QYHJFormula basedIntegratedHerbsandWesternmedicineTherapyinElderlyPatientswithPancreaticCancer LumingLiuDepartmentofIntegrativeOncologyFudanUniversityCancerHospitalShanghaiChina Stagedistributionatdiagnosisand5 yearrelativesurvivalrateamongpatientswithpancreaticcancerUS 1996 2003 5 yearrelativesurvivalrate Stagedistributionatdiagnosis FromJemal A etal CACancerJClin2008 58 71 96 The4thleadingcauseofcancer relatedmortalityinU S A EdwardsBKetal Annualreporttothenationonthestatusofcancer 1973 1999 featuringimplicationsofageandagingonU S cancerburden Cancer 2002 41 pancreaticcanceroccursover75yearsold 71 pancreaticcanceroccursover65yearsold StandardizedIncidenceofcancerinShanghaiCity Incidenceofpancreaticcancerfrom1972 1999increased72 2 inmaleand56 2 infemale 2 orsoincreaseeveryyear ArapidlyincreasingtrendintheincidenceforPC the8thand9thformenandwomeninShanghai LIUJusi etal Tumor2004 24 1 11 15 ca CharacteristicsinElderlyPatientswithCancers Ageingandsickly Cancerprogressionrelativelyslow Cancermetastasisprobablyless Multipleprimarycarcinomaincreasing PoortolerancetoChem RT becauseofitslosingphysiologicalfunctioninelderlypatients AretrospectivestudyonadvancedpancreaticcancertreatedbyTCMHerbs Ananalysisof56casesLiuLM WuLC LinSY etal TherapeuticEvaluationonAdvancedPancreaticCancerTreatedbyIntegrativeChineseandWesternMedicine ClinicalAnalysisof56Cases ChinJIntegrativeMed 2003 9 1 39 43 56caseswithadvancedpancreaticcancertreatedbychemotherapyaloneorchemotherapycombinedwithTCMdecoctionTheTCM CHEMOgrouphadabettersurvivalovertheCHEMOgroup P 0 04 TherewasasuperiorityofchemotherapycombinedwithTCMtochemotherapyinobjectiveresponse p 0 049 andinimprovementofsymptoms P 0 002 Case167y F Symptomsbeforeoperation Jaundice upperabdominalpain Tumorsize 8 9cmOperationtime Oct 8 1997 Tumorunresected 1999 FENGErbaoNov20047 yearbirthday Followupinxinhua 新華 HospitalHangzhouinMarch18 2006 1 1 1 232casesfromMay1 2002 Dec 31 2005werereviewed and134caseswithadvancedpancreaticcancerhadpathologicaldiagnosiswereincludedinthisanalysis 94nopriortreatment 40hadtreatment Weexcluded98cases nopathology64 not provenbypathology16 neuroendocrinecarcinoma2 nomassafterpancreaticoperation7 clinicaldataincomplete4 herbstreatment 1month5 stageII10例 stageIII15 stageIV109withremoteM ARetrospectiveStudyonAdvancedPancreaticCancerTreatedwithIntegratedWesternMedicineandTraditionalChineseherbs Analysisof134Cases2002 2005ShenYe hua LiuLu ming MengZhi qiang ChenZhen LinJun hua ZhouZhen hua ChenHao WangKun FuJie YuEr xinDepartmentofIntegratedOncology FudanUniversityCancerHospital Survival MedianSurvival5 7monsHalfyrsurvival47 0 1 yrsurvival17 5 2 yrsurvival8 7 3 yrsurvival7 2 QYHJHerbsP 0 001 mons QYHJHerbs OthersHerbs 2006 2004 2005 2007 2008 Case2 BeforeTreatment2002 7 25 AfterTreatment2003 6 6 Case3Xingxx 18 07 2002Admission 2010 1 1 Follow up Case3 2011 Case4WuJianpingxx F 44yrs JiangsunativeDiagnoseddata May2003CT PCMass10cm twoloberlivermultimasses biggestoneis9cm Case4 Liverbiopsy metastasispoordifferentiatedadenocarcinoma Treatment May28 2003 Gemcitabine 1 4g m2 Oxalipatin 150mg m2 THP60mg Lipiodol13mlin1stcycleTAIforlivermetastasis June25 2003 July23 20033DCRT6MVX ray3160cGy 20FxforPC Aug11 2003 Gemcitabine1 4g Oxalipatin200mg THP60mg LP10mlin2ndcycleTAI Herbstreatment July31 2003 7 31Aftertreatment intrahepaticmetastasismassesregression andmassnotclear May22 2003BeforeTreatment May2003PCMassBeforetreatment Oct 2003PCmassnotclear July2003aftertreatmentPCmassregression Case5Yangxxlongsurvivalwithcancer before 13 10 2004 after 17 04 2008 F 43y ShanghainativeDiagnoseddata 31 08 2004Diagnosis PancreaticCawithLM 09 2004 bothlungM 09 2004 post peritoneumLNm 09 2004 multi bone 11 2006 Cytology denocarcinomaFollow up 31 12 2009Survives86mons Case5 MultimodalityTreatmentofPancreaticCancerWithLiverMetastasesUsingChemotherapy RadiationTherapy and orChineseHerbalMedicine Analysisof164Cases HuaqiangOuyang PengWang MD ZhiqiangMeng MD ZhenChen Er xinYu HuanJin DavidZ Chang ZhongxingLiao LorenzoCohen PhD andLumingLiu Pancreas 2011 40 1 120 126 IF 2 607 RESULTS From2002to2007 164casesofpancreaticcancerpatientswithlivermetastasisdiagnosedbypathologyQYHJFormulaisindependentprognosticfactors QingyihuajiFormula QYHJ Liuetal ChinJIntegrMed 2005Shenetal TraditChinMed 2006Shenetal CJBMTCM 2006Shenetal ChinaOncology 2006 Clinical experimentalstudyshowedthat QYHJisoftheeffectsonanti pancreaticcancer AprospectiverandomizedcontrolledPhaseIIclinicaltrialIntegrativetherapyofQYHJ Gemcitabine basedchemotherapyorwith3DCRTforadvancedpancreaticcancerShenYehua LiuLuming ChenZhen MengZhiqiang LinJunhua ZhouZhenhua ChengWenwu YuErxin JiangGuoliang IntegrativeMedicineProgramofLiver GallbladderandPancreaticCancer FudanUniversityCancerHospital JournalofTraditionalChineseMedicine2010 51 12 1093 1097 StudyDesign PrimaryObjective Response MedianSurvival OverallSurvivalSecondaryobjective ClinicalBenefits AdverseEffects R GEMd1 3DCRTd15 QYHJherbsfor4mons GEMd1 3DCRTd15 Placebofor4mons TAI Gem1 0g m2 Oxaplatin135mg m2orCisplatin40mg m23DCRT 6MVXray 36 40Gy 1 8 2Gy AdvancedPC Researchsubjects participants 83caseswereenrolledintothisstudyduringMarch 2004 2009 1pathologicdiagnosischanged 2notreatment 1 QYHJ obstructivejaundice 1 Control bowelobstruction 80receivedtreatmentandincludedinthestudy QYHJ41cases control39 ComparisonofControlandQYHJGroup ComparisonofControlandQYHJGroup Response Of80 72isvaluableassesment 5casesarePRinQYHJgroup noCRorPRincontrol Survival Lastestfollow up nolostonDec 1 2009 3cases allinQYHJ stillsurvive P 0 046 GroupControlQYHJ AdverseEffects P 0 05 GIbleeding Vomit Norsea 3 4 Thrompenia 3 4 Leucopenia ALP AKP Control Prognosticanalysisof190elderlypatientswithPancreaticcancertreatedbyintegratedHerbsandWesternmedicinePanY LiuLM ChenZ MengZQ LinJH ChenH WangK ShenYH ZhuXYChineseJ ClinHepatol 2014 30 4 330 333 190elderlypancreaticcancerpatientstreatedbyintegratedHerbsandWesternmedicineduringJan 2002 Dec 2008 Provedbyhistopathology63 cytology127 Female 126 male 64 averageage 67 93 5 54 60 83ys UICCstage 52 27 4 stage 138 72 6 distantmetastasis132 69 5 survivaltimeofQYHJformulatoTNM IIIPancreaticcancerinelderlypatientswithnon surgery survivaltimeofQYHJformulatoTNM IVPancreaticcancerinelderlypatientswithnon surgery Conclusion Forelderlypatientswithadvancepancreaticcancer itisbesttochooseQYHJ basedformulawithoutothers F 41y Anhui和縣native Diagnosisdata 01 04 2005 Diagnosis PancCa CT 02 2005 withlivermetastasis liverboispy 04 2005 Cytology Adenocarcinoma 6 Case6 Treatment21 02 2005CT CancerinpancreatictailwithliverM 11 03 2005CT Cancerinpancreatictailwithlivermulti M 04 04 2005Liverboipsy Adenocarcinoma 05 04 20051thliverTACE 28 04 2005PCERT QYHJ 03 08 2005MRI Nomassinpancreas livermulti M 10 08 20052thliverTACE 14 11 20063thTACE 07 07 2007CT PRinlivermulti M 31 12 2009Survives59mons MRI MRaftertreatment Before AfterTreatment Case7Chenxx M 62y Helongjiang大慶native Diagnosisdata 21 03 2003Diagnosis Pancreaticcancerresected 09 1999 Pathology AdenocarcinomawithliverMLiverbiopsy 12 2002 metastaticpoordifferentiatedAdenocarcinomaStomachCaresected 09 1999 Pathology Adenocarcinoma Treatment 09 1999 Pancreaticcancerresected12 31 2009 Survives6 yearmore 2003 4 15 Case8Lin M 53y Zhejiang瑞安RuiAnnativeDiagnosisdata 21 03 2005Diagnosis PancCa CT 03 2005 withlivermetastasis liverboispy 05 2005 Cytology Liverbiopsy 28 03 2005 poordifferentiatedcarcinoma longsurvivalwithcancer March 2005 now Dec 30 2009 Survives58mons Treatment31 03 20051thliverTACE19 07 20053thliverTACE 28 07 2005HIFUforpancreaticmass 12 06 200811thliverTACE 8 Case10Zhangxx F 51y ShanghaiNative1stDiag