1、 HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html ADC HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html CytotoxinADC PayloadADC cytotoxins (also known as payloads) are cytotoxic agents that induce target cell death in Antibody D

2、rug Conjugates (ADCs). AnADC is a targeted agent composed with a monoclonal antibody, a linker and a cytotoxin. The cytotoxin is the most importantcomponent as it determines the potency to kill cancer cells of an ADC.There are many cytotoxins which are currently being used such as Calicheamicins, Du

3、ocarmycins, Pyrrolobenzodiazepines (PBDs),Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on theirmechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNAminor grove bi

4、nders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damagingagents. Auristatins and Maytansinoids are tubulin inhibitors. Except for the listed cytotoxins, there are numbers of traditionalcytotoxic agents with similar mechanisms of killing cancer cells and

5、 can also be used in the development of ADCs.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html ADC HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html HYPERLINK https:/www.MedChemE/Targets/ADC Cytotoxin.html Cytotoxin HYPERLINK https:/www.MedChemE/cbi-cdpi1.html (+)-CBI-CD

6、PI1 HYPERLINK https:/www.MedChemE/cbi-cdpi1.html HYPERLINK https:/www.MedChemE/cbi-cdpi2.html (+)-CBI-CDPI2Cat. No.: HY-128880 Cat. No.: HY-128881(+)-CBI-CDPI1 is an enhanced functional analog ofCC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent.(+)-CBI-CDPI1 is an antibody drug conjugates(ADCs) toxin

7、.(+)-CBI-CDPI2 is an enhanced functional analog ofCC-1065. (+)-CBI-CDPI1 is a DNA alkylating agent.(+)-CBI-CDPI2 is an antibody drug conjugates(ADCs) toxin.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK htt

8、ps:/www.MedChemE/s-seco-duocarmycin-sa.html (S)-Seco-Duocarmycin HYPERLINK https:/www.MedChemE/s-seco-duocarmycin-sa.html HYPERLINK https:/www.MedChemE/s-seco-duocarmycin-sa.html SACat. No.: HY-129356A HYPERLINK https:/www.MedChemE/10-deacetyl-7-xylosyl-paclitaxel.html 10-Deacetyl-7-xylosyl HYPERLIN

9、K https:/www.MedChemE/10-deacetyl-7-xylosyl-paclitaxel.html HYPERLINK https:/www.MedChemE/10-deacetyl-7-xylosyl-paclitaxel.html paclitaxel HYPERLINK https:/www.MedChemE/10-deacetyl-7-xylosyl-paclitaxel.html (10-Deacetyl-7-xylosyltaxol;10-Deacetylpaclitaxel 7-Xyloside; ) Cat. No.: HY-20584(S)-Seco-Du

10、ocarmycin SA is a DNA alkylator,cytotoxic to cancer cells, and acts as a ADCcytotoxin for antibody-drug conjugates.10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel(a microtubule stabilizing agent; enhances tubulinpolymerization) derivative with improvedpharmacological features.Purity: 99.0%Clinical

11、Data: No Development ReportedSize: 5 mgPurity: 98.19%Clinical Data: No Development ReportedSize: 10 mg, 50 mg HYPERLINK https:/www.MedChemE/17-aep-ga.html 17-AEP-GA HYPERLINK https:/www.MedChemE/17-aep-ga.html HYPERLINK https:/www.MedChemE/17-gmb-apa-ga.html 17-GMB-APA-GACat. No.: HY-133570 Cat. No.

12、: HY-13099717-AEP-GA, an HSP90 antagonist, is a potentinhibitor of glioblastoma cell proliferation,survival, migration and invasion. ADCs Toxin.17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GAis a potent HSP90 inhibitor and used for latentT. gondii infection research.Purity: 98%Clinical Data: No Dev

13、elopment ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/2-3-cgamp-c2-sh.html 2,3-cGAMP-C2-SH HYPERLINK https:/www.MedChemE/2-3-cgamp-c2-sh.html HYPERLINK https:/www.MedChemE/7-aminomethyl-10-methyl-11-fluoro-camptothecin.html 7

14、-Aminomethyl-10-methyl-11-fluoro HYPERLINK https:/www.MedChemE/7-aminomethyl-10-methyl-11-fluoro-camptothecin.html HYPERLINK https:/www.MedChemE/7-aminomethyl-10-methyl-11-fluoro-camptothecin.html camptothecinCat. No.: HY-141663 Cat. No.: HY-1321602,3-cGAMP-C2-SH is a ADC cytotoxin that isextracted

15、from patent US20210015941, example 24.7-Aminomethyl-10-methyl-11-fluoro camptothecin isa cytotoxin ofMC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin(HY-132158compound 21a).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development Rep

16、ortedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/7-mad-mdcpt.html 7-MAD-MDCPT HYPERLINK https:/www.MedChemE/7-mad-mdcpt.html HYPERLINK https:/www.MedChemE/aeruginosin-865.html Aeruginosin HYPERLINK https:/www.MedChemE/aeruginosin-865.html HYPERLINK https:/www.MedChemE/aeruginosin-865.html 865Cat.

17、 No.: HY-132162 Cat. No.: HY-1309947-MAD-MDCPT, a Camptothecin analog, is a toxinpayload in antibody drug conjugates (ADCs).Aeruginosin 865, isolated from terrestrialcyanobacterium Nostoc sp. Lukeov 30/93, is thefirst aeruginosin-type peptide containing both afatty acid and a carbohydrate moiety. Ae

18、ruginosin865 inhibits translocation of NF-kB to thenucleus.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/agrochelin.htm

19、l AgrochelinCat. No.: HY-130995 HYPERLINK https:/www.MedChemE/INNO-206.html Aldoxorubicin(INNO-206; DOXO-EMCH) Cat. No.: HY-16261Agrochelin, an alkaloid cytotoxic antibiotic, isproduced by the fermentation of a marineAgrobacterium sp. Agrochelin has cytotoxicactivity in tumor cell lines.Aldoxorubici

20、n (INNO-206) is an albumin-bindingprodrug of Doxorubicin (DNA topoisomerase IIinhibitor), which is released from albumin underacidic conditions. Aldoxorubicin (INNO-206) haspotent antitumor activities in various cancer celllines and in murine tumor models.Purity: 98%Clinical Data: No Development Rep

21、ortedSize: 5 mg, 10 mg, 25 mgPurity: 95.99%Clinical Data: Phase 3Size: 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/aminohexylgeldanamycin.html Aminohexylgeldanamycin(AHGDM) Cat. No.: HY-133571 HYPERLINK https:/www.MedChemE/aminohexylgeldanamycin-hydrochloride.html Aminohexylgeldanamycin

22、 HYPERLINK https:/www.MedChemE/aminohexylgeldanamycin-hydrochloride.html HYPERLINK https:/www.MedChemE/aminohexylgeldanamycin-hydrochloride.html hydrochloride(AHGDM hydrochloride) Cat. No.: HY-133571AAminohexylgeldanamycin (AHGDM), a Geldanamycinderivative, is a potent HSP90 inhibitor.Aminohexylgeld

23、anamycin shows antiangiogenic andantitumor activities.Aminohexylgeldanamycin (AHGDM) hydrochloride, aGeldanamycin derivative, is a potent HSP90inhibitor. Aminohexylgeldanamycin hydrochlorideshows antiangiogenic and antitumor activities.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10

24、mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/aniline-mpb-amino-c3-pbd.html Aniline-MPB-amino-C3-PBDCat. No.: HY-135900 HYPERLINK https:/www.MedChemE/Ansamitocin-P-3_acute_.html Ansamitocin HYPERLINK https:/www.MedChemE/Ansamitocin-P-3_acute

25、_.html HYPERLINK https:/www.MedChemE/Ansamitocin-P-3_acute_.html P HYPERLINK https:/www.MedChemE/Ansamitocin-P-3_acute_.html HYPERLINK https:/www.MedChemE/Ansamitocin-P-3_acute_.html 3(Antibiotic C 15003P3; Maytansinol butyrate) Cat. No.: HY-19839Aniline-MPB-amino-C3-PBD is a cytotoxic agentcomprise

26、d non-alkylating group.Aniline-MPB-amino-C3-PBD is a sequence-selectiveDNA minor-groove binding agent.Aniline-MPB-amino-C3-PBD acts as the payload forADCs. Antimicrobial activity.Ansamitocin P 3 exhibits antitumour activity, isan antibody drug conjugate cytotoxin. The moreinformation please refer to

27、 Ansamitocin P-3(HY-15739, a tubulin inhibitor).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Ansamitocin-P-3.html Ansamitocin HYPERLINK https:/

28、www.MedChemE/Ansamitocin-P-3.html HYPERLINK https:/www.MedChemE/Ansamitocin-P-3.html P-3 HYPERLINK https:/www.MedChemE/Ansamitocin-P-3.html HYPERLINK https:/www.MedChemE/Auristatin-E.html Auristatin HYPERLINK https:/www.MedChemE/Auristatin-E.html HYPERLINK https:/www.MedChemE/Auristatin-E.html E(Ant

29、ibiotic C 15003P3; Maytansinol isobutyrate) Cat. No.: HY-15739Cat. No.: HY-15582Ansamitocin P-3 (Antibiotic C 15003P3) is amicrotubule inhibitor. Ansamitocin P-3 is amacrocyclic antitumor antibiotic.Auristatin E is a cytotoxic tubulin modifier withpotent and selective antitumor activity; MMAEanalog

30、and cytotoxin in Antibody-drug conjugates.Auristatin E inhibits cell division by blockingthe polymerisation of tubulin.Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.36%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 50 mg, 10

31、0 mg HYPERLINK https:/www.MedChemE/Auristatin-F.html Auristatin HYPERLINK https:/www.MedChemE/Auristatin-F.html HYPERLINK https:/www.MedChemE/Auristatin-F.html F HYPERLINK https:/www.MedChemE/Auristatin-F.html HYPERLINK https:/www.MedChemE/azonafide-peaba.html Azonafide-PEABACat. No.: HY-15583 Cat.

32、No.: HY-126664Auristatin F is a potent cytotoxin. Auristatin F, apotent microtubule inhibitor and vasculardamaging agent (VDA), can be used in antibody-drugconjugates (ADC).Azonafide-PEABA is a cytotoxic drug moiety.Purity: 99.11%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 9

33、8%Clinical Data: No Development ReportedSize: 1 mg, 5 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/c-11.html C-11Cat. No.: HY-100861 HYPERLINK https:/www.MedChemE/Calicheamicin.html Calicheamicin(Calicheamicin 1) Cat. No.: HY-19609C-11 is a tubulin inhibitor and acts as an ADCcytotoxin, displays c

34、ytotoxicity for carcinoma celllines.Calicheamicin, an antitumor antibiotic, is acytotoxic agent that causes double-strand DNAbreaks. Calicheamicin is a DNA synthesisinhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.28%Clinical Data: No Development ReportedSize: 1

35、mg, 5 mg HYPERLINK https:/www.MedChemE/Campathecin.html Camptothecin(Campathecin; (S)-(+)-Camptothecin; CPT) Cat. No.: HY-16560 HYPERLINK https:/www.MedChemE/camptothecin-d5.html Camptothecin-d5(Campathecin-d5; (S)-(+)-Camptothecin-d5; CPT-d5) Cat. No.: HY-16560SCamptothecin (CPT), a kind of alkaloi

36、d, is a DNAtopoisomerase I (Topo I) inhibitor with an IC of50679 nM.Camptothecin-d5 (Campathecin-d5) is the deuteriumlabeled Camptothecin. Camptothecin (CPT), a kindof alkaloid, is a DNA topoisomerase I (Topo I)inhibitor with an IC of 679 nM.50Purity: 99.69%Clinical Data: LaunchedSize: 10 mM 1 mL, 1

37、00 mg, 500 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/cc-885-ch2-peg1-nh-ch3.html CC-885-CH2-PEG1-NH-CH3 HYPERLINK https:/www.MedChemE/cc-885-ch2-peg1-nh-ch3.html HYPERLINK https:/www.MedChemE/corixetan.html CorixetanCat. No.: HY-145449 Cat. No.

38、: HY-132851CC-885-CH2-PEG1-NH-CH3 is a neoDegrader that canbe used in the synthesis of Antibody neoDegraderConjugate (AnDC).Corixetan is a highly efficient thorium chelator.Corixetan can efficiently complex Th-227 withsufficient in vivo stability.Purity: 98%Clinical Data: No Development ReportedSize

39、: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/D8-MMAF.html D8-MMAF HYPERLINK https:/www.MedChemE/D8-MMAF.html HYPERLINK https:/www.MedChemE/daun02.html Daun02(Monomethylauristatin F D8) Cat. No.: HY-15579SCat. No.: HY-13061D8-MMAF hydroch

40、loride is a deuterated form of MMAFhydrochloride. MMAF Hydrochloride, a potenttubulin polymerization inhibitor, is used as aantitumor agent and a cytotoxic component ofantibody-drug conjugates (ADCs).Daun02 is a prodrug of the topoisomeraseinhibitor Daunorubicin.Purity: 98%Clinical Data: No Developm

41、ent ReportedSize: 1 mg, 5 mgPurity: 98.85%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 2 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/daunorubicin.html Daunorubicin HYPERLINK https:/www.MedChemE/daunorubicin.html HYPERLINK https:/www.MedChemE/Daunorubicin-Hydrochloride.html Daunorubicin

42、HYPERLINK https:/www.MedChemE/Daunorubicin-Hydrochloride.html HYPERLINK https:/www.MedChemE/Daunorubicin-Hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/Daunorubicin-Hydrochloride.html (Daunomycin hydrochloride; RP(Daunomycin; RP 13057; Rubidomycin) Cat. No.: HY-13062A 13057 hydrochlo

43、ride; Rubidomycin hydrochloride) Cat. No.: HY-13062Daunorubicin (Daunomycin; RP 13057; Rubidomycin)is a topoisomerase II inhibitor with potentantineoplastic activities. Daunorubicin(Daunomycin; RP 13057; Rubidomycin) inhibits DNAand RNA synthesis in sensitive and resistantEhrlich ascites tumor cells

44、.Daunorubicin (Daunomycin) hydrochloride is atopoisomerase II inhibitor with potentantineoplastic activities. Daunorubicinhydrochloride inhibits DNA and RNA synthesis insensitive and resistant Ehrlich ascites tumorcells.Purity: 98%Clinical Data: LaunchedSize: 5 mg, 10 mg, 25 mgPurity: 99.23%Clinical

45、 Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/dc0-nh2.html DC0-NH2 HYPERLINK https:/www.MedChemE/dc0-nh2.html HYPERLINK https:/www.MedChemE/DC1.html DC1Cat. No.: HY-129379 Cat. No.: HY-112

46、899DC0-NH2 is an effector moiety for ADC and asimplified analog of DC1 with better stability.DC0-NH2 is about 1000-fold more cytotoxic thancommonly used anticancer drugs (ex. Doxorubicin).DC1, an analogue of the minor groove-binding DNAalkylator CC-1065, is a ADC Cytotoxin. DC1 can beused in synthes

47、is of antibody-drug conjugates forthe targeted treatment of cancer.Purity: 95.21%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: Phase 2Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/dc10sme.html DC10SMe HYPERLINK https:/www.MedChemE/dc10sme.html HY

48、PERLINK https:/www.MedChemE/DC1-SMe.html DC1SMeCat. No.: HY-135122 Cat. No.: HY-112898DC10SMe is a DNA alkylator, can be used in thesynthesis of Antibody-drug Conjugate (ADC).DC10SMe exhibits IC s of 15 pM, 12 pM, and 12 pM50for Ramos, Namalwa, and HL60/s cancer cells,respectively.DC1Sme, a DC1 deri

49、vative, exhibits IC values of5022 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa,HL60/s and COLO 205 cancer cells, respectively.DC1, an analogue of the minor groove-binding DNAalkylator CC-1065, is a ADC Cytotoxin.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clinical

50、 Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/dc4.html DC4 HYPERLINK https:/www.MedChemE/dc4.html HYPERLINK https:/www.MedChemE/dc41.html DC41Cat. No.: HY-135125 Cat. No.: HY-112901DC4, an ADC cytotoxin, can be used in thesynthesis of

51、 Antibody-drug Conjugate (ADC). DC4can be used for the targeted treatment of cancer.DC41 is a DC1 derivative. DC1, a simplifiedanalogue of CC-1065, is an antibody conjugate ofcytotoxic DNA alkylators for the targetedtreatment of cancer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 m

52、gPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/dc41-sme.html DC41SMe HYPERLINK https:/www.MedChemE/dc41-sme.html HYPERLINK https:/www.MedChemE/dc44sme.html DC44SMeCat. No.: HY-112900 Cat. No.: HY-135124DC41SMe, a DC1 derivative, shows cytotoxicity in

53、Ramos, Namalwa, and HL60/s cells with IC s50ranging from 18-25 pM. DC1, a simplified analogueof CC-1065, is an antibody conjugate of cytotoxicDNA alkylators for the targeted treatment ofcancer.DC44SMe, a phosphate prodrug of cytotoxic DNAalkylator DC44, can be used in the synthesis ofAntibody-drug C

54、onjugate (ADC). DC44SMe exhibitsIC s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos,50Namalwa, and HL60/s cancer cells, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/dc4sme.html D

55、C4SMe HYPERLINK https:/www.MedChemE/dc4sme.html HYPERLINK https:/www.MedChemE/diacetyl-agrochelin.html Diacetyl HYPERLINK https:/www.MedChemE/diacetyl-agrochelin.html HYPERLINK https:/www.MedChemE/diacetyl-agrochelin.html AgrochelinCat. No.: HY-135123 Cat. No.: HY-130996DC4SMe, a phosphate prodrug o

56、f cytotoxic DNAalkylator DC4, can be used in the synthesis ofAntibody-drug Conjugate (ADC). DC4SMe exhibitsIC s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos,50Namalwa, and HL60/s cancer cells, respectively.Diacetyl Agrochelin is an acetyl derivative ofAgrochelin, which is produced by the fermentationof a

57、 marine Agrobacterium sp. DiacetylAgrochelin has cytotoxic activity in tumor celllines.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgwww.MedChemE 5 HYPERLINK https:/www.MedChemE/dimethyl-sgd-1882.html Dimethy

58、l-SGD-1882(Dimethyl-PBD dimer) Cat. No.: HY-126678 HYPERLINK https:/www.MedChemE/dm1-sme.html DM1-SMeCat. No.: HY-100128Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highlypotent DNA alkylator, and is used as anantibody-drug conjugate (ADC) cytotoxin. PBD Dimeris a DNA alkylator which inhibits DNA rep

59、lication.DM1-SMe is an unconjugated form of theMaytansinoid in IMGN901. DM1-SMe is about3-10-fold more potent than the parent drugMaytansine, with IC s ranging from 0.003 to 0.0150nM for DM1-SMe in a panel of human tumor celllines.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPuri

60、ty: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/dm3.html DM3(Maytansinoid DM3) Cat. No.: HY-130080 HYPERLINK https:/www.MedChemE/dm3-sme.html DM3-SMeCat. No.: HY-130081DM3 (Maytansinoid DM3) is a maytansine analogbearing disulfide or thiol groups and a tub