1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEU18666ACat. No.: HY-107433CAS No.: 3039-71-2分式: CHClNO分量: 424.06作靶點(diǎn): Others作通路: Others儲存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (117.91 mM; Need ultrasonic)H2O : 10 mg/mL (23.58 mM; Ne

2、ed ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.3582 mL 11.7908 mL 23.5816 mL5 mM 0.4716 mL 2.3582 mL 4.7163 mL10 mM 0.2358 mL 1.1791 mL 2.3582 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請根據(jù)您的實(shí)驗(yàn)動物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)

3、儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (5.90 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (5.90 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (5.90 m

4、M); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 U18666A，個細(xì)胞滲透性藥物，是膽固醇合成和轉(zhuǎn)運(yùn)的抑制劑。IC50 & Target Cholesterol 1 2.體外研究 U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes

5、and suppresse de novo sterol biosynthesis in treated infected cells. It isalso observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggestingdengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication 1 2.REFERENCES1

6、. Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012Jan;93(1):191-8.2. Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerouspathophysiological processes. Lipids. 2009 Jun;44(6):477-87.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: