1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOzenoxacinCat. No.: HY-14957CAS No.: 245765-41-7Synonyms: T-3912分式: CHNO分量: 363.41作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 6 mg/mL (16.51 mM; Need ul

2、trasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.7517 mL 13.7586 mL 27.5171 mL5 mM 0.5503 mL 2.7517 mL 5.5034 mL10 mM 0.2752 mL 1.3759 mL 2.7517 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Ozenoxacin種氟喹諾酮抗 劑，能夠抵抗多數(shù)從在膚和軟組織感染中分離的微物。IC50 & Target Bacter

3、ial 1體外研究Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positivemicroorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEof MRSA, MSSA, MSSE, and MRSE with 2, 3,

4、or 4 mutations in the gyrA and grlA (parC) genes 1.Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of 1010 and 5.3 1010, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin 2.REFERENCES1. Lpez Y, et al. In vitro activity of Ozenoxa

5、cin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. AntimicrobAgents Chemother. 2013 Dec;57(12):6389-92.2. Lpez Y, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci.J Antimicrob Chemother. 2015 Jan;70(1):57-61McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02