1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEEbastineCat. No.: HY-B0674CAS No.: 90729-43-4Synonyms: LAS-W 090; RP64305分式: CHNO分量: 469.66作靶點: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6

2、 months-20C 1 month溶解性數(shù)據(jù)體外實驗 Ethanol : 58.75 mg/mL (125.09 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.1292 mL 10.6460 mL 21.2920 mL5 mM 0.4258 mL 2.1292 mL 4.2584 mL10 mM 0.2129 mL 1.0646 mL 2.1292 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Eba

3、stine(LAS-W 090;RP64305)是長效的H1組胺受體拮抗劑。REFERENCES1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE1. Tagawa, M., et al., Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): acomparative study of ebastine, a second-generation antihistamine, and (+)-chl

4、orpheniramine, a classical antihistamine. Br J Clin Pharmacol,2001. 52(5): p. 501-9.2. Bousquet, J., et al., A 12-week, placebo-controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in thetreatment of perennial allergic rhinitis. Multicentre Study Group. Allergy, 1999. 54(6): p. 562-8.3. Sastre, J., Ebastine in allergic rhinitis and chronic idiopathic urticaria. Allergy, 2008. 63 Suppl 89: p. 1-20.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>