1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPNU-282987Cat. No.: HY-12560ACAS No.: 123464-89-1分式: CHClNO分量: 301.21作靶點(diǎn): nAChR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 61 mg

2、/mL (202.52 mM)H2O : 50 mg/mL (166.00 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3199 mL 16.5997 mL 33.1994 mL5 mM 0.6640 mL 3.3199 mL 6.6399 mL10 mM 0.3320 mL 1.6600 mL 3.3199 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) PN

3、U-282987 is dissolved in saline5.BIOLOGICAL ACTIVITY物活性 PNU-282987是_alpha_7 nAChR受體選擇性激動(dòng)劑，Ki值為26nM，對(duì)_alpha_1_beta_1_gamma_delta_和_alpha_3_beta_4nAChRs親和弱。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Biomed Res. 2017; Special Issue: ISSN 0970. Biomed Res-India. 2019 Apr.See more custo

4、mer validations on HYPERLINK / www.MedChemEREFERENCES1. Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholinereceptors. J Med Chem. 2005 Feb 24;48(4):905-8.2. Li F, et al. The protective effect of PNU-282987, a select

5、ive 7 nicotinic acetylcholine receptor agonist, on the hepatic ischemia-reperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor B activation in mice.Shock. 2013 Feb;39(2):197-203.3. Stuckenholz V, et al. The 7 nAChR agonist PNU-282987 r

6、educes inflammation and MPTP-induced nigral dopaminergic cell loss inmice. J Parkinsons Dis. 2013;3(2):161-72.4. Mesa-Gresa P, et al. Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987.Behav Processes. 2014 Mar;103:117-24.5. Dong Jun Yu, et al. Effect of ischemic preconditioning combined with 7 nAchR agonists on limb ischemia-reperfusion lung injury in rat.Biomed Res. 2017; Special Issue: ISSN 0970.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only