1、北京保健品會議,2008年4月,內(nèi) 容,Martek介紹 DHA 的定義及主要功效 為什么選擇藻油DHA？ DHA在保健品中的應(yīng)用 Lifes DHA保健品 Lifes DHA在保健品中應(yīng)用,Martek介紹,Martek Biosciences Corporation,1985年成立，總部在美國馬里蘭州(NASDAQ-MATK)上市公司 專注于生物科學研究 具有豐富經(jīng)驗的研究團隊，集中了大批擁有碩士、博士學歷的技術(shù)人員 強大的全球合作網(wǎng)絡(luò) 開發(fā)海洋微藻類高價值產(chǎn)品 主要生產(chǎn) DHA, 品牌為 lifesDHA 配方奶粉 功能性食品 營養(yǎng)品 純植物來源 DHA 擁有足夠資源可持續(xù)供貨,Fish

2、 eat algae (Uncontrolled most abundant in neural, retinal and CV conducting tissue 含在所有組織里，尤其在神經(jīng)、視網(wǎng)膜和心血管組織里含量更高 Brain: 97% of n-3 is DHA 大腦中 97%n-3為DHA Retina: 93% of n-3 is DHA 視網(wǎng)膜中93%n-3 為DHA Facilitates synaptic transmission 協(xié)調(diào)突觸傳遞 Supports myelination 支持髓鞘形成 Influences the speed that information

3、 is acquired and processed 影響獲取、處理信息的速度,Docosahexaenoic Acid - DHA 22:6 3,The Distinct Benefits of Omega-3s,認知能力的 發(fā)展和作用,視覺的發(fā) 展和作用,抗炎功能,心血管功能,維系必需 脂肪酸 的均衡,Retina 視網(wǎng)膜,0,5,10,15,20,25,weight % total fatty acids,n-3,n-6,Brain 大腦,0,5,10,15,20,25,weight % total fatty acids,ALA,EPA,DHA,LA,ARA,Liver 肝,weigh

4、t % total fatty acids,Adipose 結(jié)締組織,0,5,10,15,20,25,weight % total fatty acids,Lauritzen et al (2001) Prog Lipid Res,ALA,EPA,DHA,LA,ARA,ALA,EPA,DHA,LA,ARA,ALA,EPA,DHA,LA,ARA,Only DHA Readily Accumulates in Neural Tissues只有DHA能容易地促進神經(jīng)組織的發(fā)育,DHA is Important Throughout LifeDHA在人體一生中都扮演著重要的作用,Pregnancy孕期

5、,Supports a healthy pregnancy Maternal DHA status母體DHA Increases DHA content of breast milk,Infants 82:125-32,Benefits of Supplemental Martek DHA during Lactation哺乳期 (200 mg/d), and improves in infant psychomotor development,Breast milk n=160,DHA as %TFA,4 mo postpartum,Score,P 0.0001,P = 0.008 afte

6、r Analysis of covariance,Higher scores on sustained attention in children at 5 yrs of age from mothers who supplemented with Martek DHA注意力集中,Leiter Test of sustained attention subtest,Jensen et al. Pediatric Res, 2004;55A,N = 141,P 0.008,DHA Supports Cardiovascular Health in Children and Adults DHA對

7、兒童和成人的心血管健康有益處,Favorable effects on blood lipid profile 對血脂結(jié)構(gòu)的益處 Reduced triglycerides (fasting and following a meal) 降低甘油三酸酯 Increased HDL (good cholesterol) 增加高密度脂蛋白 Improved LDL particle size 改善LDL微粒大小 Modest reductions in blood pressure (higher doses) 適度降低血壓(大劑量) Improved arterial compliance Ant

8、i-thrombotic effects Cardiac rhythm 心律 Stabilizes heart rhythm 穩(wěn)定心律 Lowers heart rate 減少心跳加速,FDA Qualified Health Claim Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. One serving of (name of food) provid

9、es (x) grams of EPA and DHA omega-3 fatty acids.”,DHA in Alzheimers and Dementia DHA同阿茲海默氏癥和癡呆癥,Calon 2004; Lim 2005 (Journal of Neuroscience) 科倫2004;利姆2005（神經(jīng)系統(tǒng)科學） Dietary DHA supplementation of transgenic Alzheimers mice:轉(zhuǎn)阿茲海默氏病毒的基因鼠攝入DHA補品： 70% reduction in insoluble plaque 70%降低不溶解性硬塊 25% reduct

10、ion in amyloid plaque burden 25%減少淀粉硬塊負擔 Improvement in learning and memory 提高學習能力和記憶力,Marteks DHA selected for NIH Clinical Trial 美國國家健康局首選馬泰克的DHA進行臨床試驗 DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimers Disease DHA（二十二碳六稀酸），一種歐米加 3 脂肪酸，顯示出減緩阿茲海默氏疾病惡化的作用 www

11、.,Calon et al. Neuron, 2004, 43:633-45. Lim et al. J Neurosci, 2005, 23:3032-40.,為什么選擇藻油DHA？,Fish Consumption Advisories During Pregnancy孕期食用魚類的注意事項,Women who may become pregnant, pregnant women, nursing mothers, and young children should: 將要懷孕、已懷孕、哺育期和喂養(yǎng)嬰幼兒的婦女應(yīng)該： Not eat fish cont

12、aining high levels of methyl mercury 不應(yīng)食用甲基汞含量高的魚類 Limit albacore tuna 限制長鰭金槍魚的食用量 Intake of fatty fish should not exceed the tolerable intake of environmental contaminants. 高脂魚的食用量不應(yīng)超過環(huán)境可忍受的捕撈污染度。 Dietary fish should be selected from a wide range of species without undue preference for large predat

13、ory fish such as swordfish and tuna which are more likely to be contaminated with methyl mercury 應(yīng)食多種類的魚，而不應(yīng)偏愛某種食肉魚如旗魚和金槍魚，這些魚很有可能含甲基汞。,European Expert Consensus Conference (PeriLip),/dms/admehg3.html,/PeriLipRecommendations.html,Fish and Fish Oil Risks are Highly Pub

14、licized,“Worlds supply of Fish in Peril” The Baltimore Sun, 11/03/06 “Mercury in Fish Brings Warning. Pregnant women, kids told of risks” Toronto Star, September 2006 “Mercury a lingering problem despite attempts at regulation” Chicago Tribune, June 2006 “Low Exposure to Organochlorides, Mercury Aff

15、ects Thyroid Status During Pregnancy” Environmental Health Perspectives, June 2006 “Report calls fish grave danger to public health” I, September 2006 “Whole Foods, Safeway, and Wild Oats to Post Seafood Mercury Warnings” , June 21, 2006 “Mercury in tuna: New safety concerns” Consumer Reports, July

16、2006 “Dont Touch the Tuna” Chicago Tribune, June 22, 2006 “Fish Oil May Pose Risk When Pregnant” The Sun Herald, May/June 2006 “Dioxins prompt second UK fish oil withdrawal” N, April 13, 2006 “Cancer fears over cod liver oil capsules” Daily Mail, March 15, 2006 “A New Tuna Warning for Pregnant Women

17、” Los Angeles Times, June 12, 2006 “Catching is Okay, But Eating is Risky” The Washington Post, June 1, 2006 “Avoid Canned Tuna If Pregnant” CBS News, June 6, 2006 “New Warnings on Mercury” Herald Tribune, June 27, 2006,Media Coverage Unlikely To Abate,Lifes DHA在保健品中的應(yīng)用,軟膠囊, 推介DHA對大腦和眼睛的效用 同時推介此產(chǎn)品是全

18、植物來源，不含魚油 香蕉和草莓口味 目標人群：3歲以上的兒童 DHA含量：125mg/serving,Spectrum 兒童可咀嚼的DHA軟膠囊,NuTru O-mega-Zen, 每粒膠囊含有300mg DHA 來自全天然植物,兩片裝膠囊,Deva - Omega-3 DHA supplement, 對成人的大腦，視力，心臟有益 產(chǎn)品定位純植物來源,營養(yǎng)棒,Single Layer Extruded,Single Layer Slabbed & Cut,Dual Layer Extruded,Dual,Layered Slabbed & Cut,Baked Bar,營養(yǎng)棒,每天一根45g的營

19、養(yǎng)棒含有正常孕期和哺乳期所必需的營養(yǎng)元素 - DHA，葉酸，蛋白質(zhì)，維生素A，維生素C，維生素E，維生素B12，維生素B6，鐵，鎂，鋅，鈣等,幼兒和孕婦食品,幼兒食品的出現(xiàn) 嬰幼兒奶粉公司的新產(chǎn)品延伸 主要瞄準1-3歲或3歲以上的兒童市場 強化DHA的市場認知度并且價位相對比較高端 進入原來傳統(tǒng)食品的市場 針對懷孕和哺乳期的婦女 在美國，超過48%針對懷孕的維生素市場（以銷售額計）添加了DHA 在兩年前只有15%-17%,營養(yǎng)混合物,Nutritional BlendsMeal replacement, weight-loss, body building, sports performanc

20、e, dietary supplement, soups, cereals, pastas, baking mixes, instant drink mixes, as well as other products., Promotes DHA for its brain, eye and heart health benefits Also promotes its vegetarian, non-fish status National Ad promoting that its vegetarian, contaminant free, and has no fishy Taste pa

21、ckage:500ml,Flora - Udos Choice DHA Oil Blend,Food & Beverage Products Containing Marteks lifesDHA,WhiteWave Foods Silk Plus Omega-3 DHA soy milk (U.S.) General Mills Yoplait Kids (U.S.) Latteria Meranos MenteViva (drinkable yogurt) (Italy) Parmalat Australias Vaalia My First Yoghurt (Australia),Ome

22、ga-3 Awareness is Growing,% of General Population Aware of the Terms Omega-3 and DHA,Source: Multisponsor surveys, U.S. population. Data is representative of global awareness trends.,DHA的認知度 不斷上升中,Contaminants in Fish Oil are a Real Risk,Quality Control 質(zhì)量控制問題 An independent study* of 24 commerciall

23、y available fish oil supplements revealed that all contained measurable levels of PCBs 一個中立的研究揭示* ：24種市場上的魚油補品都含數(shù)量不等的可測量的多氯聯(lián)苯。 2 supplements with Marteks oil were also tested and no PCBs were detected 其中含馬泰克藻油的兩種補品也被測驗 沒有發(fā)現(xiàn)多氯聯(lián)苯。 Boots plc withdraws fish oil supplements from the market due to excessive dioxin levels (April, 2006) 英國博姿公司由于其市場上魚油補品的二惡英含量太高， 撤回其產(chǎn)品（2006年4月）。 Batches of cod liver oil tablets are withdrawn from the market due to excessive dioxin levels (March, 2006) 大批鱈魚魚肝油藥片由于含過量二惡英從市場撤回（2006年3月）。,* Source: Journal of Food Science, Vol. 68, N