselectricitytotransferwatertoasecondreservoir?
A.Inthemorning.B.Atnoon.C.Intheafternoon.D.Atnight.
12.
Accordingtothepassage,tubewormsliveon______.
13.
Sofar,thereseemstobenosolutioninsightastohowthehydrogencanbestored.
A.YB.NC.NG
14.
Bobdidn'tunderstandwhytheEnglishbusinessmen______overlunch.
15.
Whenpeoplegossipaboutothers,theyusuallycomparethemselvestothegossipedones,andthinkthemselves______.
16.
TwoopposingcampshavedifferentideasabouthowtorespondtoIran'sdecisiontorestart______.
17.
Theschoolwhichblamesglobalizationthinks______.
A.tradeinfluencesmiddlingwagespositively
B.thelabormarketbecomesmoredense
C.technologydecreasesworkers'wagesatonce
D.thereasonofcapital'srewardsoutpacingthoseoflaborisuncertain
18.NewHopesforPreventingAIDS
Thesuccessofanti-retroviral(抑止腫瘤病毒)drugsintreatingHIVisgettingresearchersatthe16thInternationalAIDSconferenceexcitedattheprospectthatthepotent(效力大的)medicinesmightbeexploitedtoperform.doubleduty.WhynotusethepoweroftheseARVstopreventanHIVtransmissionorinfectionfromtakingholdinthefirstplace?BillandMelindaGatesaskedthatprovocativequestionontheopeningdayoftheconference,andarecommit-tingtheirconsiderablefinancialresourcestowardfindingananswer.Intheirremarks,theyhighlightedtheneedtodevelopmicrobicides(殺菌劑)andoralpreventiondrugswhilewewaitforavaccine.AndtheywillgettheirfirsthintathowsmarttheirdecisionwasthisThursday,whenscientistsfromWestAfricareporttheinitialresultsfromthefirsttrialstudyinganoralpreventiondrug.
SohowrealisticaretheGatesinexpectingevenmorefromtheARVs?"Idothinktherangeofpreventionoptionswehavewithinthenextdecadewillgreatlyexpand,"saysDr.HeleneGayle,PresidentofCareUSAandco-chairoftheconference."Thebiologicplausibility(似乎有理)forbothmicrobicidesandoralpreventiondrugsissogreat."Dr.MarkDybul,U.S.GlobalAIDSCoordinator,saidthatifamicrobicideorpreventiondrugbecomesavailabletoprotectpeoplefrominfections,theywouldbefundedunderthePresident'sEmergencyPlanforAIDSReliefifcountrieschosetousethem."Wewouldsupportallofthat;itwouldbeperfectlywithinourmandatetodoallthat,"hetoldTIME.
PreventingHIVistheonlywaytokeepthenumberofnewinfectionsthatoccureachyear—4million—fromgrowing.Andyetpreventionstrategies,alwaystheuglystepsistertotreatmentprograms,havenotreallytakenholdinthedevelopingnationswheretherateofinfectionishighest.Aneffectivevaccine,ofcourse,istheultimatepreventionweapon,butastheGates'pointedout,anHIVshotisstillalongwayoff.Inthemeantime,microbicidescouldbeone
waytoco-optARVsintothepreventionwar;thesearechemicalcompounds,usuallyintheform.ofagelorcream,thatwomencanusevaginallypriortointercoursetostopthetransmissionofHIV—it'sthesameideabehindspermicides(殺精子劑),whicharechemicalbarrierstospermenteringthevaginaandcausingpregnancy.It'sanelegantlysimpleapproach,madeevensimplerbythefactthatresearchersdidn'treallyhavetostartfromscratchtocomeupwithnewanti-HIVcompounds;theyalreadyhavethemintheARVs,whichnowinterruptthevirusfrominfectingcellsatvariouspointsinitslifecycle.
Thekeydifferenceisthatinamicrobicide,thedrugsarebeingusedinhealthypeopleratherthaninthoseinfectedwithHIV.WhenARVsareusedfortreatment,bothdoctorsandpatientsarewillingtotolerateahigherlevelofsideeffects—afterall,ifthechoiceisbetweendyingfromHIV-AIDSandsideeffects,mostpatientsoptforthelatter.Ifthedrugsaretobeusedtopreventinfection,however,everythingchanges;understandably,healthypeoplearen'taslikelytoacceptthesamelevelofsideeffectsandtoxicitiesasthosealreadyinfected.
That'swhyclinicaltrialsaresosignificant.Sofar,thereare30—40differentmicrobicidecandidatesbeingtestedinanimals,andfivetrialsinGhana,Nigeriaandotherdevelopingnationsatthemostadvancedstagesoftestinginwomen.Dr.GitaRamjee,oftheHIVPreventionResearchUnitinDurban,SouthAfrica,hasworkedwithallfive,andishopefulthattheywillproveeffectiveandmakeanimpactonthedisease.BecausetheselatestmicrobicidesarereformulatedARVs,however,theproblemofthevirusbecomingresistanttothemisapotentialdrawback.Dr.PeterPiot,ofUNAIDS,suggestsbasingmicrobicidesonlyonthedrugsdonotmakeitthroughthepharmaceuticalpipeline—manyarerejectedbecaus
A.YB.NC.NG
19.
Researchersassumedthatself-drivingcarsmaybeathreatto______.
A.thetransportationindustry
B.oursafetyontheroad
C.vehicleproduction
D.ouremployment
20.NearlyeveryonehasrealizedthatMicrosoftbuyingHotmailhasillustratedtheparadoxofInternet.
二、3.ListeningComprehension(20題)21.(31)
A.Howmanyweeksthereareinamonth.
B.Whichdayspeopleshouldwork.
C.Howtheweekisdividedintodays.
D.Whichdaybeginstheweek.
22.(27)
A.Personwhoisaneffectiveleaderofaparticulargroupmaynotbeaneffectiveleaderinanothergroup.
B.Fewpeoplesucceedinsharingaleadershiprolewithanotherperson.
C.Apersoncanbestlearnhowtobeaneffectiveleaderbystudyingresearchonleadership.
D.Mostpeopledesiretobeleadersbutcanproducelittleevidenceoftheirqualifications.
23.(25)
A.Decaffeinatedcoffeemayhelppreventheartdisease.
B.Coffeedoesnotnecessarilycauseheartdisease.
C.Coffeehaslesscaffeinethansoda.
D.Caffeinecanbeusedasheadacheremedy.
24.
【B4】
25.(36)
A.Shecommunicatedherideasveryeffectively.
B.Shemadeexcellentpoliticalachievements.
C.Shehadahusbandseverelyinjuredinanincident.
D.Shehaddifferentpoliticalopinions.
26.(26)
A.Writetheirlabreport.
B.FindoutProfessorSmith'sschedule.
C.Interviewsomehighschoolstudents.
D.Finishtheirchemistryexperiment.
27.(21)
A.He'llplayforthematchinhonourofhim.
B.He'lltakehiswifeandhischildrenoutfordinner.
C.He'llcelebrateitwithhisfriends.
D.He'llwintheLeagueCupthatdayforcelebration.
28.聽力原文:Inthiscentury,photographshavebeenreallyimportantforteachingarthistory.IwillshowwhatImeaninamomentwithsomephotographstakenbyPeterandPaulJulie.TheworkofthesetwophotographershasbeenaveryusefulsourceforstudyingtheartproducedintheUnitedStatesfrom1896tothepresent.PeterandPaulJuliewerenotartists,buttheywerearegularpartofNewYorkartscene.Theytookoverahundredthousandphotographswhichdocumentthelifeandworkofthousandsofartists.PeterJulieisknownaspioneerinthisfieldofartphotography.GeorgeOrkieveandotherfamousartistssoughthimouttotakepicturesoftheirwork.Hisspecialtywasphotographingpainting.HissonPaulphotographssculptures.Someoftheirmostimportantphotosaretheonesofworksofartthathavesincebeendestroyed.Oneexampleisaphotothatwe'lllookattoday.Wouldsomeonegetthelightplease?Thanks.ThisslideisfromaphotographofpaintingbyEdvordHarborcalledComBeltCity.Thepaintingwasexhibitedonlytwoorthreetimesbeforeitwasdestroyedinthefire.WithouttheJuliesphotograph,novisualrecordoftheworkwouldexist.AlthoughtheJuliesmostlyphotographedtheworksofpaintersandseulptors,theyalsooccasionallyphotographedarchitecturalsubjects.TheydidquiteafewphotosofthebuildingsbyJohnMuisopope.Andwe'regoingtolookatoneofthosenext.
(33)
A.Apainterandasculptor.
B.Paintingsinspiredbyphotographs.
C.Earlyphotographictechniques.
D.Theworkoftwophotographers.
29.(24)
A.ShewenttoSafariPark.
B.ShewenttoOxford.
C.Shewatchedthesunrise.
D.ShewenttoStonehenge.
30.聽力原文:WhentheWestinghouseScienceTalentSearchTeamnameditstopachieversin1983,thegrandprizewenttoPaulNing,then16.
PaulNingisnotanative-bornAmerican.HeisthesonofaprofessorfromthePeople'sRepublicofChina.NingcametotheUnitedStatesattheageofthree.By11,hewasconstructingasimplewindtunneltostudytherelationshipbetweenspeedandpressure.NowbeingasenioratthesuperbBronxHighSchoolofScienceinNewYorkCity,Ningfeels:"Youhavetobeaggressiveinyourstudiestoreallyunderstandwhatyou'redoing."Hismotheradds:"Healwaystriestoprovetousandtohimselfthatheisthebest."
Outof40Westinghousefinalists,nine,includingNing,wereborninAsiaandthreeotherswereofAsiandescent.Thisstoryhasremindedusofthefactthatsome10%ofHarvardUniversity'sfreshmanclassisAsian-American.Whilenomorethan15%ofCaliforniahighschoolgraduatesareeligibleforadmissiontotheUniversityofCaliforniasystem,about40%ofAsian-Americanqualify.
MosteducatorsbelievethatAsianscholasticachievementhasmuchtodowithbreedingandnurture.ManyAsian-Americanchildrenhavealsowell-educatedparentswhoarealwaysontheschool'sside.Inaddition,mostAsiansregardeducationasthebestwaytorecognitionandsuccessthroughwhichtheypaytheindefinitedebttoparents.Also,thisisawayofshowingfilialduty.Asaresult,itisnowonderthatAsian-Americanchildrenusuallydoafarbetterjobthantheirclassmates.
(30)
A.NewYorkCity.
B.SomewhereintheUnitedStates
C.SomewhereotherthantheUnitedStates.
D.SomewhereotherthanAsia.
31.聽力原文:M:IwassorrytohearaboutBill'sbeingfired.Iknowhewassickalotandthatheusuallygottoworklate.
W:Oh,itwasn'tthat.Billmadeabigerrorinlastmonth'saccounting.Eventhoughitwasn'treallyhisfault,hisbusswasveryangry.
Q:WhydidBilllosehisjob?
(15)
A.Hegotangrywithhisboss.
B.Hewasfrequentlysickandabsentfromwork.
C.Hepreparedafinancialreportincorrectly.
D.Healwaysgottoworklate.
32.(32)
A.Agricultureintheindustrializedworld
B.Cultivatedcrops.
C.Theassociationbetweenrosesandhumans.
D.Thediscoveriesofcertaingrasses.
33.SectionB
Directions:Inthissection,youwillhear3shortpassages.Attheendofeachpassage,youwillhearsomequestions.Boththepassageandthequestionswillbespokenonlyonce.Afteryouhearaquestion,youmustchoosethebestanswerfromthefourchoicesmarkedA,B,CandD.
聽力原文:Ourfriend,Nick,whoseEnglishgetsbetterandbetter,declaredsolemnlytheotherdaythathethoughtthattheBritishclimatewaswonderful,buttheBritishweatherwasterrible.HewentontoexplainbypointingoutthattheBritishclimatewasatemperateone."Thismeant,"hesaid,"thatyoucouldalwaysbecertainthattheweatherwouldneverbeextreme,atanyratenotforanylengthoftime,neververyhotandneververycold."HequiterightlypointedoutthattherainfallinBritain,accordingtothestatistics,wasnotveryheavy."Whythen,"heasked,"hastheBritishclimatesuchabadreputation?"Heansweredbysayingitwasbecauseoftheextraordinary,unreliableweather.Therewasnopartoftheyearatwhichyoucouldbecertainthattheweatherwouldbedryorwet,clearordull,hotorcold.AbaddayinJulycouldbeascoldasamilddayinJanuary.Indeedyoucouldfeelcoldatalmostanytimeoftheyear.NickblameddraftyBritishhousesforthis,butagreedyoucouldalsoblamethesmallamountofsunshineandagreatamountofdampness.HeadvisedeverystudentcomingtoBritaintobringanumbrellaandtounderstandthemeaningofthatsplendidword"drizzle".
(27)
A.AnEnglishprofessor.
B.Aforeignstudent.
C.AnEnglishstudent.
D.AnEnglishweatherman.
34.SectionB
Directions:Inthissection,youwillhear3shortpassages.Attheendofeachpassage,youwillhearsomequestions.Boththepassageandthequestionswillbespokenonlyonce.Afteryouhearaquestion,youmustchoosethebestanswerfromthefourchoicesmarkedA,B,CandD.
聽力原文:BuildingteamspiritisalwaysthefocalpointofwhatItrytodoasamanager.Theteamspirit'sveryimportant,butIdon'tbelieveintryingtomotivatetheteamasateam.Itrytomotivatethemasindividuals.SoIdon'tgivethemtalks.Ispeaktotheplayersindividually.AndItrynottoputtoomuchpressureonthem.Ibelieveplayersperform.bestwhentheyarerelaxed.Ifthey'retootense,Icanguaranteetheywon'tplaywell.
Ialsobelieveingivingpeopleautonomy.Ilikeallthepeoplewhoworkformetobeautonomous.Iveryrarelyinterfere.Ifeelpeopleshouldbejudgedontheirresults.Iftheyproveincompetent,thenI'mincompetentifIkeeponemployingthem.
It'slikethatwiththeteam.Igetcriticizedfornotinterferingduringagameandmakingmoresubstitutions.ButIfeelifI'vechosenthoseelevenplayerstogetaresult,thenIshouldleavethemalonetogetonwithit.
IfI'mdroppingaplayerfromtheteam,Idon'tfeelIhavetoexplainittothem.Iftheywanttodiscussit,I'llsay"Comebackandtalkaboutitinacoupleofdays'time".ButIdon'ttrytore-motivatethem.It'suptothemtohavethecharactertofightback.I'magreatbelieverthatalmosteverythingyouachieveinlifeisdowntoyourattitude.IfIhaveaplayerwhoismagnificentlygiftedbuthasastinkingattitude,Iwon'twastemytimeonhim.
(27)
A.Becausehebelievesinmotivatinghisteamasindividuals.
B.Becausehewantstokeephisteamunderpressure.
C.Becausehefeelsitawkwardtogivethemtalks.
D.Becausehethinkshisteamshouldhavethecharactertofightback.
35.(15)
A.Heisintheschoolcanteen.
B.Heisintheparty.
C.HeiswithCarl.
D.Heisnowheretobefound.
36.
【B11】
37.(35)
A.Fewareacceptedbystate-foundeduniversities.
B.Scholarshipsarenotenoughforthem.
C.Theymustpaymorethanout-of-statestudents.
D.Theyarenoteligibleforscholarshipsatstateuniversities.
38.聽力原文:AnewreportsaysthecostofstudiesatpubliccollegesintheUnitedStatesincreasedfourteenpercentthisyear.Thisisthebiggestincreaseintuitioninthirtyyears.Butthestudyalsofoundthattheaveragestudentpaysalotlessthanthepublishedcostsofacollegeeducation,becauseofgrants.AnditpointsoutthatAmericanstudentsreceivedarecordamountoffinancialaidlastyear.
Studentsdonothavetorepaygrants,heform.ofloans.AbouthalfofAmericancollegestudentsreceivegrants.Thismeansthateducationcostsdifferfromstudenttostudent.
ThereportisfromtheCollegeBoard.Thisisanon-profitmembershipgroupofschoolsandothereducationalorganizations.Oneofitsbest-knownjobsistoadministercollegeentrancetests.
TheCollegeBoardsaystuitionattwo-yearpubliccollegesroseatthesamerateasfour-yearschools.
TheCollegeBoardsaystheincreasesweremainlycausedbycutsinstatespendingoneducation.Butacongressmansayscollegeshaveincreasedtheirpricesinbothgoodandbadeconomictimes.JohnBoehnerofOhioischairmanoftheHouseCommitteeonEducationandtheWorkforce.Hesayscollegesdonotwenttotalkabouttheirdecisionstospendmoneytobuildthingslikerock-climbingwalls.
TheCollegeBoardcollectedinformationfromfour-thousandcollegesanduniversities.Itsaystheaveragetotalchargeforstudentswholiveatapubliccollegeintheirstateisten-thousand-six-hundreddollars.Whiletuitionrosefourteenpercentthisyear,housingandothercostsincreasedatalowerrate.
Ataprivatecollege,totalchargesarealmosttwenty-seven-thousanddollars.Thatisanincreaseofaboutsixpercentoverlastyear.
(33)
A.Itisakindofcoststhestudentsshouldpayforstudies.
B.Itisaform.offinancialaidthestudentsdon'thavetopayback.
C.Itisthemoneythatthestudentsgetfromthecolleges.
D.Itisakindofloansthestudentsshouldrepaywhentheyhavejobs.
39.(29)
A.EverythingatStateUniversityhaschangedinthepasttenyears.
B.Althoughthecampuslooksthesame,somethingshavechangedatStateUniversity.
C.Inspiteofthechangesonthecampus,thecommitmentsatStateUniversityarethesame.
D.EverythinghasstayedthesameatStateUniversityduringthepasttenyears.
40.SectionA
Directions:Inthissection,youwillhear8shortconversationsand2longconversations.Attheendofeachconversation,oneormorequestionswillbeaskedaboutwhatwassaid.Boththeconversationandthequestionswillbespokenonlyonce.Aftereachquestiontherewillbeapause.Duringthepause,youmustreadthefourchoicesmarkedA,B,CandD,anddecidewhichisthebestanswer.
聽力原文:M:Icanhardlybreathe.Wouldyoupleaseputyourcigaretteout?
W:I'msorrythatI'mbotheringyou,butthisisthesmokingsection.Whydon'tyouaskthestewardesstochangeyourseat?
Q:Whatdoesthewomanthinkthemanshoulddo?
(12)
A.Askthestewardessforchange.
B.Movetoanotherpartoftheplane.
C.Sitwherethereisabreeze.
D.Extinguishhiscigarette.
三、4.ReadingComprehension(ReadinginDepth)(20題)41.Theauthor'spurposeincitingthosewhoarerepeatedlyunemployedduringatwelve-monthperiodismostprobablytoshowthat______.
A.thereareseveralfactorsthatcausethepaymentoflowwagestosomemembersofthelaborforce
B.unemploymentstatisticscanunderestimatethehardshipresultingfromjoblessness
C.recurrentinadequaciesinthelabormarketcanexistandcausehardshipsforindividualworkers
D.amajorityofthosewhoarejoblessatanytimedoesnotsufferseverehardship
42.
Fromtheverymomentwhenmenapplyforheirfirstjob,theyaretestedconstantlyby______.
43.
ReykjavikinIcelandicmeans"bayofsmoke",canyouguessthemeaningof"smoke"?
44.Itisclearthathumanhistorywillend;theonlymysteryiswhen.Itisalsoclearthatifthetimingislefttonature(or,ifyouprefer,toGod)andhumanshangonuntilthebloodyend,therace'sfinalexitwillbeignoble(不光彩的).Iffuturegenerationsescapethesaurian(蜥蜴類)agonyofextinctionbyawanderingchunkofrockorice,thesun'sunavoidablegrowthtogianthoodwillstillburntheirlastsuccessorstoashes:onlycindersandgasesanddustwillremain.
Farfuturegenerationsmightprolongtheprocessbypostingcoloniesbeyondtheearth'sorbit,butthesewouldbesadoutpostsattheendofthesolarsystem'slongday,clutchingmemoriesofalostplanetandofbillionsofsacrificedsouls.Thedifficulties—fantasticdifficulties—ofinterstellar(星性際的)travelmightbeovercome,butthemightiestofstarshipscoulddonomorethandefertheendoftheworld.Anignobleexistencehoppingfromplanettoplanet—clingingtoeachcloduntilit,initsturn,wasvaporizedorfrozen—mightstillbebearablewereitnotfortheknowledgeofitsfinaluselessness.Intheend,thereisonlydeathbygravityorentropy,thefieryquantum(量子)pitortheheatlessgreysoup.
ThegreatviolinistJaschaHeifetzwasgreatnotleastbecausehequittheconcertstageathispeak,beforetheshowbecamestaleortheaudiencedriftedaway.Toexitgracefullyissublime(美妙的),asHeifetzunderstood.Andonlyonespeciesiscapableofchoosingasimilarlygracefulexit;allothersmarchonlikerobots.Tocalltimeonthehumanracebychoice,notnecessity,wouldbethefinalvictoryofthehumanspiritoveranimalnature,anabsoluteemancipationfromthecommandofDNA.Preciselybecausenootherknownlife-form.coulddoorevenconceivesuchathing,humanitymust.
Sciencehasrevealedonlyoneplaceintheuniversethatishospitabletointelligentlife,andhumansaretheonlyintelligencethat,asfarasisknown,haseverenjoyedtheopportunitytooccupyit.Ifpeopleleftthestageafterareasonablerun,inthefullnessoftimeintelligencecouldevolveagain(dolphin-people?Chimp--people?orchid(蘭花)—people?).Andthen,induecourse,whenthisnewspeciesdeciphered(譯解)humanbooksorreachedthemarkerthatmightbeleftforthemonthewindlessmoon,theywouldknowthatmanendedhisdominionsothattheirsmightbegin.Imagine,then,howtheywillregardus.Itis,farandaway,thegreatestactofgoodnessevercontemplated,theennoblementofawholespecies;anact,almost,ofangels.
Accordingtothepassage,whatmightbehumanbeing'sbestchoiceforthefinalexit?
A.Leavingthetimingtonature.
B.Thesaurian-likeelimination.
C.Beingburnedbythesun'sheat.
D.Anexitdrivenbyman'srationality.
45.
Itisimpliedinthelastparagraphthat______.
A.bullsandbearsarenowworkingforpeople
B.peoplekeepbearsandbullsastheirpets
C.lawshaveputstockmarketsundercontrol
D.peoplecanenjoytheirfriendshipwithbearsandbulls
46.
ItcanbeinferredfromthepassagethatSocialSecurityprivatizationwill______.
A.providehighreturnsforthenewgovernments
B.bestronglyopposedbyWallStreet
C.bringthefutureretireesmorebenefits
D.allowindividualstoinvestinpersonalaccounts
47.
WhatdidRooseveltsayinhisspeechinChicago?
48.SectionA
Directions:Inthissection,thereisashortpassagewith5questionsorincompletestatements.Readthepassagecarefully.Thenanswerthequestionsorcompletethestatementsinthefewestpossiblewords.
Scientistssaytheyhavehighhopesforadrugthatcouldonedayprovideanewform.oftreatmentforH1V-AIDS.Acompound,whichinterfereswithanelusiveproteinusedbytheHIVvirustoinfecthumancells,hasworkedextremelywellinmonkeys,Ifthe.drugproveseffectiveinhumantrials,scientistssay,itcouldbolster(加強)theeffectivenessoftwoexistingAIDSdrugs,particularlyinfightingdrug-resistantstrainsofthevirus.
Researchersatthepharmaceutical(制藥的)companyMerckareveryexcitedaboutanexperimentaldrug,whichhasworkedaswellinmonkeysinfectedwithaprimateversionofthevirusasanyoftheexistinganti-AIDSdrugs.
Itworksbyblockingoneofthreeproteins,orenzymes,theHIVvirususestogainentranceintoandinfecthumanimmunesystemcells.
Inhibitordrugshavebeendevelopedtoblocktwooftheproteins,toslowprogressionofthediseaseafterinfection.Theyhavebecomestandardtherapyasa"cocktail"forpeopleinfectedwithHIV.
Thoseenzymeserereversetranscriptase(轉(zhuǎn)錄酶)andprotease(蛋白酶).Thefirstconvertsthevirus'geneticmaterialintothatofitshostcells.Thesecondchopsuptheresultinglargerproteinsintosmallerpieces,producingsmallerviralparticlesthatinfectnewcells.
Thethirdprongofcellularattackisaproteincalledintegrase(整合酶),whichexpertssayhasbeenhardertoblock.OnceHIVfoolshostcellsbychangingitsgeneticinformationsoitcanenterthem,integraseactslikeacutandpasteoperationinawordprocessor,deletinganimmunecell'sgeneticmaterialandreplacingitwithitsown.
AnintegraseinhibitorwouldgivedoctorsathirdlineofattackagainstHIVinfection,accordingtovirologistDariaHazudaofthedivisionofVirusandCellBiologyatMerck.
"Thiswouldofferathirdclassofanti-retroviralmedicationsthatcanbecombinedwithreversetranscriptaseinhibitorsandproteaseinhibitors.Andsinceitisanewmechanismofaction,thesecompoundsareactiveagainstmulti-drugresistantvariants.SovariantsthatareresistanttoallcurrenttherapieshavebeenselectedinHIV-patients,"shesaid.
Currentanti-AIDSdrugseventuallybecomeresistanttotherapy,orstopworking,becausetheviruschangesitsshape.
Whileresearchersareencouragedbythesuccesswiththecompound'seffectivenessinmonkeytrials,developingadrugthatisequallyeffectiveinhumanscanbedifficult.
StevenYoungisexecutivedirectoroftheDepartmentofMedicinalChemistryatMerck.Hesays,ifscientistsfindacompoundthatisequallyeffectiveinpeople,thecompanywouldaskU.S.regulatorstospeedapprovalofthedrug.
"Yeah,Ireallythinkthat'swhatwe'rehopingfor,"hesaid."Imean,weneedtogetdatathatshowithasrobustanti-viraleffectsinpeople.Andifwe'reabletogetthatdata,Ithinkwewouldpetitionforfasttrackstatus."
Dr.Youngsaysanintegraseinhibitorhasthepotentialtopreventdrugresistance.
"Toensureourbestchancesofpreventingresistance,wewouldgivethisaspartofacocktailtherapy,"headded."AndIthinkit'sreallyourplanthatwewouldtestthiswithreversetranscriptaseinhibitorsandproteaseinhibitors,aswell."
Ifthedrugproveseffectiveinhumantrials,itcouldenhancetheeffectivenessofexistingAIDSdrugsin______.
49.
Accordingtotheauthor,howwouldscientistscommentonmanyofthethingstheyconsiderimportantand
50.
ToknowinglyallowoneselftopursueunhealthyhabitsiscomparedbyFriesandCrapoto______.
51.
Whichofthefollowingstatementsisalwaystrueaccordingtothesurveysmentionedinthepassage?
A.Consumerswillpostponebuyingthingsiftheythinkpriceswilldecrease.
B.Consumerstendtospendtheirmoneyquickiftheythinkthepricewillincrease.
C.Thepricesituationhasaninfluenceonconsumers'behavior.
D.Traditionalassumptionsaboutearnin
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